A5063219305- Mast cells and histamine
- Herpesvirus Infections and Treatments
- Alzheimer's disease research and treatments
- Social Sciences and Governance
- Systemic Lupus Erythematosus Research
- Plant Taxonomy and Phylogenetics
- Mediterranean and Iberian flora and fauna
- COVID-19 and Mental Health
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Geological and Tectonic Studies in Latin America
- Immune Cell Function and Interaction
- Accounting and Organizational Management
- Diabetes and associated disorders
- Acne and Rosacea Treatments and Effects
- PI3K/AKT/mTOR signaling in cancer
- Banking stability, regulation, efficiency
- Plant and soil sciences
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Soil Geostatistics and Mapping
- Botany, Ecology, and Taxonomy Studies
- Noncommutative and Quantum Gravity Theories
- European history and politics
- Spanish Linguistics and Language Studies
Kindai University
2019-2025
Yale Cancer Center
2024
Yale University
2024
Instituto Venezolano de Investigaciones Científicas
2024
University Hospital Heidelberg
2020-2023
Heidelberg University
2020-2023
Universidad Hispanoamerica
2022
Virginia Commonwealth University
2002-2016
Austral University of Chile
1989-2014
Instituto Nacional de Salud del Niño
2011-2014
Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting human gut, little is known antiviral programs triggered in this organ. To address gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation enterocytes as prime target and, interestingly, found lack positive correlation between susceptibility infection and expression ACE2. Infected...
Abstract Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide 1,2 , in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes 3–7 . Here we demonstrate that a liver immune rheostat renders refractory to activation leads loss of effector functions. In preclinical models persistent with hepatotropic viruses such as HBV, dysfunctional CXCR6 + accumulated the and, characteristic hallmark,...
Interleukin-3 (IL-3) and stem cell factor (SCF) are important mast growth differentiation factors. Since both cytokines activate the transcription signal transducer activator of 5 (Stat5), a known regulator proliferation survival, we investigated effects Stat5 deficiency on development survival. Bone marrow-derived (BMMC) populations cultured from Stat5A/B-deficient mice survived in IL-3 + SCF, but not either cytokine alone. These cells demonstrated reduced expression Bcl-2, Bcl-x(L), cyclin...
Herpes simplex virus type 1 (HSV-1) is neurotropic and enters a latent state lasting the lifetime of host. This pathogen has recently been proposed as risk factor for Alzheimer's disease (AD) in conjunction with apolipoprotein E4 (ApoE4). In murine acute infection model, we showed that viral neuroinvasiveness depends directly on overall ApoE dosage especially presence isoform ApoE4. If an interaction between HSV-1 involved AD, it may occur during latency rather than infection. Certainly,...
Abstract Mast cell activation through the high affinity IgE receptor (FcεRI) is a critical component of atopic inflammation. The cytokine TGF-β1 has been shown to inhibit IgE-dependent mast activation, possibly serving dampen cell-mediated inflammatory responses. We present proof that inhibits FcεRI expression reversible pathway diminishes protein, but not mRNA, subunit proteins α, β, and γ. stability expressed assembled surface complex was unaltered by treatment. However, decreased rate...
Statins have recently been shown to act as protectants against several neuropathological conditions. They received special attention in the field of Alzheimer's disease (AD), where epidemiological studies indicating a lower prevalence AD/dementia statin-prescribed populations. Excitotoxicity, which derives from overstimulation glutamate receptors, is major cause neuron death neurological diseases, including AD and epilepsy. We carried out comparative study investigate effects all...
Exhausted T cells with limited effector function are enriched in chronic hepatitis B and C virus (HBV HCV) infection. Metabolic regulation contributes to exhaustion, but it remains unclear how metabolism relates different exhaustion states, is impacted by antiviral therapy, if metabolic checkpoints regulate dysfunction.Metabolic state, transcriptome of virus-specific CD8+ from HBV-infected (n=31) HCV-infected patients (n=52) were determined ex vivo during direct-acting (DAA) therapy. flux...
Hepatitis E virus (HEV) is a significant human pathogen causing both acute and chronic infections worldwide. The cell-intrinsic antiviral response serves as the initial defense against viruses has been shown to be activated upon HEV infection. can replicate in presence of this response, but underlying mechanisms remain poorly understood. Here, we investigated role structural proteins ORF2 ORF3 immunocompetent cells. Mechanistically, found that ectopic ORF2, not ORF3, interfered with...
Apolipoprotein E (ApoE) plays a relevant role in herpes simplex type 1 (HSV-1) infection of the CNS; after by hematogenous route, viral neuroinvasiveness directly depends on APOE gene dose. To analyze effect ApoE isoforms HSV-1 infectivity to brain, we have used model mice humanized for ApoE3 or ApoE4 alleles, and analyzed presence DNA several organs real time quantitative PCR. We found that animals expressing human present very high levels virus brain when compared those allele; contrast,...
Background: Evidence that periodontal disease is a possible risk factor for cognitive impairment may be explained by the inflammatory hypothesis. The aim of this study to determine whether periodontitis related amyloid β (Aβ) load in blood and role any such relationship association between Aβ impairment. Methods: A case‐control was performed elderly people diagnosed with or without dementia (cases group) cognitively healthy (control group); data were collected on medical dental history...
Abstract FcεRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits function. In current study show IL-10 has similar regulatory properties, it augments inhibitory effects IL-4. down-regulation was functionally significant, as diminished inflammatory production IgE-mediated up-regulation. reduced β protein without altering α or γ subunits. The ability to alter by...
Apolipoprotein E (ApoE), a constituent of the lipoproteins, may be relevant in herpes simplex virus type 1 (HSV-1) infection central nervous system (CNS), since HSV-1 binds to human serum ApoE lipoproteins. This study demonstrates involvement hematogenous route CNS.
The vp7 genes of 194 strains group A rotaviruses representing all known G types were analyzed with three restriction enzymes by direct digestion amplified cDNA copies or deduction the patterns from sequences. Mammalian rotavirus classified into 28 consisting combinations 6 profiles (s1 to s6) obtained Sau96I endonuclease, 9 (h1 h9) HaeIII, and 15 (b1 b15) BstYI. Digestion HaeIII identified sites common all, almost studied, whereas BstYI was most discriminating among strains. clear...
The possibility of noncommutative topological gravity arising in the same manner as Yang-Mills theory is explored. We use Seiberg-Witten map to construct such a based on $SL(2,\mathbf{C})$ complex connection, from which Euler characteristic and signature invariant are obtained. Finally, we speculate description gravitational instantons, well local anomalies.
ABSTRACT Herpes simplex virus type 1 (HSV-1) causes disease in humans and animals. Infection usually occurs via the neural route possibly hematogenous route. The latter, however, is main by which immunosuppressed individuals neonates are infected. Gender-dependent differences incidence severity of some viral infections have been reported. To detect between sexes with respect to HSV-1 colonization disease, characteristics both acute latent hematogenously infected male female mice were...
Recent clinical findings support the notion that progressive deterioration of cholesterol homeostasis is a central player in Alzheimer's disease (AD). Epidemiological studies suggest high midlife plasma total levels are associated with an increased risk AD. This paper reports concentrations, cognitive performance, locomotor activity and neuropathological signs murine model (transgenic mice expressing apoB100 but knockout for LDL receptor [LDLR]) human familial hypercholesterolaemia (FH)....
Using a large sample of U.S. mortgages observed over the 2005-2009 period, we find that foreclosures are contagious. After controlling for major factors known to influence borrower's decision default, including borrower and loan characteristics, local demographic economic conditions, changes in property values, likelihood mortgage default increases by as much 24% with one standard deviation increase foreclosure rate surrounding zip code. We contagion is most prevalent among strategic...
This work describes a novel mechanism of neuroprotection by simvastatin: the modulation seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies human neuronal cells showed seladin-1 production to be increased do
Hydraulic conductivity in the saturated phase was determined order to diagnose structural characteristics of Hapludand and Palehumult submitted different management located a series volcanic soils with varied pedological development. Spatial variation hydraulic increases more structured soils. It's magnitude depends on amount coarse porosity.Managements that decrease coares pores reduce capacity conduce water.The sites where experiments big changes after aprolonged flow also show low...