A5002973930- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Diagnosis and treatment of tuberculosis
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Orthopedic Infections and Treatments
- Respiratory viral infections research
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Nosocomial Infections in ICU
- HIV/AIDS Research and Interventions
- Bacterial biofilms and quorum sensing
Jikei University School of Medicine
2022-2024
International Vaccine Institute
2023-2024
Korea Tourism College
2024
Korea Advanced Institute of Science and Technology
2021-2023
Ulsan College
2012-2021
University of Ulsan
2012-2021
Asan Medical Center
2012-2021
University of Minnesota
2019-2021
Eulji University
2021
Kettering University
2020
Rationale: The role of viruses in pneumonia adults and the impact viral infection on mortality have not been elucidated. Previous studies significant limitations that they relied predominantly upper respiratory specimens.Objectives: To investigate adult patients with requiring intensive care unit (ICU) admission.Methods: A retrospective analysis a prospective cohort was conducted 28-bed medical ICU. Patients severe community-acquired (CAP) or healthcare-associated (HCAP) were included...
Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii are characterized by chromosomally encoded AmpC beta-lactamases possess the ability to develop resistance upon exposure broad-spectrum cephalosporins. To determine incidences of emergence during antimicrobial therapy for infections caused these organisms effect on patient outcomes, all patients who were admitted Asan Medical Center (Seoul, Republic Korea) from January 2005 June 2006 whose clinical specimens...
Of the 27 healthcare workers (HCWs) who had contact with a fatally ill patient severe thrombocytopenia syndrome in Korea (SFTS), 4 were involved cardiopulmonary resuscitation complained of fever and diagnosed SFTS via seroconversion. Exposure to respiratory secretions, blood, or gowns soiled by body fluids was significantly associated infection HCWs.
Background. The optimal duration of antibiotic treatment for hematogenous vertebral osteomyelitis (HVO) should be based on the patient's risk recurrence, but it is not well established. Methods. A retrospective review was conducted to evaluate in patients with HVO at low and high recurrence. Patients least 1 independent baseline factor determined by multivariable analysis, were considered as those no risk. Results. total 314 microbiologically diagnosed evaluable In methicillin-resistant...
ABSTRACT Practice guidelines recommend at least 14 days of antibiotic therapy for uncomplicated Staphylococcus aureus bacteremia (SAB). However, these recommendations have not been formally evaluated in clinical studies. To evaluate the duration SAB, we analyzed data from our prospective cohort patients with SAB. A observational study was performed SAB a tertiary-care hospital Korea between August 2008 and September 2010. All adult were prospectively enrolled observed over 12-week period....
Background Viral pathogens have not generally been regarded as important causes of severe hospital-acquired pneumonia (HAP), except in patients with hematologic malignancy or transplant recipients. We investigated the role and distribution viruses adult HAP who required intensive care. Methods From March 2010 to February 2012, admission care unit (ICU), 28-bed medical ICU a tertiary hospital, were prospectively enrolled. Respiratory detected using multiplex reverse-transcription polymerase...
Persistent Staphylococcus aureus bacteremia (SAB) that fails to respond appropriate antibiotic therapy is associated with poor outcomes. Comprehensive prospective studies on risk factors and outcomes of persistent are limited. We investigated encompassing clinical, pharmacokinetic, microbiologic, genotypic characteristics using a case-control study nested in cohort patients SAB at tertiary-care hospital from August 2008 through September 2010. compared the clinical characteristics,...
The role of the new Myocbacterium tuberculosis-specific enzyme-linked immunosorbent spot (ELISPOT) assay for diagnosis tuberculous meningitis (TBM) has not yet been fully assessed. Here, we conducted a prospective, blinded, observational study to evaluate diagnostic accuracy this assay, compared with conventional tests, diagnosing TBM.All adult patients suspected TBM were enrolled at tertiary care hospital (Seoul, South Korea) during 12-month period. ELISPOT assays performed on peripheral...
We evaluated whether ELISPOT assay can predict tuberculosis (TB) development in kidney-transplantation (KT) recipients with a negative tuberculin skin test (TST). All adult patients admitted to KT institute between June 2008 and December 2009 were enrolled; TB after was observed 2010. Isoniazid (INH) given those positive TST or clinical risk factors for latent infection (LTBI). performed on all patients, by researcher blinded the results of ELISPOT. A total 312 including 242 (78%)...
Pseudomonas aeruginosa has gained an increasing amount of attention in the treatment patients with pneumonia. However, benefit empirical combination therapy for pneumonia remains unclear. We evaluated effects adequate and multidrug-resistance bacteremic on mortality.A retrospective cohort study was performed at 2,700-bed tertiary care university hospital. reviewed medical records between January 1997 February 2011. Patients who received either inappropriate or appropriate were compared by...
While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy non-HIV-infected PcP. Patients undergoing fiber-optic bronchoscopy bronchoalveolar lavage for suspected PcP from January 2007 through December 2010 were reviewed retrospectively. We compared demographics, clinical characteristics, and outcomes 88 (n = 59) without...
Emerging resistance to colistin in clinical Acinetobacter baumannii isolates is of growing concern. Since current treatment options for these strains are extremely limited, we investigated the vitro activities various antimicrobial combinations against colistin-resistant A. Nine (8 from bacteremia cases and 1 a pneumonia case) were collected Asan Medical Center, Seoul, South Korea, between January 2010 December 2012. To screen potential synergistic effects, multiple two antimicrobials among...
ABSTRACT Recent reports on some methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to vancomycin have been a major concern in Korea because of the widespread use due high prevalence MRSA country. We describe 45-year-old man long-standing pelvic abscess MRSA. In spite and teicoplanin treatment for long period time, patient died from sepsis. The blood culture isolate exhibited (MIC, 8 μg/ml). This is first report vancomycin-intermediate S. case Korea.
Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in transplant recipients and patients with neutropenia. Although IPA has been studied extensively neutropenic patients, there are limited data on solid organ transplants (SOTs). We compared the clinical features radiologic findings 27 SOT those 35 IPA. The were more likely than to show peribronchial consolidation (31% vs. 7%; P=0.03) or ground-glass opacity (38% P=0.007) less have fever (22% 80%; P<0.001),...
Of 149 patients with suspected cytomegalovirus (CMV) gastrointestinal disease, 51 (36%) confirmed cases, 6 (4%) probable and 64 (45%) instances of non-CMV disease were analyzed using the CMV antigenemia assay; 22 (5%) indeterminate excluded. The sensitivity specificity assay (defined as detection > or =1 positive cells per 200,000 leukocytes) for diagnosis 54% (95% confidence interval, 41%-68%) 88% 77%-94%), respectively.
In Epstein-Barr virus (EBV)-infected gastric carcinoma, EBV-encoded BARF1 has been hypothesized to function as an oncogene. To evaluate cellular changes induced by BARF1, we isolated the full-length gene from carcinoma cells that were naturally infected with EBV and transfected into EBV-negative cells. protein was primarily secreted culture supernatant only marginally detectable within Compared containing empty vector, BARF1-expressing exhibited increased cell proliferation (P < 0.05). There...
Mucormycosis is an uncommon and life-threatening fungal infection. The clinical predictors of outcome were evaluated in patients with invasive mucormycosis.We retrospectively reviewed histologically proven cases mucormycosis our institution from 1996 to 2012.A total 64 analyzed. median age was 59 years (interquartile range [IQR], 50-67), 32 (50%) male. most common underlying diseases diabetes mellitus (67%), hematologic malignancy (22%), solid cancer (19%). infection sites the...
ABSTRACT In November 2010, NDM-1-producing Klebsiella pneumoniae (NDMKP) was identified for the first time in South Korea from four patients with no history of traveling abroad who stayed 21 to 205 days a tertiary care hospital. All were sequence type (ST) 340 and had nearly identical XbaI pulsed-field gel electrophoresis (PFGE) patterns. The bla NDM-1 -carrying plasmids IncN group, sizes ranging 50 200 kb. These findings suggest that NDMKP already been introduced into before this clustering found.
ABSTRACT Few antiviral agents are available for treating paramyxovirus infections, such as those involving respiratory syncytial virus (RSV), parainfluenza (PIV), and human metapneumovirus (hMPV). We evaluated the effect of oral ribavirin on clinical outcomes infections in patients with hematological diseases. All adult were retrospectively reviewed over a 2-year period. Patients who received compared to supportive care without therapy. A propensity-matched case-control study logistic...