A5030917553- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Chemical Sensor Technologies
- Fatty Acid Research and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Pulmonary Hypertension Research and Treatments
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Olfactory and Sensory Function Studies
- SARS-CoV-2 detection and testing
- Data-Driven Disease Surveillance
- Cholesterol and Lipid Metabolism
- Mobile Health and mHealth Applications
- Eicosanoids and Hypertension Pharmacology
- Sepsis Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
Innsbruck Medical University
2015-2025
Universität Innsbruck
2017-2024
Azienda Sanitaria di Firenze
2023
Molina Center for Energy and the Environment
2019
University Hospital Innsbruck
2014
Santa Maria Nuova Hospital
2013
Austrian Academy of Sciences
2009
Background After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term sequelae coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data lacking. Methods In this prospective, multicentre, observational study, we systematically evaluated cardiopulmonary damage in subjects recovering from COVID-19 at 60 100 days after confirmed diagnosis. We conducted a detailed...
The Coronavirus Disease 2019 (COVID-19) pandemic increases the demand for postacute care in patients after a severe disease course. Various long-term sequelae are expected and rehabilitation medicine is challenged to support physical cognitive recovery.We aimed explore dysfunctions outcome of COVID-19 survivors early rehabilitation.Observational cohort study.This study evaluated hospitalized SARS-CoV-2 infection analyzed rehabilitative outcomes subgroup included prospective observational...
To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19.In this prospective, multicenter, observational cohort study we systematically evaluated signs diseases by detailed examination a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assessment), QoL (36-item Short Form), mental health (Hospital Anxiety Depression Scale, Posttraumatic Stress Disorder Checklist-5) disease...
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of disease 139 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts enzyme activities, well untargeted plasma proteomes at 687 sampling points. report an initial spike a systemic inflammatory response, which gradually alleviated followed protein signature indicative tissue repair,...
Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter related to increased mortality in COVID-19. Still, it not clear if iron dysmetabolism mechanistically linked COVID-19 pathobiology.We herein present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number, NCT04416100), which systematically follows up patients after 109 participants were evaluated 60 days onset of...
Background The long-term pulmonary sequelae of COVID-19 is not well known. Purpose To characterize patterns and rates improvement chest CT abnormalities 1 year after pneumonia. Materials Methods This was a secondary analysis prospective, multicenter observational cohort study conducted from April 29 to August 12, 2020, assess at approximately 2, 3, 6 months onset symptoms. Pulmonary findings were graded for each lung lobe using qualitative severity score (CTSS) ranging 0 (normal) 25 (all...
The present study was performed to determine the variations of breath acetone concentrations with age, gender and body-mass index (BMI). Previous investigations were based on a relatively small cohort subjects (see Turner et al 2006 Physiol. Meas. 27 321-37). Since exhaled analysis is affected by considerable variation, larger studies are needed get reliable information about correlation volatiles in when compared BMI. Mixed expiratory sampled using Tedlar bags. mass-to-charge ratio (m/z)...
Breath analysis for the purpose of non-invasive diagnosis lung cancer has yielded numerous candidate compounds with still questionable clinical relevance. To arrive at suitable volatile organic our approach combined different sources: isolated tumor samples compared to healthy tissues, and exhaled breath from patients controls. Candidate were further substances previously identified in comparison transformed normal epithelial cell lines. For human studies, a sampling device was developed...
The novel Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a global health concern. Vitamin D (VITD) deficiency has been suggested to alter SARS-CoV-2 susceptibility and the course of disease. Thus, we aimed investigate associations VITD status presentation within CovILD registry. This prospective, multicenter, observational study on long-term sequelae includes patients with COVID-19 after hospitalization or outpatients...
Abstract Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections cause disease 2019 (COVID-19) and induce a specific antibody response. Serological assays detecting IgG against the receptor binding domain (RBD) of spike (S) protein are useful to monitor immune response after infection or vaccination. The objective our study was evaluate clinical performance Siemens SARS-CoV-2 (sCOVG) assay. Methods Sensitivity specificity sCOVG test were evaluated on 178 patients...
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such SOFA APACHE II scores show only limited performance for predicting survival severely ill patients. Additional tools also needed monitor treatment, including experimental therapies clinical trials. Comprehensively capturing human physiology, we speculated that proteomics combination with new...
Background: The optimal procedures to prevent, identify, monitor, and treat long-term pulmonary sequelae of COVID-19 are elusive. Here, we characterized the kinetics respiratory symptom recovery following COVID-19. Methods: We conducted a longitudinal, multicenter observational study in ambulatory hospitalized patients recruited early 2020 (n = 145). Pulmonary computed tomography (CT) lung function (LF) readouts, prevalence, clinical laboratory parameters were collected during acute at 60,...
Although chronic obstructive pulmonary disease (COPD) prevalence and mortality rates rise continuously, patients often remain undiagnosed, probably due to a lack of disease-related awareness. The aim this study was quantify public interest in COPD by analysing the frequency web queries via Google.Data from 2004 2018 were collected using search engine query data analysis tool Google Trends. relative volume topic "chronic disease" compared with nine topics representing major causes death...
Chronic obstructive pulmonary disease (COPD) is a major cause of death worldwide. Acute exacerbations COPD (AECOPD), caused by infectious and non-infectious agents, contribute to an increase in mortality. The diagnostic procedure AECOPD mainly based on clinical features. aim this pilot study was identify whether volatile organic compounds (VOCs) breath could be used discriminate for acute exacerbated COPD. Three patient groups were included controlled study: patients (n = 14, age mean ± SD:...
Coronavirus Disease-19 (COVID-19) convalescents are at risk of developing a de novo mental health disorder or worsening pre-existing one. COVID-19 outpatients have been less well characterized than their hospitalized counterparts. The objectives our study were to identify indicators for poor following outpatient management and high-risk individuals.We conducted binational online survey with adult non-hospitalized (Austria/AT: n = 1,157, Italy/IT: 893). Primary endpoints positive screening...
Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary mental health recovery up 1 year following COVID-19.Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) transthoracic echocardiography were conducted at 2, 3, 6 12 months after onset. Submaximal exercise capacity, quality life assessed months. patterns investigated by mixed-effect...
Fatigue, sleep disturbance, and neurological symptoms during after COVID-19 are common might be associated with inflammation-induced changes in tryptophan (Trp) phenylalanine (Phe) metabolism.This pilot study investigated interferon gamma inducible biochemical pathways (namely Trp catabolism, neopterin, tyrosine [Tyr], nitrite formation) acute reconvalescence.Thirty one patients moderate to severe admitted the University Hospital of Innsbruck early 2020 (March-May) were followed up....
Long COVID, defined as the presence of coronavirus disease 2019 (COVID-19) symptoms ≥28 days after clinical onset, is an emerging challenge to healthcare systems. The objective current study was explore recovery phenotypes in nonhospitalized individuals with COVID-19.A dual cohort, online survey conducted between September 2020 and July 2021 neighboring European regions Tyrol (TY; Austria, n = 1157) South (STY; Italy, 893). Data were collected on demographics, comorbid conditions, COVID-19...
To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental physical subcategories 3 months after diagnosis COVID-19.
Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter related to acute severity and COVID-19 convalescence. We herein describe dyshomeostasis at follow-up its association long-term pulmonary symptomatic recovery. prospective, multicentre, observational cohort study "Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (CovILD)" encompasses serial extensive clinical, laboratory, functional imaging evaluations...
Objectives: Prediction of lung function deficits following pulmonary infection is challenging and suffers from inaccuracy. We sought to develop machine-learning models for prediction post-inflammatory changes based on COVID-19 recovery data. Methods: In the prospective CovILD study (n = 420 longitudinal observations n 140 survivors), data testing (LFT), chest CT including severity scoring by a human radiologist density measurement artificial intelligence, demography, persistent symptoms were...