A5015669479- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Insect and Arachnid Ecology and Behavior
- Respiratory viral infections research
- Plant and animal studies
- Animal Behavior and Reproduction
- Cancer Genomics and Diagnostics
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Cancer Cells and Metastasis
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Vector-Borne Animal Diseases
- COVID-19 epidemiological studies
- Virus-based gene therapy research
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Neuroendocrine Tumor Research Advances
IMC University of Applied Sciences Krems
2024
Comprehensive Cancer Center Vienna
2018-2024
Medical University of Vienna
2010-2024
Austrian Agency for Health and Food Safety
2020-2023
University of Miami
2022
Sri Lanka Institute of Nanotechnology
2022
Gesundheit Österreich
2021
The Pirbright Institute
2011-2021
University of Lausanne
2006-2009
Ludwig Boltzmann Cluster for Cardiovascular Research
2009
ABSTRACT We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human rhinovirus, coxsackievirus, mengovirus multiplication. Early stages of virus infection are unaffected by these compounds. However, the cleavage cellular eukaryotic translation initiation factor eIF4GI rhinoviral 2A protease was abolished in presence PT HK. further show compounds picornavirus replication interfering with proper processing viral polyprotein. In...
Abstract Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections cause disease 2019 (COVID-19) and induce a specific antibody response. Serological assays detecting IgG against the receptor binding domain (RBD) of spike (S) protein are useful to monitor immune response after infection or vaccination. The objective our study was evaluate clinical performance Siemens SARS-CoV-2 (sCOVG) assay. Methods Sensitivity specificity sCOVG test were evaluated on 178 patients...
Polycomb group (PcG) proteins form chromatin-associated, transcriptionally repressive complexes, which are critically involved in the control of cell proliferation and differentiation. Although mechanisms PcG-mediated repression beginning to unravel, little is known about regulation PcG function. We showed previously that complexes phosphorylated vivo, regulates their association with chromatin. The nature responsible kinases remained unknown. Here we present novel finding protein Bmi1 by...
The condition dependence of sexually selected traits is an important assumption sexual selection theory. Several laboratory studies have documented a positive relationship between food availability, body condition, and display. However, these might not reflect the resource allocation maintenance, reserves, trait under natural conditions. Further, effect condition-dependent signaling on female mate choice has hardly been investigated experimentally in field. We therefore availability calling...
Abstract Influenza is a major health threat, and broadly protective influenza vaccine would be significant advance. Signal Minus FLU (S-FLU) candidate that limited to single cycle of replication, which induces strong cross-reactive T cell response but minimal Ab hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs ferrets from heterosubtypic H1N1 challenge. Aerosol administration induced lung tissue-resident memory cells reduced pathology...
According to the European Public Health Authority guidance for ending isolation in context of COVID-19, a convalescent healthcare worker (HCW) can end their at home and resume work upon clinical improvement two negative RT-PCR tests from respiratory specimens obtained 24-h intervals least 8 days after onset symptoms. However, HCWs may shed SARS-CoV-2 viral RNA prolonged periods.40 healthy off because ongoing positive results combined nasopharyngeal (NP) oropharyngeal (OP) swabs following...
Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection or vaccination. While first-generation antibody have primarily provided qualitative results, accurate seroprevalence studies and tracking of levels over time require highly specific, sensitive quantitative test setups.
Abstract Some ants have an extraordinary form of social organization, called unicoloniality, whereby individuals mix freely among physically separated nests. This mode organization has been primarily studied in introduced and invasive ant species, so that the recognition ability genetic structure forming unicolonial populations their native range remain poorly known. We investigated pattern aggression six Formica paralugubris at four hierarchical levels: within nests, nests same population,...
Abstract Small‐cell lung cancer (SCLC) is a fatal disease with limited treatment options. Circulating tumor cells (CTCs) in liquid biopsy samples may serve as predictive and prognostic biomarkers; but the analysis of CTCs still challenging. By using microfluidic or density gradient CTC enrichment combination immunofluorescent (IF) staining qPCR CTC‐related transcripts, we achieved 60.8% to 88.0% positivity SCLC blood samples. Epithelial neuroendocrine transcripts including druggable target...
Abstract Objective The purpose of this article is to review the surgical management and outcome toxic megacolon update aetiology megacolon. Patients method A retrospective chart three academic colorectal surgery units was undertaken. Over a period 20 years, 70 patients with surgically managed were identified: 32 men 38 women, median age 63 years (range, 23–87 years). Results In 33 (48%) main cause inflammatory bowel disease. Thirty‐seven (52%) had different aetiology. Sixty‐three underwent...
Abstract Background Animal societies are diverse, ranging from small family-based groups to extraordinarily large social networks in which many unrelated individuals interact. At the extreme of this continuum, some ant species form unicolonial populations workers and queens can move among multiple interconnected nests without eliciting aggression. Although unicoloniality has been mostly studied invasive ants, it also occurs native non-invasive species. Unicoloniality is commonly associated...
Abstract Objective Pilonidal sinus is common. It causes substantial loss of working hours. The major disadvantage open wound treatment the long time required for healing. Primary closure on other hand often followed by infection. A controlled, multicentre trial was carried out to evaluate efficacy a new gentamicin collagen fleece (Septocoll ® ) combined with primary closure. Patients and methods One hundred three patients (88 men, 15 women, median age 30 years) were included. Fifty‐one...
In animal societies, cooperation for the common wealth and latent conflicts due to selfish interests of individuals are in delicate balance. many ant species, colonies contain multiple breeders workers interact with nestmates varying degrees relatedness. Therefore, could increase their inclusive fitness by preferentially caring closest relatives, yet evidence nepotism insect societies remains scarce controversial. We experimentally demonstrate that Formica exsecta do not discriminate between...
The Nairoviruses are an important group of tick-borne viruses that includes pathogens man (Crimean Congo hemorrhagic fever virus) and livestock animals (Dugbe virus, Nairobi sheep disease virus (NSDV)). NSDV is found in large parts East Africa the Indian subcontinent (where it known as Ganjam virus). We have investigated ability to antagonise induction actions interferon. Both pathogenic apathogenic isolates could actively inhibit type 1 interferon, also blocked signalling pathways both 2...
Despite recent advances in the treatment of non-small cell lung cancer (NSCLC), less than 10% patients survive first five years when disease has already spread at primary diagnosis.Blood samples were taken from 118 NSCLC diagnosis or progression before start a new line and enriched for circulating tumor cells (CTCs) by microfluidic Parsortix™ (Angle plc, Guildford GU2 7AF, UK) technology. The gene expression epithelial stem (CSC), to mesenchymal (EMT), lung-related markers was assessed qPCR,...
Pyrrolidine dithiocarbamate (PDTC) is an antiviral compound that was shown to inhibit the replication of human rhinoviruses (HRVs), poliovirus, and influenza virus. To elucidate mechanism PDTC, effects on individual steps infection cycle HRV were investigated. PDTC did not interfere with receptor binding or internalization by mediated endocytosis HRV2 particles into HeLa cells. But we demonstrate processing viral polyprotein prevented treatment in cells infected HRV2. Furthermore, inhibited...
Influenza virus infection is a significant global health threat. Because of the lack cross protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies required. Broadly cross-protective antibodies that target conserved sites in hemagglutinin (HA) stem region, have been proposed as agents. FI6 first proven such monoclonal antibody to bind H1-H16 mice ferrets. Multiple studies shown Fc-dependent...
Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions both directions. The emergence 2009 pandemic H1N1 illustrates importance pigs zoonotic strains. Here we generated pig influenza-specific monoclonal antibodies (mAbs) from H1N1pdm09 infected pigs. mAbs recognized two major immunodominant haemagglutinin (HA) epitopes targeted by humans, one which is not post-infection ferret antisera...
Abstract Partly due to climate change, and partly changes of human habitat occupation, the impact tick-borne viruses is increasing. Nairobi sheep disease virus (NSDV) Ganjam (GV) are two names for same virus, which causes in goats currently known be circulating India East Africa. The transmitted by ixodid ticks a severe hemorrhagic disease. We have developed real-time PCR assay genome validated it pilot study pathogenicity induced different isolates NSDV/GV. One isolate was highly adapted...
The ovarian tumour (OTU) domain of the nairovirus L protein has been shown to remove ubiquitin and interferon-stimulated gene 15 (ISG15) from host cell proteins, which is expected have multiple effects on signalling pathways. We confirmed that OTU apathogenic Dugbe virus deubiquitinating deISGylating activity that, when expressed in cells, it highly effective at blocking TNF-α/NF-κB interferon/JAK/STAT pathways even low doses. Point mutations catalytic site [C40A, H151A a double mutant] both...