A5091983528- IL-33, ST2, and ILC Pathways
- Biomarkers in Disease Mechanisms
- Protease and Inhibitor Mechanisms
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
Medical University of Vienna
2023
Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, cardiovascular outcomes.
Interleukin (IL-33) and the ST2 receptor are implicated in pathogenesis of atherosclerosis. Soluble (sST2), which negatively regulates IL-33 signaling, is an established biomarker coronary artery disease heart failure. Here we aimed to investigate association sST2 with carotid atherosclerotic plaque morphology, symptom presentation, prognostic value patients undergoing endarterectomy. A total 170 consecutive high-grade asymptomatic or symptomatic stenosis endarterectomy were included study....