A5004751628- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Microbial Metabolism and Applications
- Complementary and Alternative Medicine Studies
- Microscopic Colitis
- Cancer Cells and Metastasis
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Image Retrieval and Classification Techniques
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Fungal Biology and Applications
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2021-2025
Complejo Hospitalario de Ourense
2022-2024
Complexo Hospitalario Universitario A Coruña
2022-2024
Fundación Pública Galega de Medicina Xenómica
2024
The role of computer-aided detection in identifying advanced colorectal neoplasia is unknown.To evaluate the contribution to colonoscopic neoplasias as well adenomas, serrated polyps, and nonpolypoid right-sided lesions.Multicenter, parallel, randomized controlled trial. (ClinicalTrials.gov: NCT04673136).Spanish cancer screening program.3213 persons with a positive fecal immunochemical test.Enrollees were randomly assigned colonoscopy or without detection.Advanced was defined adenoma and/or...
The genomic diversity of circulating tumor cells (CTCs) and its clinical implications remain poorly understood. In this study, we characterized the mutational landscape CTC pools stemming from 29 metastatic colorectal cancer (mCRC) patients examined relationship with disease progression. Our analysis revealed substantial variation in burden among patients, all harboring non-silent mutations key CRC driver genes. Importantly, higher was significantly associated reduced overall survival....
Both vedolizumab and ustekinumab are approved for the management of Crohn's disease [CD]. Data on which one would be most beneficial option when anti-tumour necrosis factor [anti-TNF] agents fail limited.
Background PolyDeep is a computer-aided detection and classification (CADe/x) system trained to detect classify polyps. During colonoscopy, CADe/x systems help endoscopists predict the histology of colonic lesions. Objective To compare diagnostic performance expert for optical diagnosis colorectal polyps on still images. Methods Image Classification (PIC) an in vitro test study. The PIC database contains NBI images 491 with histological diagnosis. We evaluated four neoplasia (adenoma,...
The genomic profiling of circulating tumor cells (CTCs) in the bloodstream should provide clinically relevant information on therapeutic efficacy and help predict cancer survival. Here, we contrasted profiles CTC pools recovered from metastatic colorectal (mCRC) patients using different enrichment strategies (CellSearch, Parsortix, FACS). Mutations inferred differed depending strategy and, all cases, represented a subset mutations detected matched primary samples. However, part, CellSearch,...
Abstract Background Main aim: To evaluate the retention rate of ustekinumab compared to vedolizumab in Crohn’s disease patients who failed anti-TNF therapy clinical practice. Secondary aims: compare short-term and long-term effectiveness, safety both treatments. Methods had received either or after failure intolerance agents from ENEIDA registry were included. is a prospectively maintained database promoted by GETECCU. A total 755 30 centres included at time data extraction. Clinical...
Abstract Background Patients with inflammatory bowel disease (IBD) are often classified as ulcerative colitis (UC) and Crohn’s (CD). However, in some cases this categorization is not possible these patients labelled unclassified (IBDU) -or indeterminate if histologic analysis of surgical specimens possible-.The aims study were to compare the prognosis therapeutic requirements IBDU UC, identify potential predictive factors reclassification UC or CD. Methods Retrospective, observational,...
Most colorectal cancer patients diagnosed are candidates for surgical resection with curative intent, although surgery is associated some complications that could be life-threatening. Antibiotic prophylaxis commonly used the prevention of infectious postoperative complications. However, this intervention can change composition intestinal microbiota and promote adverse inflammatory outcomes in patients. The combination different fungal extracts beneficial because their role gut modulation...
Abstract The genomic profiling of circulating tumor cells (CTCs) in the bloodstream should provide clinically relevant information on therapeutic efficacy and help predict cancer survival. However, molecular characterization CTCs has so far proven extremely difficult. A variety technologies have been developed for CTC isolation, but impact assessment not fully evaluated. To fill this gap, here we contrasted profiles pools recovered from blood samples obtained four metastatic colorectal...
<sec> <title>BACKGROUND</title> Most colorectal cancer patients diagnosed are candidates for surgical resection with curative intent, although surgery is associated some complications that could be life-threatening. Antibiotic prophylaxis commonly used the prevention of infectious postoperative complications. However, this intervention can change composition intestinal microbiota and promote adverse inflammatory outcomes in patients. The combination different fungal extracts beneficial...