Ioanna D. Gemünd
A5047255670- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Complement system in diseases
- Immune Cell Function and Interaction
University of Bonn
2020-2023
Peter Doherty Institute
2021-2023
The University of Melbourne
2021-2023
German Center for Neurodegenerative Diseases
2022-2023
Epigenomics (Germany)
2021
Charité - Universitätsmedizin Berlin
2021
Life & Brain (Germany)
2019
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, it remains unclear whether T cells contribute disease pathology. Here, we combined single-cell transcriptomics proteomics with mechanistic studies assess pathogenic cell functions inducing signals. We identified highly activated CD16
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in calls for better characterization understanding changes system. Here, we profiled whole blood transcriptomes 39 10 control donors enabling data-driven stratification based molecular phenotype....
Population-scale datasets of healthy individuals capture genetic and environmental factors influencing gene expression. The expression variance a interest (GOI) can be exploited to set up quasi loss- or gain-of-function "
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, it remains unclear if T cells contribute disease pathology. Here, we combined single-cell transcriptomics proteomics with mechanistic studies assessing pathogenic cell functions inducing signals. We identified activated, CD16+ increased cytotoxic in severe COVID-19. CD16 expression enabled complex-mediated, receptor-independent degranulation cytotoxicity not found other diseases. from...
Summary Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, it remains unclear if T cells also contribute disease pathology. Here, we combined single-cell transcriptomics proteomics with mechanistic studies assess pathogenic cell functions inducing signals. We identified highly activated, CD16 + increased cytotoxic in severe COVID-19. expression enabled complex-mediated, receptor-independent degranulation cytotoxicity not found other diseases....