A5029113547- Aortic aneurysm repair treatments
- Liver Disease and Transplantation
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
- Uterine Myomas and Treatments
- Optical Coherence Tomography Applications
- Cancer-related molecular mechanisms research
- Salmonella and Campylobacter epidemiology
- Renal and Vascular Pathologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Optical Imaging and Spectroscopy Techniques
- Vasculitis and related conditions
- Biomarkers in Disease Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Birth, Development, and Health
- Inflammasome and immune disorders
- Infectious Aortic and Vascular Conditions
- Ferroptosis and cancer prognosis
Medical University of Vienna
2016-2025
Vienna General Hospital
2022
University of Vienna
2021
Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, cardiovascular outcomes.
Nonpathogenic torque teno viruses (TTVs) are highly prevalent in transplant recipients and associated with immunosuppression. Studies kidney patients have proposed assessment of TTV load for risk stratification clinically overt graft rejection. The value quantification the context subclinical rejection has not been evaluated.In this prospective trial, 307 consecutive were subjected to per-protocol monitoring plasma TTV. was analyzed protocol biopsies (n = 82), scheduled 1 year...
Arterial hypertension (HTN) and type 2 diabetes (T2DM) are contributors to chronic kidney disease leading glomerulomegaly podocyte loss. Enlarged glomeruli depletion associated with progression. This retrospective study aimed investigate morphometric changes in patients HTN the contribution of coexisting T2DM HTN. Glomerular structure was estimated stereologically unaffected areas tumor nephrectomies 99 patients. Morphometric features between subjects (n=47), HTN+T2DM (n=32), controls...
Background: There is an urgent need to better understand the mechanisms underlying acute and long-term neurological symptoms after COVID-19. Neuropathological studies can contribute a understanding of some these mechanisms. Methods: We conducted detailed postmortem neuropathological analysis 32 patients who died due COVID-19 during 2020 2021 in Austria. Results: All cases showed diffuse white matter damage with microglial activation variable severity, including one case hemorrhagic...
Background Biomarkers for response prediction to anti-programmed cell death 1 (PD-1) immune checkpoint inhibitors (ICI) in patients with head and neck squamous carcinoma (HNSCC) are urgently needed a personalized therapy approach. We investigated the predictive potential of inflammatory parameters DNA methylation profiling HNSCC treated anti-PD-1 ICI. Methods identified that were ICI recurrent or metastatic setting after progression platinum-based chemotherapy two independent centers....
Rapid histologic diagnosis of frozen sections is essential for a variety surgical procedures. Frozen however, require specialized lab equipment, are prone to freezing artifacts and not applicable all types tissue. Adipose tissue especially difficult process in sections. Although these limitations well known, no alternative method microscopic analysis that might replace could be established. Our objective was evaluate whether imaging based on ex vivo fluorescent confocal microscopy (FCM)...
Rapid microscopic analysis of tissue is an essential diagnostic tool in oncological surgery. The gold standard for intraoperative histological evaluation frozen sections. However, sections are prone to a variety artefacts and require skilled staff specialized lab equipment. A potential method rapid that does not fixation, freezing, or sectioning the ex vivo fluorescence confocal microscopy (FCM). visualization structurally important extracellular matrix (ECM) conventional FCM lags behind...
Interstitial fibrosis (IF) is the common pathway of chronic kidney injury in various conditions. Magnetic resonance imaging (MRI) may be a promising tool for noninvasive assessment IF renal allografts.This prospective trial was primarily designed to investigate whether results T1-weighted MRI associate with degree IF. Thirty-two transplant recipients were subjected 1.5-Tesla scans shortly before or after routine allograft biopsies. parameters [T1 and T2 relaxation times; apparent diffusion...
Abstract Objective Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold by open (OAR) or endovascular repair. So far, attempts for medical growth abrogation have failed. This study aims to elucidate the heterogeneity of AAA based on histomorphology in correlation individual patient data and metrics. Patients Methods Aneurysm samples from left anterior wall four university center biobanks underwent histologic analysis including angiogenesis, calcification, fibrosis, type...
Abstract Computational analysis of histopathological specimens holds promise in identifying biomarkers, elucidating disease mechanisms, and streamlining clinical diagnosis. However, the application deep learning techniques vascular pathology remains underexplored. Here, we present a comprehensive evaluation learning-based approaches to analyze digital whole-slide images abdominal aortic aneurysm samples from 369 patients three European centers. Deep demonstrated robust performance predicting...
Rapid microscopic analysis of tissue is an essential diagnostic tool in oncological surgery. The gold standard for intraoperative histological evaluation are frozen sections. However, sections prone to a variety artefacts and require skilled staff specialized lab equipment. A potential method rapid that does not fixation, freezing nor sectioning the tissue, ex vivo fluorescence confocal microscopy (FCM). visualization structurally important extracellular matrix (ECM) conventional FCM lags...
This case report is about a 47-year-old patient, who was diagnosed with intracardiac intravenous leiomyomatosis and received treatment at our institution. Intravenous rare, histologically benign, uterine neoplasm, which characterized by non-invasive intravascular proliferation of smooth muscle cells. arises from the myometrium and, in its most extensive form, can reach heart via pelvic veins inferior vena cava, causing hemodynamic complications. Treatment choice complete resection tumor,...
ObjectiveCarotid atherosclerosis is an important cause of cerebral ischaemic stroke. Sonographic plaque characteristics are inappropriate for exact prediction possible future events. Additional markers needed to predict the clinical outcome in high grade carotid stenosis. This study aimed test extracellular matrix metalloproteinase inducer (EMMPRIN), due its involvement formation and destabilisation, as a potential marker risk vulnerable plaques.MethodsEMMPRIN was analysed pre-operative...
Interleukin (IL-33) and the ST2 receptor are implicated in pathogenesis of atherosclerosis. Soluble (sST2), which negatively regulates IL-33 signaling, is an established biomarker coronary artery disease heart failure. Here we aimed to investigate association sST2 with carotid atherosclerotic plaque morphology, symptom presentation, prognostic value patients undergoing endarterectomy. A total 170 consecutive high-grade asymptomatic or symptomatic stenosis endarterectomy were included study....
Abdominal aortic aneurysm (AAA) is a pathologic enlargement of the infrarenal aorta with an associated risk rupture. However, responsible mechanisms are only partially understood. Based on murine and human samples, heterogeneous distribution characteristic features across circumference expected. Yet, complete histologic workup sac scarcely reported. Here, samples from five AAAs covering as rings investigated by means (HE, EvG, immunohistochemistry) new method embedding ring. Additionally,...
Abdominal aortic aneurysms (AAA) are the most frequent dilation, with considerable morbidity and mortality. Inflammatory (infl) IgG4-positive AAAs represent specific subtypes of unclear incidence clinical significance. Here, histologic serologic analyses retrospective data acquisition investigated via detailed histology, including morphologic (HE, EvG: inflammatory subtype, angiogenesis, fibrosis) immunhistochemic (IgG IgG4). In addition, complement factors C3/C4 immunoglobulins IgG, IgG2,...
(Pre-)Implantation biopsies provide important data on the quality of donor kidneys. Interstitial fibrosis, as a known predictor for kidney disease progression, is an essential feature this evaluation. However, assessment frozen sections implantation challenging and can result in disposal candidate organs. We sought to apply digital image analysis (DIA) quantify differences between paraffin when evaluating interstitial identify factors that influence these variations test predictive value...
Abstract Aging, the predominant risk factor for numerous diseases, manifests in various forms across structure and architecture of tissues human body, offering opportunity to quantify interpret tissue-specific aging. To address this, we present a comprehensive assessment tissue changes occurring during aging, utilizing vast array whole slide histopathological images from Genotype-Tissue Expression Project (GTEx). We analyzed 25,712 40 distinct types 983 individuals, applying deep learning...
Summary Monoclonal gammopathy of renal significance (MGRS) encompasses a group kidney disorders in which monoclonal immunoglobulin secreted by B cell or plasma clone causes damage, without meeting hematological criteria for malignancy. The underlying disorder patients with MGRS is generally consistent undetermined (MGUS). Because the wide spectrum MGRS-associated diseases, defined through location and mechanism injury, it often challenging to establish right diagnosis. Kidney biopsy must be...
Enterococcal infections comprise a considerable threat to cirrhotic patients, since enterococci are often insusceptible (i.e. cephalosporins, carbapenems) or becoming increasingly resistant (e.g. aminopenicillins) recommended antibiotics.
e18527 Background: Biomarkers for response prediction to immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) patients are needed a personalized therapy regimen. Therefore, we investigated the predictive potential of inflammatory biomarkers DNA methylation. Methods: We profiled methylation status 850.000 CpG sites formalin-fixed, paraffin-embedded primary HNSCC samples collected before ICI start using Infinium Methylation EPIC microarrays. Tumor-infiltrating...
Einleitung Die intravenöse Leiomyomatose (IVL) ist eine seltene Erkrankung, welche durch nicht-invasives, intravaskuläres, Wachstum glatter Muskelzellen gekennzeichnet ist. Ihr Ursprung liegt meist in einer uterinen Leiomyomatose. In ihrer ausgedehntesten Form kann die IVL über Gefäße und Vena cava inferior (VCI) rechte Herzkammer erreichen. Klinik der, histologisch benignen, ähnelt der eines Malignoms kann, aufgrund von Herzstillstand, Organversagen, Therapie-assoziierten Komplikationen...