A5002267516- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Parvovirus B19 Infection Studies
- Congenital Anomalies and Fetal Surgery
- Birth, Development, and Health
- Fetal and Pediatric Neurological Disorders
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Renal and related cancers
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Substance Exposure Effects
- Pregnancy and Medication Impact
- Epigenetics and DNA Methylation
- Preterm Birth and Chorioamnionitis
- Bariatric Surgery and Outcomes
- Maternal and Perinatal Health Interventions
- Advanced Fiber Optic Sensors
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Thin-Film Transistor Technologies
- Magneto-Optical Properties and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition, Health and Food Behavior
- Genomic variations and chromosomal abnormalities
MizMedi Hospital
2019-2024
Dankook University
2015-2019
Cheil General Hospital and Women's Healthcare Center
2010-2019
Wake Forest University
2017
Monash University
2017
Monash Health
2017
Kaiser Permanente
2017
Ambry Genetics (United States)
2017
Tianjin Children's Hospital
2017
Pennington Biomedical Research Center
2017
Two SNPs in melatonin receptor 1B gene, rs10830963 and rs1387153 showed significant associations with fasting plasma glucose levels the risk of Type 2 Diabetes Mellitus (T2DM) previous studies. Since T2DM gestational diabetes mellitus (GDM) share similar characteristics, we suspected that two genetic polymorphisms MTNR1B may be associated GDM, conducted association studies between disease. Furthermore, also examined effects various diabetes-related phenotypes. A total 1,918 subjects (928 GDM...
Background We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria but not Carpenter-Coustan (CC) criteria. Methods A total 8,735 Korean pregnant identified at two hospitals between 2014 2016. Among them, 2,038 participated prospective cohort to investigate outcomes. Diagnosis GDM was made via two-step approach 50-g glucose challenge test for screening...
Postpartum depression (PPD) can negatively affect infant well-being and child development. Although the frequency risk factors of PPD symptoms might vary depending on country culture, there is limited research these among Korean women. This study aimed to elucidate potential throughout pregnancy help improve screening prevention in
Objective. A reliable biomarker of low alcohol exposure during pregnancy is needed to clarify the controversy on teratogenicity low-to-moderate levels. Methods. Blood samples were obtained from 13 pregnant women who self-reported ingestion between 2.5 and 20 drinks/week, 26 controls. Total lipids extracted, phosphatidylethanol (PEth) species 16:0/16:0, 16:0/18:1, 16:0/18:1 separated by high-performance liquid chromatography (HPLC) a reverse-phase phenyl column. These PEth quantified MS/MS...
Background Cell-free fetal DNA and cell-free total in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during pregnancy. However, correlation change spontaneous abortion (SA) with chromosomal aneuploidy not yet reported. Therefore, we investigated levels SA women aneuploidy. Methodology/Principal Findings A nested case-control study was conducted plasma collected from 268 their first trimester Subjects included 41 normal...
To estimate the odds ratio of prepregnant body mass index (BMI), gestational weight gain (GWG), and diabetes mellitus (GDM) for excessive fetal growth, which we define as large age (LGA).We included 16,297 women who delivered a live-born singleton baby at term. We fit logistic regressions to ratios variables, including maternal age, parity, BMI ≥23, GWG ≥15 kg, GDM, LGA. classified into four categories (<10, 10-14.9, 15-19.9, ≥20 kg) (underweight, normal, overweight, obese). After adjusting...
We aimed to investigate the factors associated with a positive intake of folic acid (FA) during periconceptional period among Korean women.In cross-sectional study demographic, obstetric and socio-economic data, history FA awareness benefits supplementation in pregnancy were obtained analysed using chi2 test, followed by multiple logistic regression analysis.The Maternity School, Cheil General Hospital Women's Healthcare Center, Seoul, South Korea, between October 2005 March 2006.In total...
To estimate the association between uterine compression sutures for postpartum hemorrhage and subsequent pregnancy outcomes.We reviewed medical records of 336 women who received to control during their first delivery at a single center 2006 2011. Of these, 42 became pregnant again care through our hospital were included in this study. One hundred thirty-nine matched age parity did not receive previous cesarean served as group. We compared outcomes operative findings repeat two groups.There...
Objective To estimate the distribution of FMR1 alleles and prevalence premutaion (PM) full mutation (FM) gene in Korean women reproductive age. Methods Using polymerase chain reaction Southern blot, 5829 age were screened (low-risk group n = 5470 high-risk 359) 11 prenatal diagnoses completed between September 2003 December 2011. Results Of screened, normal (11,607) had a bimodal with most having 29 (37.87%) 30 (31.87%) CGG repeats. low-risk group, 7 PM identified, giving carrier frequency...
We evaluated the effect on treatment using new International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) diagnosis.Singleton pregnant women whose plasma glucose levels were ≥140 mg/dL 50 g challenge test (GCT) underwent 75 oral tolerance GDM diagnosis. During first half study period, was diagnosed 2 abnormal values by Carpenter-Coustan (C-C) criteria. In second 1 or more IADPSG used Pregnant classified into 5 groups: normal GCT,...
Among the non-invasive screening methods for identification of fetal aneuploidy, NIPT (non-invasive prenatal testing) shows highest sensitivity and specificity in high-risk pregnancies. Due to low false positive rate NIPT, it is assumed that implementation as a primary method may reduce number invasive tests result similar or lowered cost overall detection Down syndrome. However, most previous studies are based on theoretical economic analysis. This study aims determine effectiveness various...
Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from maternal plasma for aneuploidy identification is expanding worldwide. The objective of this study was to evaluate the clinical utility NIPT detection trisomies 21, 18, and 13 high-risk fetus in a large Korean population.
The aim of this study was to develop a simple and effective method for noninvasively detecting fetal sex using circulating DNA from first-trimester maternal plasma. A conducted with plasma collected 203 women between 5 12 wk gestation. presence confirmed by quantitative methylation-specific polymerase chain reaction the unmethylated-PDE9A gene (U-PDE9A). Multiplex real-time PCR used simultaneously quantify amount DYS14 GAPDH in results were phenotype at birth. Pregnancy outcomes U-PDE9A...
To evaluate not only the risk of total preterm birth (PTB) but also spontaneous (sPTB) and indicated (iPTB) in vanishing twin (VT).This is a secondary analysis multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled early pregnancy followed up till delivery.A 4,746 included final analysis, and. frequency VT was 1.1% (54/4746). group had higher for PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 1.6% 13.0%, PTB<28 0.9%...
The purpose of this study is to compare perinatal outcomes twin pregnancies complicated by gestational diabetes (GDM) with those unaffected GDM. A total 1,154 who delivered at Cheil General Hospital, between January 1998 and December 2002 were recruited participate in a retrospective analysis. Out these pregnancies, 37 women had Four exposed GDM excluded due the loss medical records; therefore 33 enrolled. We matched 1:2 ratio; there GDM/66 without during period. Our findings show that no...
This study aimed to assess the pregnancy outcomes of women who reported social intake low or very alcohol levels during pregnancy.Obstetric and foetal were assessed in a prospective cohort 1667 pregnant consumption (cases) 1840 alcohol-abstainer (controls).Among cases, occurred first 4.4 (median) weeks pregnancy, with median ingestion 1.0 (0.01-6.0) drinks/week, equivalent 7.6 (0.09-47.5) g/week. Cigarette smoking was approximately four times more often exposed group than controls (p <...
Abstract Background Epigenetic mechanisms provide an interface between environmental factors and the genome are influential in various diseases. These mechanisms, including DNA methylation, influence regulation of development, differentiation, establishment cellular identity. Here, we performed high-throughput methylome profiling to determine whether differential patterns methylation correlate with Down syndrome (DS). Materials methods We extracted from chorionic villi cells five normal DS...
In 2019, the Korean Society of Maternal-Fetal Medicine developed first clinical practice guidelines for prenatal aneuploidy screening and diagnostic testing.These were by adapting established in other countries that searched systematically, aim to assist decision making healthcare providers providing care be used as a source education communication with pregnant women Korea.This article delineates specifically maternal serum fetal cell-free DNA (cfDNA) screening.A total 19 key questions (12...
This study evaluated the sensitivities and false positive rates of screening test using ultrasonographic measurement thickness nuchal translucency (NT) with different cut-offs for chromosomal aberration in a Korean population. We included 2,570 singleton pregnancies undergoing ultrasound between 11 weeks 14 gestation this study. analyzed NT alone three -2.5 mm, 3.0 95th percentile each crown rump length (CRL). There were 31 aberrations (1.2%) including 12 cases trisomy 21. The numbers that...