Belén Millet Pascual-Leone
A5028102548- Long-Term Effects of COVID-19
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Tryptophan and brain disorders
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Amoebic Infections and Treatments
- Parasitic infections in humans and animals
- Liver Diseases and Immunity
- Congenital Anomalies and Fetal Surgery
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
Charité - Universitätsmedizin Berlin
2022-2024
Freie Universität Berlin
2022-2024
Humboldt-Universität zu Berlin
2022-2024
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action unknown, and many patients deteriorate or die despite timely initiation. Here, we identify dexamethasone treatment-induced cellular molecular changes associated with improved survival in COVID-19 patients. We observed reversal transcriptional hallmark signatures monocytes the induction monocyte substate characterized by expression glucocorticoid-response genes. These responses to were detected...
Abstract Background Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim this study was estimate the frequency and outcome COVID-19 sequela identify possible risk factors. Methods This observational study, conducted at University Hospital Charité Berlin Unfallkrankenhaus Berlin, Germany, involved hospitalized patients with pneumonia, including 1082 ventilated...
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression inflammatory responses associate with alterations in microbiome metabolome, we analyzed metagenome, cytokine, transcriptome profiles repeated samples from hospitalized patients uninfected controls, leveraged information post-hoc confounder analysis. Severe was associated a depletion beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance mainly...
Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical virological disease trajectories. The purpose this work was to identify risk factors associated with need invasive mechanical ventilation (IMV), analyse viral kinetics patients without IMV provide a comprehensive description course.A cohort 168 hospitalised adult COVID-19 enrolled prospective observational study at large European tertiary care...
Dexamethasone has become the standard of care for severe coronavirus disease 2019 (COVID-19), but its virological impact is poorly understood. The objectives this work were to characterize kinetics acute respiratory syndrome 2 (SARS-CoV-2) concentration in upper tract (URT) and antibody response patients with (D+) without (D-) dexamethasone treatment.Data biosamples from hospitalized COVID-19, enrolled between 4th March 11th December 2020 a prospective observational study, analysed....
Abstract Cystic echinococcosis (CE) is a worldwide helminthic zoonosis causing serious disease in humans. The WHO Informal Working Group on Echinococcosis recommends stage-specific treatment approach of hepatic CE that facilitates the decision what therapy option most appropriate. Percutaneous aspiration, instillation scolicide, e.g., ethanol or hypertonic saline, and subsequent re-aspiration (PAIR) have been advocated for treating medium-size unilocular WHO-stage CE1 cysts. PAIR can pose...
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy a major risk factor for HAP, the underlying mechanism remains incompletely understood. Here, we demonstrate that antibiotic in hospitalized patients decreased diversity of gut microbiome depletion short-chain fatty acid (SCFA) producers. Mice transplanted patient microbiota reveal these antibiotic-induced...
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression inflammatory responses associate with alterations in microbiome metabolome, we analyzed metagenome, cytokine, transcriptome profiles repeated samples from hospitalized patients uninfected controls, leveraged information post-hoc confounder analysis. Severe was associated a depletion beneficial intestinal microbes, whereas oropharyngeal microbiota disturbance mainly...
Abstract The clinical course of the 2019 coronavirus disease (COVID-19) is variable and to a substantial degree still unpredictable, especially in persons who have neither been vaccinated nor recovered from previous infection. We hypothesized that progression inflammatory responses were associated with alterations microbiome metabolome. To test this, we integrated metagenome, metabolome, cytokine, transcriptome profiles longitudinally collected samples hospitalized COVID-19 patients at...