A5003426085- Hepatitis C virus research
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Hepatitis Viruses Studies and Epidemiology
- Microscopic Colitis
- Diet and metabolism studies
- Liver Diseases and Immunity
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Microbial Metabolites in Food Biotechnology
- Phytoestrogen effects and research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Vascular Malformations and Hemangiomas
- Gastrointestinal Tumor Research and Treatment
Central University Hospital of Asturias
2016-2025
Instituto de Investigación Sanitaria del Principado de Asturias
2018-2025
Hospital de Basurto
2024
Gobierno de Chile
2024
Gobierno del Principado de Asturias
2020
Hospital Clínico San Carlos
1985-2017
Hospital Universitario De Cabueñes
2002-2016
Rafael Advanced Defense Systems (Israel)
2014
Seno Medical (United States)
2009
University Gastroenterology
2009
The role of computer-aided detection in identifying advanced colorectal neoplasia is unknown.To evaluate the contribution to colonoscopic neoplasias as well adenomas, serrated polyps, and nonpolypoid right-sided lesions.Multicenter, parallel, randomized controlled trial. (ClinicalTrials.gov: NCT04673136).Spanish cancer screening program.3213 persons with a positive fecal immunochemical test.Enrollees were randomly assigned colonoscopy or without detection.Advanced was defined adenoma and/or...
Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses.
HCV affects 185 million people worldwide and leads to death morbidities. has a high genetic diversity is classified into seven genotypes 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance cure rates depend on geno/subtype (GT).Analysis of epidemiological information viral GT from patients undergoing genotyping in 2011-2015.Anonymized 52 centers was analyzed retrospectively.37,839 samples were included the study. We show that distribution similar throughout...
The knowledge regarding the intestinal microbial types involved in isoflavone bioavailabililty and metabolism is still limited. present work reports influence of a treatment with isoflavones for six months on faecal bacterial communities 16 menopausal women, as determined by culturing culture-independent techniques. Changes were analysed respect to women's equol-producing phenotype. Compared baseline, at 1 3 counts all populations faeces women had increased strongly. In contrast, among...
The characterization of the humoral response in cancer patients is becoming a practical alternative to improve early detection. We prepared phage microarrays containing colorectal cDNA libraries identify phage-expressed peptides recognized by tumor-specific autoantibodies from patient sera. From total 1536 printed phages, 128 gave statistically significant values discriminate control samples. this, 43 peptide sequences were unique following DNA sequencing. Six phages homologous STK4/MST1,...
Abstract Background Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of disease continues be unacceptable in many settings. Objective To analyze impact improved knowledge provided by successive international on reducing improving process European patients with EoE. Methods Cross‐sectional analysis EoE CONNECT registry based practice. Time periods defined publication dates four major sets over 10 years were...
Abstract Background Inflammatory bowel disease (IBD) and psoriatic arthritis (PsA) are immune-mediated diseases (IMDs) that have been independently related to shifts in the gut microbiota. In this pilot study, we analyzed whether, patients whom both IMIDs coexist, composition function of microbiota is different from when only one two IMDs exists. Methods Transversal observational study performed at a Spanish tertiary hospital. Ten with concomitant IBD PsA (group A) were included. Two age,...
Abstract Background The prevalence of older adults with inflammatory bowel diseases (IBD) is increasing. European Crohn's and Colitis Organization recommends that frailty should be considered in management decision-making elderly IBD patients rather than just chronological age. However, there no “gold standard” tool for the assessment IBD. aim this study to assess using 4 scales evaluate agreement between them. Methods Astur-Frailty-IBD study, a multicentre prospective attended at three...
Little is known about the impact of Epstein-Barr virus (EBV) infection on clinical outcomes in adults with inflammatory bowel disease (IBD).To evaluate seroprevalence, seroconversion rate and complications associated EBV an adult IBD cohort attending a tertiary care hospital Spain between 2006 2016.EBV serological status was determined. In seronegative patients, evaluated. The primary latent are described.One thousand four hundred eighty-three patients over age 17 were included study (mean...
Humoral response in cancer patients can be used for early detection. By screening high‐density protein microarrays with sera from colorectal (CRC) and controls, we identified 16 tumor‐associated antigens (TAAs) exhibiting high diagnostic value. This number of TAAs requires the development multiplex assays combining different a faster more accurate prediction CRC. Here, have developed optimized bead‐based assay using nine selected two controls to provide test CRC diagnosis. We screened...
The gut microbiota remains relatively stable during adulthood; however, certain intrinsic and environmental factors can lead to dysbiosis. Its restoration towards a healthy condition using best-suited prebiotics requires previous development of in vitro models for evaluating their functionality. Herein, we carried out fecal cultures with from normal-weight morbid obese adults. Cultures were supplemented different inulin-type fructans (1-kestose, Actilight, P95, Synergy1 Inulin)...
The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management identifying mechanisms for disease onset progression are required. However, the paucity large patient cohorts heterogeneity practice hinder defining optimal EoE.EoE CONNECT is an ongoing, prospective registry study initiated in 2016 currently managed by EUREOS, European Consortium Eosinophilic Diseases Gastrointestinal Tract....
Abstract Introduction The risk of colon cancer is greater in patients with inflammatory bowel disease (IBD) than the general population. Chromoendoscopy dye (CE) currently recommended method for detecting dysplasia screening colonoscopies IBD patients; however, role virtual chromoendoscopy (VC) not yet well defined. Objective object this study was to compare CE and VC iSCAN 1 system detection neoplastic lesions patients. Design We conducted a prospective, single-center, randomized who...
Summary We report the largest study on prevalence and distribution of HCV genotypes in Spain (2000‐2015), we relate them with clinical, epidemiological virological factors. Patients from 29 hospitals 10 autonomous communities (Andalusia, Aragon, Castilla‐Leon, Catalonia, Galicia, Canary Islands, Madrid Community, Valencian Murcia Region Basque Country) have been studied. Annual subtypes, as well gender, age, transmission route, HIV and/or HBV coinfection, treatment details were recorded....