A5043839529- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Medication Adherence and Compliance
- Virology and Viral Diseases
- Mobile Health and mHealth Applications
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical studies and practices
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Organ Donation and Transplantation
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Health Literacy and Information Accessibility
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Renal and Vascular Pathologies
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
Medical University of Vienna
2020-2024
The nonpathogenic and ubiquitous torque teno virus (TTV) is associated with immunosuppression in solid organ transplant recipients. Studies kidney patients proposed TTV quantification for risk stratification of graft rejection infection. In this prospective trial (DRKS00012335) 386 consecutive recipients were subjected to longitudinal per-protocol monitoring plasma load by polymerase chain reaction 12 months posttransplant. peaked at the end month 3 posttransplant reached steady state...
Abstract Background Immunosuppression after kidney transplantation is mainly guided via plasma tacrolimus trough level, which cannot sufficiently predict allograft rejection and infection. The load of the non-pathogenic highly prevalent torque teno virus (TTV) associated with immunosuppression its host. Non-interventional studies suggest use TTV to primary objective current trial demonstrate safety, tolerability preliminary efficacy TTV-guided immunosuppression. Methods For this purpose, a...
Torque Teno virus (TTV) is nonpathogenic, highly prevalent, and reflects the immune status of its host. Thus, TTV plasma load was suggested for guidance immunosuppression post solid organ transplantation. The present study designed to determine kinetics following changes in calcineurin inhibitor (CNI) dose. A total 48 adult recipients a kidney graft transplanted at Medical University Vienna between 2018 2019 with isolated CNI dose were selected from prospective TTV-POET trial. quantified by...
Nonpathogenic torque teno viruses (TTVs) are highly prevalent in transplant recipients and associated with immunosuppression. Studies kidney patients have proposed assessment of TTV load for risk stratification clinically overt graft rejection. The value quantification the context subclinical rejection has not been evaluated.In this prospective trial, 307 consecutive were subjected to per-protocol monitoring plasma TTV. was analyzed protocol biopsies (n = 82), scheduled 1 year...
Torque Teno virus (TTV) is non-pathogenic, highly prevalent and reflects the immune status of its host. TTV plasma load was suggested for risk stratification graft rejection infection post kidney-transplantation, which most studies applied an in-house PCR. Recently, a commercial PCR CE-certified clinical use. The present study designed to assess performance as quantified by in prediction infection. Patients events were selected from prospective TTV-POET trial, including 683 consecutive adult...
IntroductionEarlier reports suggest that patients after ABO-incompatible kidney transplantation (ABOi) are at enhanced risk to develop BK-virus (BKV) nephropathy (BKPyVAN). It remains elusive whether this is a result of more intense immunosuppression or an ABOi-associated 'intrinsic attribute'. To address question, we measured Torque-Teno-Virus (TTV) loads as quantitative proxy for immunosuppressive depth in ABOi recipients and compared them HLA-incompatible (HLAi, i.e. pre-transplant...
Introduction An online interactive repository of available medication adherence technologies may facilitate their selection and adoption by different stakeholders. Developing a is among the main objectives European Network to Advance Best practices technoLogy on adherencE (ENABLE) COST Action (CA19132). However, meeting needs diverse stakeholders requires careful consideration structure. Methods analysis A real-time Delphi study from 39 countries with research, practice, policy, patient...
The introduction of calcineurin inhibitor (CNI)–based immunosuppression in the 1980s significantly reduced acute graft rejection after solid organ transplantation (SOT). During past 40 y, this immunosuppressive regimen has remained largely unchanged, and it is unlikely that new drugs will drastically alter routine care next decades. However, SOT still faces 2 major challenges: chronic opportunistic infections, both which result from inappropriate dosed immunosuppression. Because...
Abstract Background and Aims Adherence towards immunosuppressive medication is crucial for allograft survival after renal transplantation. However, its assessment in daily clinical practice remains challenging. The BAASIS© questionnaire, a validated self-report instrument to detect non-adherence. predictive validity relevant consequences of non-adherence needs be established. Method prospective AdTorque-trial (DRKS00026674) includes consecutive cohort 226 adult kidney graft recipients...
Obesity affects a rising proportion of the population and is an important risk factor for unfavorable outcomes in viral disease including severe acute respiratory syndrome coronavirus 2- associated diseases. Torque Teno virus (TTV) ubiquitous apathogenic which reflects immune function its host. The aim this study was to investigate association between obesity TTV load - indirect marker compromised response. quantified by R-GENE® PCR total 89 participants 30 were lean (BMI <25 kg/m2) 59 obese...
<sec> <title>BACKGROUND</title> Technology-mediated medication adherence interventions have proven useful, yet implementation in clinical practice is low. The ENABLE COST Action (CA19132) online repository of technologies (MATech) aims to provide an open access, searchable knowledge management platform facilitate innovation and support across health systems. To a solid foundation for optimal use collaboration, the requires shared interdisciplinary terminology. </sec> <title>OBJECTIVE</title>...
Technology-mediated medication adherence interventions have proven useful, yet implementation in clinical practice is low. The European Network to Advance Best Practices and Technology on Medication Adherence (ENABLE) Cooperation Science Action (CA19132) online repository of technologies (MATechs) aims provide an open access, searchable knowledge management platform facilitate innovation support across health systems. To a solid foundation for optimal use collaboration, the requires shared...
Background. Pretransplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and of deceased donors are not available. Methods. In this prospective study, we analyzed 147 pretransplant from 88 adult procured transplanted consecutively at Medical University Vienna July 2017 May 2020. Lesions in each renal compartment were scored 0 to 5 with ascending score representing a 20% increase damage. A chronic lesions was...
Abstract Background Immunosuppression after kidney transplantation is mainly guided via plasma tacrolimus trough level, which cannot sufficiently predict allograft rejection and infection. The load of the non-pathogenic highly prevalent Torque Teno Virus (TTV) associated with immunosuppression its host. Non-interventional studies suggest use TTV to primary objective current trial demonstrate safety, tolerability preliminary efficacy TTV-guided immunosuppression. Methods For this purpose, a...
Abstract BACKGROUND AND AIMS The nonpathogenic and ubiquitous Torque Teno virus (TTV) plasma load is associated with immunosuppression in solid organ transplant recipients. An optimal TTV range has been defined for risk stratification of graft rejection infection the first year post kidney applying an in-house PCR. Recently, a commercial PCR—the R-GENE® kit—has CE certified clinical use. present study was designed to validate refine kit. METHOD Patients events were selected from prospective...
Abstract BACKGROUND AND AIMS The apathogenic and torque teno virus (TTV) is associated with the state of immunosuppression in solid organ transplant recipients. After kidney transplantation, quantification TTV viral load may serve as a risk stratification tool for allograft rejection infectious events. Besides robust independent association between recipient age, sex load, respectively, limited data exists on other potential determinants load. This trial was designed to analyse detailed...