A5102763489- Immunotherapy and Immune Responses
- Antibiotic Resistance in Bacteria
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Genetic Associations and Epidemiology
- Salmonella and Campylobacter epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Gene expression and cancer classification
- Asian Culture and Media Studies
- RNA Interference and Gene Delivery
- Vibrio bacteria research studies
- Chemokine receptors and signaling
- Virus-based gene therapy research
- Enterobacteriaceae and Cronobacter Research
- vaccines and immunoinformatics approaches
- Prenatal Screening and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
Korea Advanced Institute of Science and Technology
2023
Korea Disease Control and Prevention Agency
2020-2023
Korea Center for Disease Control and Prevention
2019-2021
SK Group (South Korea)
2015-2020
The University of Texas MD Anderson Cancer Center
2015-2020
Chonnam National University
2006-2017
Korea National Institute of Health
2006-2017
Seoul National University
2008-2012
Catholic University of Korea
2007-2011
Sookmyung Women's University
2010
Ischemia/reperfusion injury triggers acute kidney (AKI) by aggravating oxidative stress mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master player that regulates mitochondrial biogenesis and the antioxidant response. We postulated PGC-1α functions as cytoprotective effector in renal cells its regulation mechanism coordinated nuclear factor erythroid 2-related 2 (Nrf-2). In this study, to understand effect molecular...
Abstract Amid great controversy, the South Korean National Assembly passed Overseas Act (OKA) on December 3, 1999. The benefits, which resemble quasi-citizenship rights, are justified by government’s drive to redefine and reconstruct identity in context of an increasingly globalized world. Certain overseas groups legally included as (quasi) members nation-state, whereas other remain legal outsiders. Many people argue that OKA defines “Korean identity” through technical connections Korea,...
In this study, we investigated the potential of combined treatment with temozolomide (TMZ) chemotherapy and tumor antigen-pulsed dendritic cells (DCs) underlying immunological factors TMZ chemoimmunotherapy an intracranial GL26 glioma animal model. The enhanced tumor-specific immune responses prolonged survival more effectively than either single therapy in tumor-bearing animals. Apoptosis was induced tumors animals by TMZ. Calreticulin (CRT) surface exposure detected immunofluorescence...
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic modifications, resulting senescence. We compared differential methylation patterns of genes miRNAs between early-passage [passage 5 (P5)] late-passage (P15) estimated the relationship senescence DNA patterns. When we examined hypermethylated (methylation peak ≥ 2) at P5 P15, 2,739 genes,...
Abstract BACKGROUND Noninvasive prenatal diagnosis of monogenic disorders using maternal plasma and targeted massively parallel sequencing is being investigated actively. We previously demonstrated that comprehensive genetic a Duchenne muscular dystrophy (DMD) patient feasible single platform. Here we demonstrate the applicability this approach to carrier detection noninvasive diagnosis. METHODS Custom solution-based target enrichment was designed cover entire dystrophin gene region....
Although chemotherapy remains among the best treatment options for most cancers, adjuvant therapies such as dendritic cell (DC)-based immunotherapy have been added to protocols destroy residual tumour cells. Combination with low-dose temozolomide (TMZ) followed by vaccination TAT-survivin-pulsed DCs enhanced T-cell responses specific survivin and improved survival rate, compared DC alone or TMZ alone. Moreover, antigen-specific immunity appears be mediated CD8(+) T cells, determined in vitro...
In complex organisms, different tissues express genes, which ultimately shape the function and phenotype of each tissue. An important goal modern biology is to understand how some genes are turned on off in specific numbers gene expression products determined. These aspects named 'expression breadth' (or 'tissue specificity') level', respectively. Here, we show that can predict substantial amount variation levels breadths using genomic information gene. Interestingly, many traits correlated...
Abstract Cytotoxic T lymphocyte (CTL)–based immunotherapies have had remarkable success at generating objective clinical responses in patients with advanced metastatic melanoma. Although the melanocyte differentiation antigens (MDA) MART-1, PMEL, and tyrosinase were among first melanoma tumor-associated identified targeted immunotherapy, expression within normal melanocytes of eye inner ear can elicit serious autoimmune side effects, thus limiting their potential as CTL targets. Using a...
Clinical response rates after adoptive cell therapy (ACT) are highly correlated with in vivo persistence of the infused T cells. However, antigen-specific cells found tumor sites often well-differentiated effector limited persistence. Central memory CD8+ cells, capable self-renewal, represent desirable ACT products. We report here that exposure to a histone deacetylase inhibitor (HDACi) and IL21 could reprogram differentiated human into central memory-like Dedifferentiation was initiated by...
We investigated the possibility of immunotherapy for multiple myeloma (MM) using myeloma-specific cytotoxic T lymphocytes (CTLs) that were stimulated in vitro by dendritic cells (DCs) pulsing with purified and optimized lysates. CD14+ cultured presence GM-CSF IL-4. On day 6, immature DCs pulsed cell lysates, then maturation was induced addition a cytokine cocktail. There no differences phenotypic expressions mature generated CD138+ lysates or total In optimization concentration 10 µg/mL...
DNA methylation reprogramming (DMR) during preimplantation development erases differentiation-associated, unessential epigenetic information accumulated gametogenesis, and ultimately brings pluripotency to the resulting embryo. Two patterns of DMR sperm-derived pronucleus have been reported in mammals. In first, male is actively demethylated whereas second, state seems be maintained. The maintenance-type has seen only through immunocytochemical observations, waits proven by additional...
Monoacetyldiglycerides purified from deer antler, and identical synthetic compounds, have been shown to stimulate hematopoiesis. In the present study, we synthesized eight monoacetyldiglycerides, one of which, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (3), was structurally naturally occurring monoacetyldiglycerides showed most potent stimulation hematopoiesis by colony forming unit in culture (CFUc) assay, having a index (SI) 1.54±0.23 at concentration 1.0 μg/ml. Moreover, μg/ml 3...
Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from maternal plasma for aneuploidy identification is expanding worldwide. The objective of this study was to evaluate the clinical utility NIPT detection trisomies 21, 18, and 13 high-risk fetus in a large Korean population.
It is controversial as to whether papillary thyroid microcarcinoma (PTMC) has some genomic and transcriptomic characteristics that differentiate between an early-stage lesion would eventually evolve into the larger cancer (PTC), occult indolent in itself. To investigate this, we comprehensively elucidated landscapes of PTMCs different sizes, using a large-scaled database. This study included 3435 PTCs, 1985 which were PTMCs. We performed targeted next-generation sequencing for 221 PTCs...
Although dendritic cells (DC) have been well demonstrated as a strong cellular adjuvant for tumor vaccine, there are several limitations clinical application. A protein‐based vaccine using potent is an appealing approach antigen‐specific immunotherapy because of their simplicity, safety, efficacy and capacity repeated administration. CpG‐oligodeoxynucleotides (ODN) used adjuvants to stimulate innate adaptive immune responses cancer treatment. The authors evaluated the effects CpG‐ODN in...