A5032614386- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Maternal and fetal healthcare
- Parvovirus B19 Infection Studies
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Congenital Anomalies and Fetal Surgery
- Urological Disorders and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Pediatric Urology and Nephrology Studies
- Cardiovascular Issues in Pregnancy
- Tumors and Oncological Cases
- Neonatal Respiratory Health Research
- Teratomas and Epidermoid Cysts
- Tracheal and airway disorders
- Maternal and Perinatal Health Interventions
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
- Pleural and Pulmonary Diseases
Asan Medical Center
2013-2023
University of Ulsan
2013-2023
Ulsan College
2013-2023
Kwangwoon University
2019
Asan Foundation
2014
University of California, Irvine
2010
Seoul National University Hospital
2003
Seoul National University
2003
CHA University
2002
Current diagnostic criteria have limited clinical value for prediction of preeclampsia and fetal adverse outcomes. The short-term outcome in pregnant women with suspected study Asia (PROGNOSIS Asia) was a prospective, multicenter designed to investigate the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor) ratio predicting outcomes Asian preeclampsia. Seven hundred sixty-four at gestational week 20+0 days (18+0 Japan) 36+6 were enrolled 25 sites Asia. primary...
Human umbilical cord mesenchymal stromal cells (hUC-MSCs) of Wharton's jelly origin undergo adipogenic, osteogenic, and chondrogenic differentiation in vitro. Recent studies have consistently shown their therapeutic potential various human disease models. However, the biological effects major pregnancy complications on cellular properties hUC-MSCs remain to be studied. In this study, we compared basic obtained from gestational diabetes mellitus (GDM) patients (GDM-UC-MSCs) normal pregnant...
Human umbilical cord mesenchymal stem cells (hUC-MSCs), originating in Wharton's jelly, are multipotent that home to damaged tissues and can modulate the immune system. We examined whether administering extracts of MSCs (MSC-Ex) instead could augment beneficial effects MSC therapy by overcoming low homing efficiency systemically administered inflammatory bowel diseases (IBD). Dextran sodium sulfate-induced colitis model was established C57BL/6 mice, MSC-Ex intraperitoneally. reduced colitis,...
Objective: The purpose of this study was to determine whether concentrations C-reactive protein (CRP) in umbilical cord plasma at birth were elevated neonates with sepsis, an inflammatory lesion the (funisitis) or who born mothers microbial invasion amniotic cavity. Methods: Umbilical collected from 313 singleton preterm (20-35 weeks gestation). results fluid culture performed within 5 days birth, occurrence congenital neonatal sepsis and presence funisitis assessed. Amniocentesis 152...
The aim of this study was to determine whether initial shock index (SI) independently associated with the requirement for massive transfusion (MT) in emergency department (ED) patients primary postpartum hemorrhage (PPH). A retrospective cohort ED PPH performed at a university-affiliated, tertiary referral center between January 2004 and May 2012. Patients were classified two groups: MT group (patients who received ≥10 U packed red blood cells within 24 h admission) non-MT <10 U). Variables...
We investigated whether there is a difference in elastographic parameters between pregnancies with and without spontaneous preterm delivery (sPTD) women short cervix (≤ 25 mm), examined the ability of to predict sPTD those women.E-CervixTM (WS80A; Samsung Medison, Seoul, Korea) elastography was used examine cervical strain. Elastographic were compared sPTD. Diagnostic performance ≤ 37 weeks, both alone combination other parameters, that length (CL) using area under receiver operating...
Mesenchymal stem cells derived from Wharton's jelly of the umbilical cord (UC-MSCs) have immunomodulatory properties. The aim this study was to explore whether extracts MSCs (MSC-Ex) could augment low therapeutic efficacy whole in an Aspergillus fumigatus (Af)-induced atopic dermatitis (AD) model. LPS- or TNF-α/IFN-γ-stimulated keratinocytes (HaCaT cells) were treated with MSC-Ex, and Af-induced AD model established BALB/c mice. In HaCaT cells, MSC-Ex treatment significantly reduced...
Objective To evaluate the outcome in a cohort of fetuses with isolated sacrococcygeal teratoma (SCT) relation to need for utero intervention. Methods We retrospectively analyzed prenatally diagnosed SCT between September 2000 and December 2010. Postnatal outcomes were evaluated intervention by reviewing medical records. Results Of 35 during study period, ten lost follow up three had been misdiagnosed as SCT. Among remaining 22 cases, interventions performed eight, including radiofrequency...
The aim is to evaluate perinatal outcomes of fetal pleural effusion after thoracoamniotic shunting.This was a retrospective study 68 singleton pregnancies with massive that underwent shunting between 1999 and 2012 at Asan Medical Center, Seoul, Korea. Through review medical records, we investigated according the presence hydrops identified prognostic factors by stepwise multivariate logistic regression analysis.Of pregnancies, three were lost follow-up two fetuses died in utero. median...
Rhabdomyoma is the most common type of cardiac tumor in fetuses and often associated with tuberous sclerosis complex (TSC) neurologic sequelae. The purpose this study was to investigate neurodevelopmental outcomes fetal rhabdomyoma.We reviewed clinical characteristics 23 cases rhabdomyoma diagnosed prenatally by echocardiography at Asan Medical Center between January 1998 December 2009. We also postnatal results brain magnetic resonance imaging, echocardiography, renal ultrasound examination...
Hysteresis-free and stable operation achieved in top-gate SnO TFTs by inserting an Al 2 O 3 interlayer that protects the surface of metastable channel.
PTEN is a recently identified tumour suppressor inactivated in wide variety of human cancers, including endometrial cancers. Mutation the gene has been reported approximately 50-83% adenocarcinoma. Despite this fact, study expression protein tumours limited. functions as by regulating cell cycle and survival through signal transduction pathway. was considered to have dual-specificity phosphatase activity, but it now known that its principal physiological activity mainly derived from lipid...
Objective To compare the efficacy and safety of atosiban with those ritodrine in preterm labour. Design Multicentre, single‐blind, randomised, controlled trial. Setting Obstetric units six referral centres Korea. Population Women singleton pregnancies labour, between 24 33 + 6 weeks gestation. Methods One hundred twenty‐eight women were randomised to receive intravenous ( n = 63) or 65) stratified by gestational age (<28 ≥28 weeks). Atosiban was administered for up 48 hours. Progression...
To analyze the spectrum of prenatally diagnosed congenital heart disease in a Korean population with 22q11.2 deletion syndrome, and to provide guidelines for screening prenatally.This retrospective study evaluated 1,137 consecutive fetuses that had prenatal genetic testing because suspected between September 2002 December 2012, at Asan Medical Center, Seoul, Korea.Main cardiovascular diseases 53 confirmed deletions were tetralogy Fallot (n = 24, 45%), interrupted aortic arch 10, 19%),...
Objectives The purpose of this study was to determine the type an imperforate anus by using sonography in prenatal period. Methods This retrospective evaluated fetal all pregnant women, including low‐ and high‐risk populations, between February 2010 November 2013. High‐type anuses were diagnosed when anal sphincter muscles canal mucosa not visible. Low‐type prenatally suspected at least 1 following present: (1) a small anus; (2) no visible mucosa; or (3) close location genitalia without...
Abstract Background. This study was undertaken to describe the results of angiographic embolization for obstetrical hemorrhage and follow‐up outcome fertility. Methods. Consecutive patients who received management at a single tertiary center were included in this study. Medical records reviewed collect clinical data details on procedure. Patients interviewed by telephone obtain long‐term outcomes complications, menstruation, desire conception, subsequent pregnancies. Results. Embolization...
Covalent adduction of a nitrosyl group to cysteines [S-nitrosylation (S-NO)] is emerging as key route for nitric oxide (NO) directly modulate protein functions. Here, we studied the effects estrogens on endothelial S-NO and analyzed nitrosyl-proteomes by biotin/CyDye switch technique combined with two-dimensional fluorescence difference gel electrophoresis identified nitrosoproteins matrix-assisted laser desorption/ionization-time flight mass spectrometry. Estradiol-17beta (E2) rapidly...
We performed a post-hoc subgroup analysis in Korean women who participated the Phase III FER-ASAP (FERric carboxymaltose-Assessment of SAfety and efficacy Pregnancy) study to compare safety ferric carboxymaltose (FCM) with oral ferrous sulfate (FS). Pregnant (gestational weeks 16–33) iron-deficiency anemia (IDA) were randomized 1:1 FCM (n = 46; 1000–1500 mg iron) or FS 44; 200 iron/day) group for 12 weeks. The primary objective was mean hemoglobin (Hb) increase at week 3; secondary...
This study aimed to examine clinical practice patterns in the management of pregnant women admitted with threatened preterm labor (TPL) Korea. Data from a diagnosis TPL were collected 22 hospitals. was defined as regular uterine contractions or without other symptoms such pelvic pressure, backache, increased vaginal discharge, menstrual-like cramps, bleeding/show and cervical changes. on general patient information, characteristics at admission, use tocolytics, antibiotics, corticosteroids,...