A5031890624- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Probiotics and Fermented Foods
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- Infant Nutrition and Health
- CRISPR and Genetic Engineering
- Fatty Acid Research and Health
- Hepatitis B Virus Studies
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Animal Disease Management and Epidemiology
- Evolution and Genetic Dynamics
- Eicosanoids and Hypertension Pharmacology
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Virology and Viral Diseases
- Digestive system and related health
- Lipoproteins and Cardiovascular Health
- Natural product bioactivities and synthesis
- Machine Learning in Bioinformatics
- Diet, Metabolism, and Disease
- Microbial Metabolites in Food Biotechnology
University of Cologne
2009-2020
University Hospital Cologne
2019-2020
Universidad Nacional de Colombia
2019
Neuron BioPharma (Spain)
2010-2018
German Center for Infection Research
2015-2018
Institute of Virology of the Slovak Academy of Sciences
2011-2015
Seno Medical (United States)
2013
Cornell University
2013
Newbiotechnic (Spain)
2006-2009
Center of Advanced European Studies and Research
2009
Quercetin is a common antioxidant flavonoid found in vegetables, which usually present glycosylated forms, such as quercitrin (3-rhamnosylquercetin). Previous vitro experiments have shown that quercetin exerts bigger effect than the down-regulation of inflammatory response. However, results not been reproduced vivo experimental models intestinal inflammation, did show beneficial effects while its glycosides, or rutin, demonstrated their effectiveness. In this study, we reported model rat...
There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer's disease. The mechanisms for neuroprotection are only partially understood, however, and pleiot
Passage of foot-and-mouth disease virus (FMDV) in cell culture the presence mutagenic base analog 5-fluorouracil or 5-azacytidine resulted decreases infectivity and occasional extinction virus. Low viral loads low fitness enhanced frequency events; this finding was shown with a number closely related FMDV clones populations differing by up to 10(6)-fold relative infections involving either single multiple passages absence chemical mutagens. The treatments increases 2- 6.4-fold mutation...
The ability of two different Lactobacillus strains (Lactobacillus salivarius CECT5713 and fermentum CECT5716), isolated from human breast milk, to modulate the immune response was examined.In rodent bone-marrow-derived macrophages (BMDM), presence Lact. CECT5716 induced pro-inflammatory cytokines, in contrast activation IL-10 by CECT5713. Although both reduced lipopolysaccharide (LPS)-induced inflammatory BMDM, effect more efficient, probably because production higher amounts cytokine. In...
The intestinal anti-inflammatory effects of two probiotics isolated from breast milk, Lactobacillus reuteri and L. fermentum, were evaluated compared in the trinitrobenzenesulfonic acid (TNBS) model rat colitis. Colitis was induced rats by intracolonic administration 10 mg TNBS dissolved 50% ethanol (0.25 ml). Either or fermentum daily administered orally (5 x 10(8) colony-forming units suspended 0.5 ml skimmed milk) to each group (n 10) for 3 weeks, starting 2 weeks before colitis...
The face of hepatitis C virus (HCV) therapy is changing dramatically. Direct-acting antiviral agents (DAAs) specifically targeting HCV proteins have been developed and entered clinical practice in 2011. However, despite high sustained viral response (SVR) rates more than 90%, a fraction patients do not eliminate the these cases treatment failure has associated with selection drug resistance mutations (RAMs). RAMs may be prevalent prior to start treatment, or can selected under therapy,...
ABSTRACT The effect of combinations the mutagenic base analog 5-fluorouracil (FU) and antiviral inhibitors guanidine hydrochloride (G) heparin (H) on infectivity foot-and-mouth disease virus (FMDV) in cell culture has been investigated. Related FMDV clones differing up to 10 6 -fold relative fitness BHK-21 cells have compared. Systematic extinction intermediate was attained with a combination FU G but not mutagen or inhibitor alone. high-fitness required FU, G, H. showing high decreased...
Studies with several RNA viruses have shown that enhanced mutagenesis resulted in decreases of infectivity or virus extinction, as predicted from entry into error catastrophe. Here we report lymphocytic choriomeningitis virus, the prototype arenavirus, is extremely susceptible to extinction by base analog 5-fluorouracil. Virus elimination was preceded increases complexity mutant spectra treated populations. However, careful molecular comparison genomic segments suggests largest mutation...
MS-based quantitative proteomics plays an increasingly important role in biological and medical research the development of these techniques remains one most challenges mass spectrometry. Numerous stable isotope labeling approaches have been proposed. However, particularly case 18O-labeling, a standard protocol general applicability is still lacking, statistical issues associated to methods remain be investigated. In this work we present improved high-throughput method based on whole...
HCV affects 185 million people worldwide and leads to death morbidities. has a high genetic diversity is classified into seven genotypes 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance cure rates depend on geno/subtype (GT).Analysis of epidemiological information viral GT from patients undergoing genotyping in 2011-2015.Anonymized 52 centers was analyzed retrospectively.37,839 samples were included the study. We show that distribution similar throughout...
ObjectivesWe investigated the prevalence of raltegravir resistance-associated mutations at baseline and their evolution during therapy in patients infected with different HIV-1 subtypes.
The increase in the prevalence of allergic diseases children has been attributed to an unbalanced immune response probably due environmental factors. immunoregulatory properties probiotic bacteria could balance disequilibrium causing response. aim this study was evaluate immunological effects consumption a dairy product containing two strains suffering from allergy. A double-blinded, randomized, control comparative performed with 44 children. Children were randomly distributed groups, Yogurt...