Miriam Herbert
A5090873604- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Zebrafish Biomedical Research Applications
- Invertebrate Immune Response Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Physiological and biochemical adaptations
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Genetics and Physical Performance
- HIV-related health complications and treatments
- Inflammation biomarkers and pathways
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
Max Planck Institute for Infection Biology
2021-2024
Humboldt-Universität zu Berlin
2024
German Center for Neurodegenerative Diseases
2023
University of Bonn
2020-2021
Charité - Universitätsmedizin Berlin
2021
Medizinische Hochschule Hannover
2020
University Hospital Bonn
2019
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
Abstract ‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract in the majority of patients. A subset patients, however, progresses severe disease and failure with acute distress syndrome (ARDS). Severe COVID-19 has been associated increased neutrophil counts dysregulated immune responses. The mechanisms protective immunity forms pathogenesis inflammation courses remain largely unclear. Here,...
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility omics technologies for application larger cohorts, we compared multiple data layers. Methods Bulk and single-cell transcriptomics, flow cytometry, proteomics, chromatin landscape analysis ATAC-seq as well ex vivo drug stimulation were performed in a small number blood samples derived from...
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in calls for better characterization understanding changes system. Here, we profiled whole blood transcriptomes 39 10 control donors enabling data-driven stratification based molecular phenotype....
Abstract Eosinophils control many aspects of the vertebrate innate immune response. They contribute to homeostasis, inflammatory conditions and defense against pathogens, yet, their function in disease often remains enigmatic. The zebrafish has emerged as a useful model organism for human diseases but tools study eosinophils this are severely limited. Here, we characterize new highly specific marker report transgenic reporter line visualize vivo . In addition, created polyclonal antibody...
Abstract Eosinophils control many aspects of the vertebrate innate immune response. They contribute to homeostasis, inflammatory conditions and defense against pathogens. With varied functions eosinophils, they have been found play both protective pathogenic roles in diseases. The zebrafish (Danio rerio) has emerged as a useful model organism for human diseases but tools study eosinophils this are severely limited. Here, we characterize new highly specific marker gene, embp, report...