Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether supplementation associated with favorable maternal and fetal outcomes. This was a secondary analysis 215 pregnant women who were enrolled our prior study. With data from telephone interviews prenatal supplementation, existing demographic, statistically...

The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. population included a random sample singleton pregnant women in whom we measured total homocysteine folic acid or at deliveries. A 227 were enrolled. concentration folate tended be significantly lower pre-term birth than full-term delivery group (median (95% CI), 14.4 (3.6–73) vs 25 (7.3–105.5) p < 0.01). was higher pre-eclampsia...

Abstract The biotransformation by Flavobacterium sp. of the following organophosphate pesticides was experimentally and theoretically studied: phorate, tetrachlorvinphos, methyl‐parathion, terbufos, trichloronate, ethoprophos, phosphamidon, fenitrothion, dimethoate DEF. ATCC 27551 strain bearing organophosphate‐degradation gene used. Bacteria were incubated in presence each pesticide for a duration 7 days. Parent identified quantified means gas‐chromatography mass spectrum system. Activity...

SummaryThe primary objective of this study was to evaluate in a random double-blind design, the sedative and behavioural responses children undergoing outpatient paediatric dental procedures receiving either chloral hydrate (CH) alone or combination with hydroxyzine. Forty American Society Anaesthesiologists class I (21 36 months age) were randomly allocated receive 70mg/kg CH 2 mglkg The degree crying, movement overall behaviour evaluated during treatment at different times. hydrate/...

BACKGROUND We aimed to investigate the risk factors associated with unintended pregnancies as well association between and potential teratogenic exposures. METHODS A cross-sectional survey was performed among women attending Maternity School of Samsung Cheil Hospital Women's Health Care Center in Seoul, Korea. Demographic data, obstetric history, socioeconomic status, intention become pregnant, exposure teratogens were obtained. RESULTS total 1354 median age 29 years gestational weeks...

Summary Background : We aimed to evaluate the efficacy of clear liquids orally administered at 06:00–06:30 am on morning surgery reduce prolonged preoperative fasting periods. Methods After obtaining informed parental consent, 100 children undergoing scheduled orthopedic surgical procedures, ASA I–II, were randomly allocated two groups. In group 1, underwent typical overnight period and patients in 2 received a commercial brand apple juice (glucose 28 g 250 ml) day surgery. Patients &lt;3...

SUMMARY 1. A study performed &gt; 10 years ago and case reports published recently suggest that triclabendazole is effective for the treatment of patients with fascioliasis. 2. To confirm efficacy a human formulation triclabendazole, we enrolled 165 into present divided subjects two groups: (i) those who had fascioliasis, as evidenced by presence ova in their stools; (ii) clinical laboratory data suggesting 3. Patients were randomly allocated to receive mg/kg, p.o., 1, 2 or 3 days (single‐,...

Oxytocin is extensively used to induce or augment uterine contractions, especially facilitate the third stage of labor in humans.Administration oxytocin parturient sows reduces duration whereas mortality offspring may remain unchanged.This study aimed evaluate whether time administration during parturition alter response and fetal outcomes.Two hundred were randomly assigned intramuscularly receive either saline solution (control group) 0.083 IU/kg immediately after delivery 1 st , 4 th 8...

Objective. A reliable biomarker of low alcohol exposure during pregnancy is needed to clarify the controversy on teratogenicity low-to-moderate levels. Methods. Blood samples were obtained from 13 pregnant women who self-reported ingestion between 2.5 and 20 drinks/week, 26 controls. Total lipids extracted, phosphatidylethanol (PEth) species 16:0/16:0, 16:0/18:1, 16:0/18:1 separated by high-performance liquid chromatography (HPLC) a reverse-phase phenyl column. These PEth quantified MS/MS...

Abstract Aconitum roots are traditionally prescribed for the management of different types painful affections in Asiatic countries. A quantitative structure‐activity relationship (QSAR) analysis was performed to study effect chemical substitutes analgesic potency alkaloids available Chinese roots. Using CAChe program package biomolecules, molecular modelling 12 previously tested a model acetic acid‐induced writhing rats. The ED 50 ( μ mol/kg) used as activity parameter. Structural parameters...

Objective: To assess the fetal outcome of three hypertensive women exposed to amlodipine. 5 mg/day, in first trimester pregnancy. Case 1: The patient was treated with amlodipine until 7 weeks gestation. She also levosulpiride, aluminum hydroxide gel, magnesium carbonate, and Ginkgo biloba. At 38+3 pregnancy, she delivered a 3750 g healthy female baby, restarted taking amlodipine, while exclusively breastfeeding her daughter. months age, infant healthy. 2: from 2+2 3+4 Her treatment modified...

Piglets appear to be neurologically sensitive intrapartum asphyxia. Our aim was investigate the short-term neurophysiologic consequences of asphyxia in piglets. We studied 10 piglets suffering and control Glucose blood gas levels, tympanic membrane temperature, body weight were measured within first 2 min after birth. Animals followed up for a 5-day period. As surrogated markers piglets' neurological function, viability score time elapsed from birth contact with maternal udder recorded. In...

Gastrointestinal irritability can deter pregnant women from starting or continuing prenatal multivitamin supplementation. In a previous study, suboptimal tolerability was observed among taking large tablet (18 mm x 8 mm) with high elemental iron content (60 mg as ferrous fumarate). The objective of the present study to compare rates adherence and reported adverse events who were randomized commence supplementation small-tablet multivitamin, containing either low content.Pregnant called...

Objective. Phosphatidylethanol (PEth) is formed endogenously by the direct action of ethanol, and has a half-life long enough to make it reliable biomarker alcohol exposure in early pregnancy. In this study, we aimed characterize PEth blood concentrations differentiate different levels pregnant women. Methods. The study consisted 305 consecutive women who had been referred our hospital for antenatal care. Of them, 117 self-reported ingestion first trimester pregnancy 188 were abstainers....

Biological activity of Aconitum alkaloids may be related to their toxicity rather than a specific pharmacological action. A Quantitative structure-activity relationships (QSAR) analysis was performed on the following two groups alkaloids: compounds with an aroyl/aroyloxy group at R(14) position (yunaconitine, bulleyaconitine, aconitine, beiwutine, nagarine, 3-acetyl and penduline), aroyloxy R(4) (N-deacetyllappaconitine, lappaconitine, ranaconitine, N-deacetylfinaconitine,...

1. Maria Tetelbaum, MD* 2. Yaron Finkelstein, MD* 3. Alejandro A. Nava-Ocampo, MD* 4. Gideon Koren, MD* 1. *Division of Clinical Pharmacology & Toxicology, Department Pediatrics and Population Health Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada After completing this article, readers should be able to: Recognize age-related changes in pharmacokinetics pharmacodynamics drugs. 2. Describe the dynamics rational drug dosing neonates children. 3. Identify areas...

We aimed to investigate the factors associated with a positive intake of folic acid (FA) during periconceptional period among Korean women.In cross-sectional study demographic, obstetric and socio-economic data, history FA awareness benefits supplementation in pregnancy were obtained analysed using chi2 test, followed by multiple logistic regression analysis.The Maternity School, Cheil General Hospital Women's Healthcare Center, Seoul, South Korea, between October 2005 March 2006.In total...