A5102829729- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Bacteriophages and microbial interactions
- Graphene and Nanomaterials Applications
- Tribology and Wear Analysis
- Glycosylation and Glycoproteins Research
- Electromagnetic wave absorption materials
- Advanced Biosensing Techniques and Applications
- Advanced Wireless Communication Technologies
- Advanced Antenna and Metasurface Technologies
- Enzyme Structure and Function
- Cancer Research and Treatments
- Antenna Design and Analysis
- Inertial Sensor and Navigation
- Microbial Inactivation Methods
Sungkyunkwan University
2022-2025
Seoul National University
2012-2024
Korea Research Institute of Bioscience and Biotechnology
2024
Sejong University
2023
Catholic University of Korea
2016-2022
Yonsei University
2021
Government of the Republic of Korea
2017
Bucheon University
2017
Samsung (South Korea)
2011-2014
Korea Advanced Institute of Science and Technology
2008-2014
Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due their unique structural and biophysical features. We here present the development a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin composed Leucine-rich repeat modules in jawless vertebrates, by module engineering. A template was first constructed joining consensus between N- C-capping motifs receptors. The N-terminal domain redesigned...
Photodynamic therapy (PDT) is a widely used clinical option for tumor therapy. However, the utilization of conventional small-molecule photosensitizers (PSs) PDT has been limited by their low selectivity disease sites, and undesirable photoactivation. To overcome these limitations, we demonstrated tumor-specific photoactivity-controllable nanoparticle photomedicine based on combination PS–biomacromolecule conjugates polydopamine nanoparticles (PD-NP) an effective This novel consisted PD-NP...
Smart photosensitizers (PSs), combined with advanced nano- and biomaterial technology, have a great potential for efficient cancer treatment.
Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan address these issues. Glycol is natural adjuvant, inducing dendritic cell activation promote T helper 1 immune responses, macrophage activation, cytokine production. Effective antigen production by cells initiates T-cell-mediated aiding growth control.
Abstract Natural killer (NK) cells are crucial in the innate immune response and show promise cancer immunotherapy, but face challenges activation targeted gene delivery. In this study, bifunctional lipid nanoparticles (DLNPs) containing 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP), designed to bolster antitumor efficacy of chimeric antigen receptor‐modified NK (CAR‐NK) by facilitating efficient CAR mRNA delivery introduced. The DLNPs, created functionalizing FDA‐approved LNP...
Abstract Here, described are additional treatment strategies that make use of human mesenchymal stem cell (hMSC)‐based local immunotherapeutic agents for the solid tumors. Dibenzocyclooctyne‐poly(ethylene glycol)‐pheophorbide A conjugates engineered surface conjugation by copper‐free click chemistry and subsequently conjugated to hMSC (hMSC‐DPP). hMSC‐DPP can recognize migrate toward cancer lesions, where they secrete pro‐inflammatory cytokines such as interleukin (IL)‐6, IL‐8, heat shock...
Abstract The efficacy of radiotherapy is often limited by insufficient radiosensitization and tumor radioresistance. This study reports a dual‐functional hafnium oxide nanoplatform that combines high‐Z with Bcl‐2 gene silencing for enhanced cancer radiotherapy. developed surface modification nanoparticles polyethyleneimine, enabling efficient siRNA delivery while maintaining inherent radiosensitizing properties. Comprehensive physicochemical characterization confirmed the successful stable...
Lifetime-reconfigurable soft robots have emerged as a new class of robots, emphasizing the unmet needs futuristic sustainability and security. Trigger-transient materials that can both actuate degrade on-demand are crucial for achieving life-reconfigurable robots. Here, we propose use transient magnetically actuating decompose under ultraviolet light heat, achieved by adding photo-acid generator (PAG) magnetic particles (Sr-ferrite) to poly(propylene carbonate) (PPC). Chemical thermal...
Repeat proteins are increasingly attracting much attention as alternative scaffolds to immunoglobulin antibodies due their unique structural features. Nonetheless, engineering interaction interface and understanding molecular basis for affinity maturation of repeat still remain a challenge. Here, we present structure-based rational design protein with high binding target protein. As model protein, Toll-like receptor4 (TLR4) decoy receptor composed leucine-rich (LRR) modules was used, its...
Repeat proteins have recently attracted much attention as alternative scaffolds to immunoglobulin antibodies due their unique structural and biophysical features. In particular, repeat show high stability against temperature chaotic agents. Despite many studies, features for the of remain poorly understood. Here we present an interesting result from in silico analyses pursuing factors which affect proteins. Previously developed repebody structure based on variable lymphocytes receptors...
Macrophages are present in all tissues for maintaining tissue homeostasis, and macrophage polarization plays a vital role alleviating inflammation. Therefore, specific delivery of modulators to macrophages situ is critical treating inflammatory diseases. We demonstrate that size-controlled miRNA-encapsulated macrophage-targeting liposomes (miR/MT-Lip) specifically targets promote M1-to-M2 conversion, inflammation without cytotoxicity. miR/MT-Lip, approximately 1.2 μm, showed excellent...