A5101951386- Computational Drug Discovery Methods
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Enzyme function and inhibition
- Click Chemistry and Applications
- Histone Deacetylase Inhibitors Research
- Heat shock proteins research
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Cholinesterase and Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Redox biology and oxidative stress
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Bioactive natural compounds
- Biochemical effects in animals
- Natural Antidiabetic Agents Studies
- Enzyme Structure and Function
- Sirtuins and Resveratrol in Medicine
- HIV/AIDS drug development and treatment
- Receptor Mechanisms and Signaling
- DNA and Nucleic Acid Chemistry
- Microtubule and mitosis dynamics
Gyeongsang National University
2015-2024
Korea Basic Science Institute
2024
Institute of Natural Science
2018-2022
Kolon Industries (South Korea)
2020-2021
Osmania University
2020
Inje University
2017
Eulji University
2013-2015
Eulji General Hospital
2015
Sungkyunkwan University
2015
Catholic University of Daegu
2013
Abstract It has been suggested that plant phytochromes are autophosphorylating serine/threonine kinases. However, the biochemical properties and functional roles of putative phytochrome kinase activity in light signalling largely unknown. Here, we describe characterization Avena sativa A (AsphyA) as a potential protein kinase. We provide evidence phytochrome-interacting factors (PIFs) phosphorylated by vitro . Domain mapping AsphyA shows photosensory core region consisting PAS-GAF-PHY...
A crucial prerequisite for plant growth and survival is the maintenance of potassium uptake, especially when high sodium surrounds root zone. The Arabidopsis HIGH-AFFINITY K+ TRANSPORTER1 (HKT1), its homologs in other salt-sensitive dicots, contributes to salinity tolerance by removing Na+ from transpiration stream. However, TsHKT1;2, one three HKT1 copies Thellungiella salsuginea, a halophytic relative, acts as transporter presence yeast (Saccharomyces cerevisiae). Amino-acid sequence...
Recently, the world has been witnessing a global pandemic with no effective therapeutics yet, while cancer continues to be major disease claiming many lives. The natural compound curcumin is bestowed multiple medicinal applications in addition demonstrating antiviral and anticancer activities. In order elucidate impact of on COVID-19 cancer, current investigation adapted several computational techniques unfold its possible inhibitory activity. Accordingly, similar compounds analogues were...
Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. Melatonin potent antioxidant that exerts protective effects in different experimental models. In this study, melatonin were demonstrated proteomic silico approach. The study identified differentially expressed proteins 2D gel electrophoresis...
Antibiotic resistance is a defense mechanism, harbored by pathogens to survive under unfavorable conditions. Among several antibiotic resistant microbial consortium, Staphylococcus aureus one of the most havoc microorganisms. encodes unique enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), against which, none existing antibiotics have been reported. Computational approaches instrumental in designing and discovering new drugs for diseases. The present study highlights...
Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely impacts food quality, human health, biodiversity, the environment. Due to its small size unavailability of sensitive sensors, detection malathion remains challenging task. Often chromatographic methods employed analyze OPCs suffer from several shortcomings, including cost, immobility, laboriousness, unsuitability for point-of-care settings. Hence, developing specific diagnostic sensor quick inexpensive...
Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a single-membrane belongs to the aspartyl protease class of catabolic enzymes. This involved in processing (APP). The cleavage APP by BACE-1 rate-limiting step cascade leading production two peptide fragments Aβ40 and Aβ42. Among Aβ42 primary species thought be responsible for neurotoxicity plaque formation that lead memory cognitive defects Alzheimer's disease (AD). AD ravaging neurodegenerative disorder which no...
Abstract Vibrational spectral analysis was carried out for 4‐methoxy‐2‐methyl benzoic acid (4M2MBA) by using Fourier transform infrared (FT‐IR) (solid, gas phase) and FT‐Raman spectroscopy in the range of 400–4000 10–3500 cm −1 respectively. The effects molecular association through OH···O hydrogen bonding have been described single dimer structure. theoretical computational density functional theory (DFT) Hatree‐Fock (HF) method were performed at 6–311++G(d,p) levels to derive equilibrium...
Abstract Background Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion angiotensinogen to angiotensin I is first and rate-limiting step renin-angiotensin system thus designing inhibitors block this focused study. Methods Ligand-based quantitative pharmacophore modeling methodology was used identifying important molecular chemical features present set already known active compounds...
Human chymase is a very important target for the treatment of cardiovascular diseases. Using series theoretical methods like pharmacophore modeling, database screening, molecular docking and Density Functional Theory (DFT) calculations, an investigation identification novel inhibitors, to specify key factors crucial binding interaction between inhibitors performed. A highly correlating (r = 0.942) model (Hypo1) with two hydrogen bond acceptors, three hydrophobic aromatic features generated....
TRIM32, which belongs to the tripartite motif (TRIM) protein family, has RING finger, B-box, and coiled-coil domain structures common this along with an additional NHL at C terminus. TRIM32 reportedly functions as E3 ligase for actin, a inhibitor of activated STAT y (PIASy), dysbindin, c-Myc, it been associated diseases such muscular dystrophy epithelial carcinogenesis. Here, we identify new substrate propose mechanism through might regulate apoptosis. Our overexpression knockdown...
Angiogenesis is a process of formation new blood vessels and an important criteria demonstrated by cancer cells. Over period time, these cells infect the other parts healthy body called progression. The objective present article to identify drug molecule that inhibits angiogenesis In this pursuit, ligand based pharmacophore virtual screening was employed, generating model, Hypo1 consisting four features. Furthermore, validated recruiting, Fischer's randomization, test set method decoy...
Sinensetin (SIN) has been reported to exhibit anti-inflammatory and anti-cancer activity. However, the cellular molecular mechanism by which SIN promotes hepatocellular carcinoma (HCC) cell death remains unclear. In present study, we investigated induction of its underlying in HepG2 cells, an HCC line. We found that significantly induced whereas proliferation rate Thle2, human liver epithelial was unaffected SIN. SIN-treated cells were not affected apoptotic death; instead, autophagic...