A5049725450- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Cancer Mechanisms and Therapy
- Ion channel regulation and function
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Neuroscience and Neuropharmacology Research
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- Gastrointestinal Tumor Research and Treatment
- Nicotinic Acetylcholine Receptors Study
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Immune Cell Function and Interaction
- Uterine Myomas and Treatments
- Cancer-related gene regulation
Innsbruck Medical University
2012-2024
Universität Innsbruck
1996-2024
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2012-2020
AGO Austria
2018-2020
University of Nevada, Reno
2010-2017
University Hospital Innsbruck
2012-2016
Charité - Universitätsmedizin Berlin
2014
Medical University of Vienna
2011-2013
University Hospital Heidelberg
2013
Radboud University Nijmegen
2013
In cochlea inner hair cells (IHCs), L-type Ca2+ channels (LTCCs) formed by α1D subunits (D-LTCCs) possess biophysical and pharmacological properties distinct from those of α1C containing C-LTCCs. We investigated to which extent these differences are determined itself analyzing the cloned human splice variants in tsA-201 cells. Variant α1D8A,containing exon 8A sequence repeat I, yielded protein currents, whereas no intact currents were observed after expression with 8B. whole cell patch-clamp...
The spontaneous activity of pacemaker cells in the sino-atrial node (SAN) controls heart rhythm and rate under physiological conditions. Pacemaker SAN is due to presence diastolic depolarization, a slow depolarization phase that drives membrane voltage from end an action potential threshold new potential. express wide array ionic channels, but we have limited knowledge about their functional role still do not know which channels play prominent generation depolarization. It thus important...
Despite the excellent prognosis of Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, type I endometrial cancers, a substantial number patients experience recurrence and die from this disease. We analyzed value immunohistochemical L1CAM determination to predict clinical outcome.We conducted retrospective multicenter cohort study determine expression by immunohistochemistry in 1021 cancer specimens. The Kaplan-Meier method Cox proportional hazard model were applied for...
Abstract Purpose: The major obstacle in treating ovarian cancer is the rapid development of platinum resistance during therapy. Deregulation members E2F family transcription factors crucially involved carcinogenesis and probably mechanisms underlying resistance. We therefore investigated relevance whole set predicting clinical outcome their significance Experimental Design: Real-time PCR all was done from 77 carcinomas, defined as our training set, 8 healthy control samples. correlation with...
// Maximilian Boesch 1,2 , Alain G. Zeimet 3 Daniel Reimer Stefan Schmidt 1 Guenther Gastl Walther Parson 4 Franziska Spoeck Jiri Hatina 5 Dominik Wolf 1,6,* Sieghart Sopper 1,2,* Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria 2 Tyrolean Cancer Research Institute, Department of Gynecology and Obstetrics, Institute Legal Medicine, Biology Biomedical Centre, Faculty Pilsen, Charles University Prague, Czech Republic 6 Clinic III, Oncology, Hematology Rheumatology, Bonn...
An increasing body of evidence shows that miR-34 family has tumor suppressive properties mediating apoptosis, cell cycle arrest and senescence. In ovarian cancer, miR34 members were found to be under expressed. Particularly miR-34a been revealed a direct transcriptional target p53 which is frequently mutated in epithelial carcinomas especially high grade serous cancer. Moreover, methylation CpG Islands was down-regulate expression. The aim this study investigate the clinical relevance mir34a...
Heterologous expression studies have shown that the activity of voltage-gated Ca2+ channels is regulated by their β subunits in a subunit isoform-specific manner. In this study we therefore investigated if one or several isoforms associate with L-type different regions mammalian brain.All four (β1b, β2, β3, and β4) are expressed cerebral cortex as immunoblots. Immunoprecipitation (+)-[3H]isradipine-labeled revealed majority subunit-associated was associated β3 (42 ± 8%) β4 7%) subunits,...
The neuronal L-type calcium channels (LTCCs) Ca v 1.2α1 and 1.3α1 are functionally distinct. activates at lower voltages inactivates more slowly than 1.2α1, making it suitable to support sustained 2+ inward currents ( I Ca,L ) serve in pacemaker functions. We compared the biophysical pharmacological properties of human retinal 1.4α1 using whole-cell patch-clamp technique after heterologous expression tsA-201 cells with other α1 subunits. 1.4α1-mediated Ba required coexpression α2δ1 β3 or β2a...
Abstract Purpose: We aimed to determine the clinical role of p53 family members and p73 in responsiveness platinum-based chemotherapy survival ovarian cancer, considering their cross-talk polymorphism at codon 72. Experimental Design: A detailed analysis a series 122 cancers was done. used functional yeast-based assay mutational status. Red yeast colonies, indicating mutant p53, were subsequently sequenced specific alteration. mutations divided into two groups according previous...
Toll‐like receptor 9 (TLR9) activates the innate immune response when exposed to non‐methylated CpG‐DNA. TLR9 was recently shown be expressed by cancer cells which have been previously characterized global hypomethylation. We set out examine expression and molecular activity of in breast ovarian cells. Firstly, we confirmed higher levels hypomethylated DNA serum patients with metastatic ( n = 18) versus age‐matched tumor‐free women 18). In cell lines tissues, mRNA associated...
Social responsibility looms as a key feature of leadership decision making and citizenship behavior the world's resources are depleted, health education crises increase, communities, societies, cultures adapt to new context shaped by emerging technologies, political upheavals, global warming, other drivers change. In this article we call for future work in analysis, emphasizing importance organizational leaders' decision-making behaviors establishing practices that support prosocial...
Ovarian cancer (OC) is the most lethal gynecological malignancy, with platinum-based chemotherapy remaining mainstay for adjuvant treatment after surgery. The lack of indication immunotherapy may at least in part result from suitable biomarkers allowing stratification potentially responding patients. In this monocentric study 141 cases OC, we used real-time quantitative PCR to assess expression retinoic acid-inducible gene-I (RIG-I) primary tumor and healthy ovarian control tissues. RIG-I...
Epithelial ovarian cancer (OC) is the deadliest gynecological malignancy worldwide. Blocking angiogenesis with bevacizumab, an antibody targeting vascular endothelial growth factor (VEGF), shows efficacy in different lines of OC therapy. This study investigates clinical impact tumoral expression angiogenesis-related genes and their association bevacizumab response retrospective analysis three independent cohorts.mRNA seven angiogenic (VEGF, VEGFR2, PDGFA, PDGFB, PDGFRA, PDGFRB, KIT) was...
Abstract: The E2F family of transcription factors plays a pivotal role in the regulation cellular proliferation. On basis sequence homology and function, eight distinct members (E2F‐1 to E2F‐8) have been distinguished date. is closely associated with function retinoblastoma tumor suppressors (RB pathway). In last decade various alterations components RB‐E2F pathway were found be progression. However, no data on are available biology ovarian cancer. Here we describe an expression study human...
The tumor suppressor p53 generates the N-terminally truncated isoforms Δ40p53 and Δ133p53 that possess ability to modulate function in vitro. aim of present study was evaluate clinical relevance main histological subtypes ovarian cancer.Δ40p53, Δ133p53, full-length (FLp53) expression determined 45 mucinous, 30 endometrioid, 91 serous cancer specimens as well 42 normal tissues using reverse transcriptase-quantitative polymerase chain reaction. In a subgroup mucinous cases, examined Western...
We describe for the first time a new integral molecular pathway, linking transcription factor E2F3a to epidermal growth receptor (EGFR) activation in ovarian cancer cells. Investigations on role of E2F family members EGFR-mediated mitogenic signaling revealed that was selectively upregulated following EGFR activation, whereas all other remained unaffected. In contrast, EGF treatment healthy surface epithelial and mesothelial cells yielded selective upregulation proliferation-promoting E2F1...