A5100741679- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Infectious Diseases and Tuberculosis
- Animal Disease Management and Epidemiology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Orthopedic Infections and Treatments
- Long-Term Effects of COVID-19
- Infection Control and Ventilation
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Pneumonia and Respiratory Infections
- Acne and Rosacea Treatments and Effects
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Dermatology and Skin Diseases
- Peripheral Neuropathies and Disorders
- COVID-19 and healthcare impacts
Chonnam National University Hospital
2022-2025
Chung-Ang University Hospital
2017-2024
Korea Research Institute of Chemical Technology
2024
Kyungpook National University
2023-2024
Chung-Ang University
2017-2024
Kim's Eye Hospital
2023-2024
Konyang University
2024
Illinois College
2016-2022
University of Illinois Urbana-Champaign
2016-2022
Chonnam National University Hwasun Hospital
2013-2022
Duration of Positive SARS-CoV-2 on RT-PCR and Culture In 21 consecutive patients with confirmed Covid-19, the median times from symptom onset to negative viral culture real-time RT-PCR...
Background Current influenza vaccines based on the hemagglutinin protein are strain specific and do not provide good protection against drifted viruses or emergence of new pandemic strains. An vaccine that can confer cross-protection antigenically different A strains is highly desirable for improving public health. Methodology/Principal Findings To develop a cross protective vaccine, we generated virus-like particles containing conserved M2 in membrane-anchored form (M2 VLPs), investigated...
Lactobacillus plantarum DK119 (DK119) isolated from the fermented Korean cabbage food was used as a probiotic to determine its antiviral effects on influenza virus. intranasal or oral administration conferred 100% protection against subsequent lethal infection with A viruses, prevented significant weight loss, and lowered lung viral loads in mouse model. The protective efficacy observed dose route dependent manner of administration. Mice that were treated showed high levels cytokines IL-12...
The severity of COVID-19 ranges from mild to critical diseases. However, limited data have been published on the detailed kinetics viral load and host immune response throughout disease course depending severity. In this study, we comprehensively analyzed load, antibody responses SARS-CoV-2, cytokines/chemokines during course, identified factors related Nasopharyngeal (NP) plasma specimens were obtained 31 patients with hospitalization. Viral RNA in NP was quantified by reverse...
Abstract During the 2006–2007 winter season in South Korea, several outbreaks of highly pathogenic avian influenza virus (H5N1) were confirmed among domestic poultry and migratory bird habitats. Phylogenetic analysis showed that all isolates closely related belong to A/bar-headed goose/Qinghai/5/2005–like lineage rather than A/chicken/Korea/ES/2003–like lineage.
Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng (GP) would a preventive effect on influenza infection. Administration of mice with GP prior infection was found confer survival benefit against H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) viruses. Mice infected the 2009 virus suspended in solution showed moderately enhanced rates lower levels lung viral titers inflammatory cytokine (IL-6). Daily treatment...
The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity healthcare systems, and the quality medical care. We assessed clinical outcomes COVID-19 during first wave epidemic in Korea.
Emerging resistance to colistin in clinical Acinetobacter baumannii isolates is of growing concern. Since current treatment options for these strains are extremely limited, we investigated the vitro activities various antimicrobial combinations against colistin-resistant A. Nine (8 from bacteremia cases and 1 a pneumonia case) were collected Asan Medical Center, Seoul, South Korea, between January 2010 December 2012. To screen potential synergistic effects, multiple two antimicrobials among...
Background Data on the filtration efficacies of various masks against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited. We thus evaluate effectiveness surgical mask, N95 respirator and its equivalent (KF94 mask) in filtering SARS-CoV-2.
The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution reducing poor clinical outcomes, vaccine hesitancy an obstacle achieving high levels uptake. This represents particular risk patients with autoimmune diseases, group already at increased hospitalization outcomes related infection. there is paucity long-term safety efficacy data in current evidence...
Highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype have spread since 2003 in poultry and wild birds Asia, Europe Africa. In Korea, highly outbreaks took place 2003/2004, 2006/2007 2008. As isolates differ phylogenetically from 2003/2004 isolates, we assessed clinical responses chickens, ducks quails to intranasal inoculation index case virus, A/chicken/Korea/IS/06. All chickens died on 3 days 3-6 post-inoculation (DPI), respectively, whilst only showed signs mild...
Abstract Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain evidence of their safety patients with systemic autoimmune and inflammatory disorders (SAIDs). vaccination-related adverse events (AEs) SAIDs controls (HC) seven days post-vaccination were assessed COVAD study, a patient self-reported cross-sectional survey. Methods The survey was circulated early 2021 by >110 collaborators (94 countries) collect SAID details, vaccination...
Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Korean red extract (KRGE) in vitro and vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival human lung epithelial cells against RSV infection inhibited replication. addition, treatment suppressed expression RSV-induced inflammatory cytokine genes (IL-6 IL-8) formation reactive oxygen species cell cultures. Oral administration mice...
Viral lower respiratory tract infections (LRTIs) can present with a variety of computed tomography (CT) findings. However, identifying the contribution particular virus to CT findings is challenging due concomitant and limited data on in viral LRTIs. We therefore investigate different pure LRTIs.All patients who underwent bronchoalveolar lavage (BAL) were diagnosed LRTIs caused by parainfluenza (PIV), influenza virus, or syncytial (RSV) between 1998 2014 enrolled tertiary hospital Seoul,...
Results of a cost-benefit analysis intraoperative use liposomal bupivacaine for postsurgical pain management in patients undergoing total knee arthroplasty (TKA) are presented.In retrospective single-site study, clinical and cost outcomes were compared group 134 consecutive who received (by local infiltration) during TKA propensity score-matched historical cohort usual care (continuous femoral nerve blockade with conventional delivered via elastomeric pump).Postsurgical scores opioid similar...
Abstract Vaccine adjuvant effects in the CD4-deficient condition largely remain unknown. We investigated roles of combined monophosphoryl lipid A (MPL) and aluminum hydroxide (Alum) (MPL+Alum) inducing immunity after immunization CD4 knockout (CD4KO) wild-type (WT) mice with T-dependent influenza vaccine. MPL+Alum mediated IgG isotype-switched Abs, IgG-secreting cell responses, protection CD4KO mice, which were comparable to those WT mice. In contrast, Alum dependent on CD4+ T cells. was...
During the coronavirus disease (COVID-19) pandemic, social distancing was effective in controlling spread across South Korea. The impact of national on common respiratory virus infections has rarely been investigated. We evaluated weekly proportion negative polymerase chain reaction (PCR) test results and positive rates each during period (10th–41st weeks 2020) corresponding different years, utilizing surveillance dataset reported by Korean Center for Disease Control Prevention. proportions...
•Multi-drug resistant organisms (MDRO) were isolated from 8.6% of COVID-19 pneumonia.•MDROs detected 28% (13/47) among patients with culture data.•Long-term care facility stay was a risk factor for isolation organisms.•Corticosteroids use in may increase the bacterial co-infection.•Strict infection prevention strategies be needed factors. ObjectivesSuperimposed multi-drug (MDROs) co-infection can associated worse outcomes severe coronavirus disease 2019 (COVID-19), even if these managed...
It remains unclear whether high titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies aggravate clinical manifestations in patients or result antibody titers. Thus, we investigated the cause-effect relationship between SARS-CoV-2 and disease severity.We prospectively enrolled admitted with diagnosis disease-19 (COVID-19) from February 2020 to August 2020. We measured titers, namely anti-receptor-binding domain (RBD) neutralizing (NAb), blood samples calculated...