Philipp Knape
A5067013700- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Hormonal and reproductive studies
- Pneumothorax, Barotrauma, Emphysema
- Sexual Differentiation and Disorders
- Cardiac Arrhythmias and Treatments
- Surgical site infection prevention
- Pericarditis and Cardiac Tamponade
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Abdominal Surgery and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Metastasis and carcinoma case studies
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Glioma Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Syncope and Autonomic Disorders
- Liver Disease Diagnosis and Treatment
Charité - Universitätsmedizin Berlin
2008-2024
Humboldt-Universität zu Berlin
2020-2024
Freie Universität Berlin
2020-2024
Deutsches Herzzentrum der Charité
2023
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of disease 139 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts enzyme activities, well untargeted plasma proteomes at 687 sampling points. report an initial spike a systemic inflammatory response, which gradually alleviated followed protein signature indicative tissue repair,...
In face of the Coronavirus Disease (COVID)-19 pandemic, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, rationale high positive end-expiratory pressure (PEEP) and prone positioning early ARDS has been questioned.The first 23 consecutive patients with respiratory failure transferred to a single ICU were assessed. Eight excluded: five not invasively ventilated three received veno-venous ECMO support....
Abstract Background Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim this study was estimate the frequency and outcome COVID-19 sequela identify possible risk factors. Methods This observational study, conducted at University Hospital Charité Berlin Unfallkrankenhaus Berlin, Germany, involved hospitalized patients with pneumonia, including 1082 ventilated...
Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical virological disease trajectories. The purpose this work was to identify risk factors associated with need invasive mechanical ventilation (IMV), analyse viral kinetics patients without IMV provide a comprehensive description course.A cohort 168 hospitalised adult COVID-19 enrolled prospective observational study at large European tertiary care...
Dexamethasone has become the standard of care for severe coronavirus disease 2019 (COVID-19), but its virological impact is poorly understood. The objectives this work were to characterize kinetics acute respiratory syndrome 2 (SARS-CoV-2) concentration in upper tract (URT) and antibody response patients with (D+) without (D-) dexamethasone treatment.Data biosamples from hospitalized COVID-19, enrolled between 4th March 11th December 2020 a prospective observational study, analysed....
Patients with post-COVID-19 condition frequently suffer from chronic dyspnoea. The causes and mechanism for dyspnoea in these patients without evidence of structural lung disease are unclear.
Neurologic immune-related adverse events (irAE-n) are rare but severe toxicities of immune checkpoint inhibitor (ICI) treatment. To overcome diagnostic and therapeutic challenges, a better mechanistic understanding irAE-n is paramount.
Abstract Background The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of and long-term morbidity mortality worldwide despite global efforts in containment, prophylaxis, therapy. With unprecedented speed, the scientific community has generated pivotal insights into pathogen host response evoked by infection. However, deeper characterization pathophysiology pathology remains priority to reduce coronavirus disease 2019 (COVID-19). Methods NAPKON-HAP...
Background Patients with post COVID-19 condition frequently suffer from chronic dyspnoea. The causes and mechanism for dyspnoea in these patients without evidence of structural lung disease are unclear.
Abstract Background Prospective and longitudinal data on pulmonary injury over one year after acute coronavirus disease 2019 (COVID-19) are sparse. Research question With this study, we aim to investigate outcome following SARS-CoV-2 infection including function, computed chest tomography, respiratory symptoms quality of life 12 months. Study design Methods 180 patients COVID-19 were enrolled into a single-centre, prospective observational study examined 6 weeks, 3, months onset symptoms....
Background: In face of the global spread Corona Virus Disease (COVID)-19, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, rationale high positive end-expiratory pressure (PEEP) and prone positioning early ARDS has been questioned. Methods: The first 15 consecutive patients with respiratory failure transferred to a single ICU were assessed over days ventilation. Best PEEP was defined by maximal...