Laure Bosquillon de Jarcy
A5073744066- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Poxvirus research and outbreaks
- Inflammation biomarkers and pathways
- Bacteriophages and microbial interactions
- Obstructive Sleep Apnea Research
- Immune Cell Function and Interaction
- Sepsis Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Connective tissue disorders research
- interferon and immune responses
- Abdominal Surgery and Complications
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
Charité - Universitätsmedizin Berlin
2017-2023
Freie Universität Berlin
2020-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022
Humboldt-Universität zu Berlin
2020-2022
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of disease 139 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts enzyme activities, well untargeted plasma proteomes at 687 sampling points. report an initial spike a systemic inflammatory response, which gradually alleviated followed protein signature indicative tissue repair,...
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such SOFA APACHE II scores show only limited performance for predicting survival severely ill patients. Additional tools also needed monitor treatment, including experimental therapies clinical trials. Comprehensively capturing human physiology, we speculated that proteomics combination with new...
In face of the Coronavirus Disease (COVID)-19 pandemic, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, rationale high positive end-expiratory pressure (PEEP) and prone positioning early ARDS has been questioned.The first 23 consecutive patients with respiratory failure transferred to a single ICU were assessed. Eight excluded: five not invasively ventilated three received veno-venous ECMO support....
Abstract Background Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim this study was estimate the frequency and outcome COVID-19 sequela identify possible risk factors. Methods This observational study, conducted at University Hospital Charité Berlin Unfallkrankenhaus Berlin, Germany, involved hospitalized patients with pneumonia, including 1082 ventilated...
Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical virological disease trajectories. The purpose this work was to identify risk factors associated with need invasive mechanical ventilation (IMV), analyse viral kinetics patients without IMV provide a comprehensive description course.A cohort 168 hospitalised adult COVID-19 enrolled prospective observational study at large European tertiary care...
We designed a multiplex qPCR to differentiate monkeypox virus clades. In evaluations using clinical samples collected in the UK and Nigeria, assay had an overall sensitivity of 78% (95% CI: 67.67% 86.14%) specificity 94% 80.84% 99.30%); for under Ct35 was 98% 91.72% 99.96%) 99.30%).
Dexamethasone has become the standard of care for severe coronavirus disease 2019 (COVID-19), but its virological impact is poorly understood. The objectives this work were to characterize kinetics acute respiratory syndrome 2 (SARS-CoV-2) concentration in upper tract (URT) and antibody response patients with (D+) without (D-) dexamethasone treatment.Data biosamples from hospitalized COVID-19, enrolled between 4th March 11th December 2020 a prospective observational study, analysed....
Abstract COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. There an urgent need for predictive markers that can guide decision-making, inform about the effect of experimental therapies, point novel therapeutic targets. Here, we characterize time-dependent progression through different stages disease, by measuring 86 accredited diagnostic parameters plasma proteomes at 687 sampling points, a cohort 139 patients...
Abstract Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP , displays broad antiviral activity. It reduces HIV-1 infectivity interfering with Env maturation and virion incorporation, increases survival of Influenza A virus-infected mice via innate immune signaling. Its potential in SARS-CoV-2 infection remains largely unknown. Here, we analyzed expression 90K/ 44 hospitalized COVID-19 patients at multiple levels. We quantified 90K protein concentrations serum PBMCs as well...
Abstract Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such SOFA APACHE II scores show only limited performance for predicting survival severely ill patients. Comprehensively capturing host physiology, we speculated that proteomics combination with new data-driven analysis strategies could produce generation prognostic discriminators. We studied...
MPOX virus (MPXV), formerly known as monkeypox virus, led to a rapidly evolving pandemic starting May 2022, with over 90,000 cases reported beyond the African continent. This outbreak was driven by MPXV variant Clade IIb. In addition, I viruses circulating in Democratic Republic of Congo (DRC) are drawing increased attention constantly rise and Ib, first identified 2023, is now co-circulating Ia seems exhibit enhanced human-to-human transmissibility. While most infected individuals display...
Abstract Cell-intrinsic responses mounted in vivo PBMCs during mild and severe COVID-19 differ quantitatively qualitatively. Whether they are triggered by signals emitted productively infected cells of the respiratory tract or are, at least partially, resulting from physical interaction with virus particles, remains unclear. Here, we analyzed susceptibility expression profiles healthy donors upon ex exposure to SARS-CoV SARS-CoV-2. In line absence detectable ACE2 receptor expression, human...
Abstract Background Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical virological disease trajectories. Methods A cohort 168 hospitalized adult COVID-19 patients enrolled a prospective observational study at large European tertiary care center was analyzed. Results Forty-four percent (71/161) required invasive mechanical ventilation (IMV). Shorter duration symptoms before admission (aOR 1.22 per...
Background: In face of the global spread Corona Virus Disease (COVID)-19, best practice for mechanical ventilation in COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) is intensely debated. Specifically, rationale high positive end-expiratory pressure (PEEP) and prone positioning early ARDS has been questioned. Methods: The first 15 consecutive patients with respiratory failure transferred to a single ICU were assessed over days ventilation. Best PEEP was defined by maximal...
Abstract Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP , displays broad antiviral activity. It reduces HIV-1 infectivity interfering with Env maturation and virion incorporation, increases survival of Influenza A virus-infected mice via innate immune signaling. Here, we analyzed expression 90K/ in 44 hospitalized COVID-19 patients. 90K protein serum levels were significantly elevated patients compared to uninfected sex- age-matched controls. Furthermore,...