A5086420670- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
Technical University of Munich
2021-2025
Institute of Immunology
2024
Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we characterize the dynamics of anti-viral during long-term follow-up and BNT162b2 mRNA-vaccination in convalescents asymptomatic or mild Virus-specific virus-neutralizing antibody titers rapidly declined 9 months infection, whereas virus-specific cytokine-producing polyfunctional T cells persisted, among which IL-2-producing correlated with titers. Among convalescents, 5% individuals failed to mount...
Abstract Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide 1,2 , in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes 3–7 . Here we demonstrate that a liver immune rheostat renders refractory to activation leads loss of effector functions. In preclinical models persistent with hepatotropic viruses such as HBV, dysfunctional CXCR6 + accumulated the and, characteristic hallmark,...
Chronic hepatitis B is characterised by a scarcity and dysfunction of virus-specific CD8 T-cells in the liver. Immunotherapies, such as therapeutic vaccination, thus aim to reinvigorate expand intra-hepatic T-cell immunity control viral infection. Given paucity liver biopsies, we sought identify markers on circulating that reflect immune response at site infection could be used for monitoring therapies. Using pre-clinical models adenoviral hepatocyte-specific delivery HBV genomes, studied...
Persistent HBV infections exhibit limited antiviral CD8 T cell responses characterized by a scarcity of virus-specific cells with reduced effector functions. We recently identified liver tissue-rheostat that curbs function via adenylyl cyclase/cAMP/protein kinase A (PKA) axis. Thus, we aimed to examine the local regulation hepatic cell-mediated on immunity.
Abstract Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is controlled by host´s immune response1-4, but longitudinal follow-up studies of virus-specific immunity to evaluate protection from re-infection are lacking. Here, we report results a prospective study that started during first wave COVID-19 pandemic in spring 2020, where identified 91 convalescents mild SARS-CoV-2 infection among 4554 health care workers. We followed dynamics and magnitude...
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, understanding individual disease courses SARS-CoV-2 immune responses in these is the utmost importance. For more than two years, we followed an immunocompromised with a infection that was eventually cleared absence humoral neutralizing antibody response. By conducting in-depth examination this individual's response comparing it to large cohort convalescents who spontaneously infection, shed light...