A5018284789- Natural product bioactivities and synthesis
- Phytoestrogen effects and research
- Protein Tyrosine Phosphatases
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- GABA and Rice Research
- Carbohydrate Chemistry and Synthesis
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Food Quality and Safety Studies
- Marine Sponges and Natural Products
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Probiotics and Fermented Foods
- Crystallization and Solubility Studies
- Soybean genetics and cultivation
- X-ray Diffraction in Crystallography
- Microbial Natural Products and Biosynthesis
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Bioactive Compounds
- Natural Compound Pharmacology Studies
- Medicinal Plant Pharmacodynamics Research
- Bioactive natural compounds
- Liver Disease Diagnosis and Treatment
- Phytochemistry and biological activity of medicinal plants
Huanghuai University
2025
Gyeongsang National University
2014-2023
University of Florida
2020-2021
Yonsei University
1996
Tribulus terrestris fruits are well known for their usage in pharmaceutical preparations and food supplements. The methanol extract of T. showed potent inhibition against the papain-like protease (PLpro), an essential proteolylic enzyme protection to pathogenic virus bacteria. Subsequent bioactivity-guided fractionation this led six cinnamic amides (1–6) ferulic acid (7). Compound 6 emerged as new compound possessing very rare carbinolamide motif. These compounds (1–7) were evaluated severe...
Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase are important targets to treat obesity diabetes, due their deep correlation with insulin leptin signalling, glucose regulation. The methanol extract of Paulownia tomentosa fruits showed potent inhibition against both enzymes. Purification this led eight geranylated flavonoids (1-8) displaying dual PTP1B α-glucosidase. isolated compounds were identified as flavanones (1-5) dihydroflavonols (6-8). Inhibitory potencies these varied...
Dietary isoflavones, daidzein and genistein are of huge interest in the nutraceutical field due to their practical application postmenopause complications. This study is first report an efficient method prepare isoflavone rich soybean leaves (soyleaves) which edible food stuff Asian countries. The preharvest treatment ethylene highly stimulated level soyleaves. Annotation quantification metabolites were determined by UPLC-Q-TOF-MS HPLC. Phenolic soyleaves mostly kaempferol glycosides, but...
This research was the first to demonstrate changes in nutritional compositions (isoflavone and CLA) from 50% methanol extracts of soy-powder milk (SPM) yogurt (SPY) through fermentation using Lactobacillus plantarum S48 P1201 strains. The radical scavenging activities protective effects against oxidative stress LLC-PK1 cells were also investigated. average physicochemical characteristics including acidity viable cell number as well β-glucosidase activity increased with 0.2 → 0.7%, 7.5 9.8...
Abstract BACKGROUND Increased soil salt concentration decreases productivity and changes the physiological chemical properties of plants. Various omics technologies have been used to understand response in plants but overall metabolite profiles spinach ( Spinacia oleracea L.) under stress not studied. In this article, therefore, mineral cultivated with different NaCl concentrations 0–200 mmol L –1 irrigation water were analyzed investigate effect on nutritional quality. RESULTS Increasing...
Citrus fruits undergo significant metabolic profile changes during their development process. However, limited information is available on the in metabolites of unshiu fruit development. Here, we analyzed total phenolic content (TPC), carotenoid (TCC), antioxidant activity, and metabolite profiles C. flesh different stages evaluated correlations. The TPC activity significantly decreased development, whereas TCC increased. profiles, including sugars, acidic compounds, amino acids, flavonoids,...
Plants produce diverse secondary metabolites. Although each metabolite is made through its respective biosynthetic pathway, plants coordinate multiple pathways simultaneously. One example an interaction between glucosinolate and phenylpropanoid in Arabidopsis thaliana. Glucosinolates are defense compounds primarily from methionine tryptophan, while phenylpropanoids phenylalanine. Recent studies have shown that the accumulation of intermediate such as indole-3-acetaldoxime (IAOx) or...
This study evaluated the changes in γ-aminobutyric acid (GABA) and isoflavone aglycone contents from soy powder yogurt (SPY) due to sprouting of soybean (1 cm) fermentation with Lactobacillus brevis. The levels GABA form increased, glutamate decarboxylase β-glucosidase activities increased; however, glycoside malonylglycoside decreased after for 72 h. In particular, 60 h, SPY presented highest content (120.38 mg/100 mL). daidzein (179.93 µg/g), glycitein (44.10 genistein (126.24 µg/g) were...
Diabetes mellitus is one of a major worldwide concerns, regulated by either defects in secretion or action insulin, both. Insulin signaling down-regulation has been related with over activity protein tyrosine phosphatase 1B (PTP1B) enzyme, which promising target for the treatment diabetes mellitus. Herein, guided separation methanol extract (95%) Dodonaea viscosa aerial parts afforded nine (1-9) polyphenolic compounds, all them were identified through spectroscopic data including 2D NMR and...
Activity-guided phytochemical investigation of the methanol extract Usnea longissima led to isolation nine (1–9) phenolic metabolites, including compounds 6 and 7, which were reported for first time from this species. All isolated completely characterized through spectroscopic analysis, 2D NMR HREIMS data. Individually, activity each purified compound was assessed against bacterial neuraminidase (BNA), most them displayed dose-dependent inhibition. Among compounds, 2 3 exhibited significant...