A5007283514- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2021-2025
Hospital Universitario Araba
2025
Complejo Hospitalario de Ourense
2004-2024
Complexo Hospitalario Universitario A Coruña
2013-2024
Instituto de Investigación Sanitaria de Santiago
2023-2024
Columbia University
2023-2024
Sociedade Brasileira de Anestesiologia
2020
Presbyterian Hospital
2020
Cornell University
2020
Universitat de Barcelona
2018
We investigated whether increased collagen type I synthesis and deposition contribute to enhancement of myocardial fibrosis deterioration cardiac function in patients with hypertensive heart disease (HHD).We studied 65 hypertensives left ventricular hypertrophy subdivided into 2 groups: 34 without failure (HF) 31 HF. Transvenous endomyocardial biopsies the interventricular septum were performed quantify amount fibrotic tissue extent deposition. The carboxy-terminal propeptide procollagen...
β-Blockers and endoscopic variceal ligation (EVL) have proven to be valuable methods in the prevention of rebleeding. The aim this study was compare efficacy EVL combined with nadolol versus alone as secondary prophylaxis for bleeding. Patients admitted acute bleeding were treated during emergency endoscopy or sclerotherapy received somatostatin 5 days. At that point, patients randomized receive plus alone. sessions repeated every 10 12 days until varices eradicated. Eighty cirrhosis...
Abstract Aim The diagnostic accuracy of the faecal immunochemical test ( FIT ) at a 100 ng/ml threshold for colorectal cancer CRC was compared with N ational I nstitute H ealth and C are E xcellence NICE S cottish ntercollegiate G uidelines etwork SIGN referral criteria. Method A multicentre, prospective, blind study tests carried out in two panish health areas. In 787 symptomatic patients referred colonoscopy, we determined whether met All performed one determination OC sensor ™ )....
Abstract Colorectal cancer is a major health problem, where advances towards computer-aided diagnosis (CAD) systems to assist the endoscopist can be promising path improvement. Here, deep learning model for real-time polyp detection based on pre-trained YOLOv3 (You Only Look Once) architecture and complemented with post-processing step an object-tracking algorithm reduce false positives reported. The base network was fine-tuned using dataset composed of 28,576 images labelled locations 941...
PURPOSE The goal of this work was to perform a comprehensive exploration the relationship between clinical outcome diffuse large B-cell lymphoma (DLBCL) and expression panel tumor suppressor oncogenic proteins, which includes some cell-cycle regulator proteins involved in p53 pathway. PATIENTS AND METHODS To end, we collected data 141 patients with DLBCL immunohistochemically analyzed diagnostic tumoral tissue from each patient for presence Ki67 (MIB1, Immuno-tech, Marseille, France), bcl2,...
Background The thickness of the cortical mantle is a sensitive measure for identifying alterations in structure. We aimed to explore whether first episode schizophrenia patients already show significant thinning and anomalies may significantly influence clinical cognitive features. Method investigated regional changes large heterogeneous sample spectrum ( n =142) at their break illness healthy controls =83). Magnetic resonance imaging brain scans (1.5 T) were obtained images analyzed by...
Resident cardiac macrophages are critical mediators of function. Despite their known importance to electrophysiology and tissue maintenance, there currently no stem-cell-derived models human engineered tissues (hECTs) that include resident macrophages. In this study, we made an induced pluripotent stem cell (iPSC)-derived hECT model with a population (iM0) better recapitulate the native myocardium characterized impact on Macrophage retention within hECTs was confirmed via immunofluorescence...
Background: PolyDeep is a computer-aided detection and characterization system that has demonstrated high diagnostic yield for in vitro of colorectal polyps. Our objective to compare the performance expert endoscopists polyp detection. Methods: Advance 1 (NCT05514301) an unicentric test study with second observer design. Endoscopists performed colonoscopy blinded PolyDeep's results. The main endpoint was sensitivity (adenoma, serrated or hyperplastic lesion) secondary endpoints were...
Bacterial translocation (BT) has been involved in the pathogenesis of spontaneous bacterial peritonitis (SBP) experimental cirrhosis. Because malnutrition is a common feature cirrhosis, aim this study was to evaluate effect nutrition on BT and SBP. We induced cirrhosis 44 Sprague-Dawley rats by administration oral CCl 4 , and, afterward, 26 animals were maintained with dietary restriction. Cultures mesenteric lymph nodes (MLN), peripheral portal blood, liver, spleen performed. SBP occurred...
Background Schizophrenia is a chronic brain disorder associated with structural abnormalities already present at the onset of illness. Whether these might progress over time still under debate. Method The aim this study was to investigate likely progressive volume changes in schizophrenia during first 3 years after initiating antipsychotic treatment. included 109 patients spectrum and control group 76 healthy subjects. Subjects received detailed clinical cognitive assessment magnetic...
Cell cycle progression is regulated by the combined action of cyclins, cyclin-dependent kinases (CDKs), and CDK-inhibitors (CDKi), which are negative cell regulators. p27KIP1 a CDKi key in regulation, whose degradation required for G1/S transition. In spite absence expression proliferating lymphocytes, some aggressive B-cell lymphomas have been reported to show an anomalous staining. We analysed series Diffuse Large Lymphoma (DLBCL), correlating it with proliferative index clinical outcome,...
Background: intestinal bacterial overgrowth (IBO) is related to small bowel motility and has been involved in the pathogenesis of translocation (BT) experimental models, both overgrowing gut flora translocating bacteria mesenteric lymph nodes are common features cirrhosis.Objectives: aims this study were analyze cecal aerobic transit cirrhotic rats, their relationship with BT, evaluating role dismotility development BT cirrhosis.Material methods: we included twenty-seven male Sprague-Dawley...
Gloria Fernandez-Esparrach, Angel Calderon, Joaquin de-la-Pena, Jose B. Diaz-Tasende, Miguel Esteban, Antonio Zebenzuy Gimeno-Garcia, Alberto Herreros-de-Tejada, David Martinez-Ares, Nicolas-Perez, Oscar Nogales, Akiko Ono, Aitor Orive-Calzada, Adolfo Parra-Blanco, Sarbelio Rodriguez-Munoz, Eloy Sanchez-Hernandez, Andres Sanchez-Yague, Enrique Vazquez-Sequeiros, Juan Vila and Leopoldo Lopez-Roses; on behalf of the Sociedad Espanola de Endoscopia Digestiva (SEED)
Background: the Galician Health Service established indications and priority levels (I = fast track, II preferential, III normal) for colonoscopy, according to risk of colorectal cancer significant colonic lesions detection with access from primary health care.Our aim is show results implementation.Methods: we included colonoscopies requested in symptomatic patients June October 2012 a prospective observational cross sectional study.We collected care level (primary, secondary), priority,...
Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise.The objective this study was to assess the efficacy and learning curve gastric ESD with hybrid knife pressure water jet compare standard ESD.We performed prospective non survival animal comparing hybrid-knife ESD. Variables recorded were: Number en-bloc ESD, number all marks included (R0), size specimens, time speed adverse events. Ten endoscopists...
Background PolyDeep is a computer-aided detection and classification (CADe/x) system trained to detect classify polyps. During colonoscopy, CADe/x systems help endoscopists predict the histology of colonic lesions. Objective To compare diagnostic performance expert for optical diagnosis colorectal polyps on still images. Methods Image Classification (PIC) an in vitro test study. The PIC database contains NBI images 491 with histological diagnosis. We evaluated four neoplasia (adenoma,...