A5004656794- Nail Diseases and Treatments
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Fungal Biology and Applications
- Influenza Virus Research Studies
- Advanced X-ray and CT Imaging
- Plant Pathogens and Fungal Diseases
- Viral gastroenteritis research and epidemiology
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Animal Disease Management and Epidemiology
- Bee Products Chemical Analysis
- Medical Imaging Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Digital Radiography and Breast Imaging
- Advanced MRI Techniques and Applications
- Pharmacy and Medical Practices
- Diverse Approaches in Healthcare and Education Studies
- Spacecraft and Cryogenic Technologies
- Viral Infections and Vectors
- Corneal Surgery and Treatments
- Advanced Computing and Algorithms
Animal and Plant Quarantine Agency
2021-2025
Kyung Hee University
2024-2025
Gachon University
2020-2024
Samsung (South Korea)
2024
Sungkyunkwan University
2024
Sungmo Eye Hospital
2023
Chung-Ang University
2014-2023
Hanyang University
2015-2023
National Cancer Center
2021-2022
Dong-A University
2022
Abstract Natural killer (NK) cells are crucial in the innate immune response and show promise cancer immunotherapy, but face challenges activation targeted gene delivery. In this study, bifunctional lipid nanoparticles (DLNPs) containing 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP), designed to bolster antitumor efficacy of chimeric antigen receptor‐modified NK (CAR‐NK) by facilitating efficient CAR mRNA delivery introduced. The DLNPs, created functionalizing FDA‐approved LNP...
Pathogenic microbes secrete various enzymes with lipolytic activities to facilitate their survival within the host. Lipolytic include extracellular lipases and phospholipases, several lines of evidence have suggested that these contribute virulence pathogenic fungi. Candida albicans Cryptococcus neoformans are most commonly isolated human fungal pathogens, biochemical molecular approaches identified enzymes. The role phospholipases in C. has been extensively studied, shown morphological...
Abstract Chronic hepatitis B virus (HBV) infection can cause cirrhosis and hepatocellular carcinoma is therefore a serious public health problem. Infected patients are currently treated with nucleoside/nucleotide analogs interferon α, but this approach not curative. Here, we screen 978 FDA-approved compounds for their ability to inhibit HBV replication in HBV-expressing HepG2.2.15 cells. We find that ciclopirox, synthetic antifungal agent, strongly inhibits cells mice by blocking capsid...
Abstract Dandruff is known to be associated with Malassezia restricta . Zinc pyrithione (ZPT) has been used as an ingredient in anti-dandruff treatments. The mechanism of ZPT investigated several studies; however, a non-pathogenic model yeast, such Saccharomyces cerevisiae was most often used. aim the present study understand how inhibits growth M. We analyzed cellular metal content and transcriptome profile ZPT-treated cells found that treatment dramatically increased zinc levels, along...
Malassezia species are opportunistic pathogenic fungi that frequently associated with seborrhoeic dermatitis, including dandruff. Most lipid dependent, a property is compensated by breaking down host sebum into fatty acids lipases. In this study, we aimed to sequence and analyse the whole genome of restricta KCTC 27527, clinical isolate from Korean patient severe dandruff, search for lipase orthologues identify most expressed on scalp patients The M. 27527 was sequenced using Illumina MiSeq...
During the 2022-2023 winter season in South Korea, a novel clade 2.3.4.4b H5N1 HPAIV was first detected wild birds, which then subsequently caused multiple outbreaks poultry farms and birds. This study aimed to investigate genetic characteristics of HPAIVs isolated during 2022-2023, along with their pathogenicity transmissibility chickens ducks. The viruses 75 174 bird cases. Phylogenetic analysis hemagglutinin genes revealed that Korean isolates were closely related Eurasian American...
Background: As the population ages, enhancing immune function is crucial to mitigating age-related physiological decline. Since immunostimulant drugs are known have potential side effects, medicinal plants emerge as promising candidates offering a safer alternative. To leverage advantages of with fewer effects and develop potent immune-enhancing agent, we investigated efficacy novel immunomodulatory candidate derived from combination Angelica gigas Pueraria lobata (CHL). Methods: In vitro,...
Woodfordia uniflora is a flowering shrub unique to the Dhofar region of Oman and used locally as sedative remedy for skin infection. However, no study date has examined pharmacological properties this plant, studies regarding phytochemicals present in W. are limited. Herein, phytochemical screening extract was performed using LC/MS. Three new phenolic compounds, (±)-woodfordiamycin (1), woodfordic acid (2), rhamnetin 3-O-(6″-galloyl)-β-d-glucopyranoside (3), together with 16 known compounds...
Malassezia is the most dominant fungal genus on human skin surface and associated with various diseases including dandruff seborrheic dermatitis. Among species, restricta widely observed species skin. In current study, we identified a novel dsRNA virus, named MrV40, in M. characterized sequence structure of viral genome along an independent satellite segment. Moreover, expression genes involved ribosomal synthesis programmed cell death was altered, indicating that virus infection affected...
Since its first appearance in 1996, H9N2 avian influenza virus (AIV) of the Y439 lineage persisted Korean live bird markets (LBMs) until last documented occurrence 2018. However, June 2020, surveillance program detected a novel AIV belonging to Y280 lineage, which has zoonotic potential, native chicken (KNC) from LBM. In this study, we infected KNCs and ducks (the 2 major species held at LBMs), as well SPF chickens, with Y280-lineage LBM261/20 Y439-equivalent LBM294/18 compare pathogenicity...
Chronic alcohol consumption is associated with intestinal fungal dysbiosis, yet we understand little about how alterations of fungi (mycobiota) contribute to the pathogenesis alcohol-associated liver disease. By reanalyzing internal transcribed spacer 2 amplicon sequencing fecal samples from a cohort 66 patients use disorder for presence (as opposed relative abundance) species, observed that Malassezia restricta was increased markers injury. M. exacerbates ethanol-induced injury both in...
Purpose A boundaryless career perspective suggests that competencies are essential for employees who wish to advance their careers in high uncertainty. This study aims propose an integrated conceptual model provide insights and organizations by identifying what how one can prepare support development uncertain complex work environment. Design/methodology/approach The literature reviewed was adapted a competencies. All 77 studies were reviewed, guided the intelligent theory (ICT) social...
Malassezia restricta is an opportunistic fungal pathogen on human skin; it associated with various skin diseases, including seborrheic dermatitis and dandruff, which are usually treated using ketoconazole. In this study, we clinically isolated ketoconazole-resistant M. strains (KCTC 27529 KCTC 27550) from patients dandruff. To understand the mechanisms of ketoconazole resistance in isolates, their genomes were sequenced compared susceptible reference strain 27527. Using comparative genome...
High pathogenicity avian influenza (HPAI) viruses of clade 2.3.4.4 H5Nx have been circulating in poultry and wild birds worldwide since 2014. In South Korea, after the first 2.3.4.4b H5N1 HPAI were isolated from October 2021, additional HPAIV outbreaks occurred farms until April 2022. this study, we genetically characterized isolates 2021-2022 examined transmissibility A/mandarin duck/Korea/WA585/2021 (H5N1) (WA585/21) chickens ducks. Clade caused 47 also detected multiple birds....
Prenatal caffeine exposure adversely affects the development of reproductive organs male rat offspring. Thus, it is conceivable that peripubertal would also influence physiologic gonadal changes and function during this critical period for sexual maturation. This study investigated impact high doses on testes prepubertal rats. A total 45 immature rats were divided randomly into three groups: a control group 2 groups fed 120 180 mg/kg/day caffeine, respectively, via stomach 4 weeks. Caffeine...
Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis. We aimed to determine whether cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against species, could improve SD symptoms. instructed 24 patients mild-to-moderate apply the C/P and emollient on right left sides of face, respectively, every morning evening for 4 weeks. The casual sebum level (measured Sebumeter®; Courage &...
Malassezia is the fungus predominantly residing on human skin and causes various diseases, including seborrheic dermatitis dandruff. To date, 18 species have been reported, among them, M. restricta most predominant skin, especially scalp.
During the 2020-2021 winter season, an outbreak of clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) virus occurred in South Korea. Here, we evaluated and transmissibility A/mandarin duck/Korea/H242/2020 (H5N8) (H242/20(H5N8)) first isolated from this specific pathogen-free (SPF) chickens commercial ducks comparison with those A/duck/Korea/HD1/2017(H5N6) (HD1/17(H5N6)) a previous HPAI 2017-2018. In chickens, 50% chicken lethal dose mean death time H242/20(H5N8) group were 104.5...