A5008244133- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Impact of Technology on Adolescents
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Child Development and Digital Technology
- Stress Responses and Cortisol
- Peroxisome Proliferator-Activated Receptors
- Pluripotent Stem Cells Research
- Heat shock proteins research
- Neurotransmitter Receptor Influence on Behavior
- Health and Wellbeing Research
- Memory and Neural Mechanisms
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- 14-3-3 protein interactions
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Gut microbiota and health
Ajou University
2021-2024
Hallym University
2023-2024
Catholic University of Korea
2014-2021
Seoul St. Mary's Hospital
2013-2021
Hanyang University
2008-2019
Anyang University
2019
Institute of Natural Science
2019
Indiana University – Purdue University Indianapolis
2011-2014
Indiana University School of Medicine
2011-2012
Susan G. Komen Breast Cancer Foundation
2012
Constipation is one of the most common gastrointestinal (GI) disorders worldwide. The use probiotics to improve constipation well known. In this study, effect on loperamide-induced by intragastric administration Consti-Biome mixed with SynBalance® SmilinGut (Lactobacillus plantarum PBS067, Lactobacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050; Roelmi HPC), L. UALp-05 (Chr. Hansen), acidophilus DDS-1 and Streptococcus thermophilus CKDB027 (Chong Kun Dang Bio) rats was...
Abstract The metabolites of gut microbiota show favorable therapeutic effects on nonalcoholic fatty liver disease (NAFLD), but the active and mechanisms against NAFLD have not been documented. aim study was to investigate by network pharmacology. We obtained a total 208 from gutMgene database retrieved 1256 targets similarity ensemble approach (SEA) 947 SwissTargetPrediction (STP) database. In SEA STP databases, we identified 668 overlapping 237 for NAFLD. Thirty-eight were out those 223...
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic modifications, resulting senescence. We compared differential methylation patterns of genes miRNAs between early-passage [passage 5 (P5)] late-passage (P15) estimated the relationship senescence DNA patterns. When we examined hypermethylated (methylation peak ≥ 2) at P5 P15, 2,739 genes,...
Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of cells in epidermis, driven an overactive immune system. Consequently, complex interplay among epidermal cells, and sensory neurons contributes to development progression psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP Ca2+ release-activated chloride potassium each serve specific functions maintain homeostasis skin. The dysregulation channels plays...
Abstract Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study to demonstrate the effect multistrain probiotics (Sensi-Biome) on diarrhea from perspective microbiome-neuron axis. Sensi-Biome ( Lactiplantibacillus plantarum , Bifidobacterium animalis subsp. lactis Lactobacillus acidophilus Streptococcus thermophilus bifidum and Lactococcus ) was administered 4% acetic acid–induced rat model at concentrations 1 × 10 8...
JMJD3, a Jumonji C family histone demethylase, is induced by transcription factor, nuclear factor‐kappa B (NF‐ κ B), in response to various stimuli. JMJD3 crucial for erasing histone‐3 lysine‐27 trimethylation (H3K27me3), modification associated with transcriptional repression and responsible the activation of diverse set genes. Here, we identify genes human leukaemia monocyte (THP‐1) monocytic cells that are significantly affected stable knockdown (kd) JMJD3. Global gene expression levels...
Chemotherapy is one of the therapeutic strategies that has been used for inhibition cancer cell proliferation in several types cancer, including prostate cancer. Although monoamine oxidase (MAO) inhibitors, phytoestrogen and antioxidants chemotherapy have systematically studied, their effects on growth remain to be fully understood. The purpose this study was investigate MAO pargyline tranylcypromine survival human carcinoma (LNCaP-LN3) cells. After treating LNCaP-LN3 cells with or...
Abstract Due to their multipotentiality and immunomodulation, human mesenchymal stem cells (hMSCs) are widely studied for the treatment of degenerative inflammatory diseases. Transplantation hMSCs damaged tissue is a promising approach regeneration. However, physiological mechanisms regulatory processes MSC trafficking injured largely unexplored. Here, we evaluated gene expression profile migratory potential upon stimulation with TLR4 ligand lipopolysaccharide (LPS). Using RNA sequencing,...
Multicentred hospital-based cases and control subjects in Korea.To evaluate the association between idiopathic pulmonary fibrosis (IPF) hazardous materials to which people are occupationally exposed.A multicentre, hospital-based, matched case-control study was performed. The ratio of IPF controls 1:1 (n = 78 each group). were terms age group, sex place residence. Conditional logistic regression analysis performed.In simple analysis, exposure metal dust any for >1 year an occupational setting...
Terminalia chebula (TC) is native to southern Asia southwestern China and used in traditional medicine for the treatment of human ailments including malignant tumors diabetes. This plant also has antibacterial immunomodulatory properties. Nuclear factor kappa‐light chain‐enhancer activated B cells (NF‐κB) responsible expression numerous genes involved cell survival, proliferation, angiogenesis, inflammation, invasion metastasis, among other processes. study aims assess NF‐κB inhibitory...
Cell culture of human-derived neural stem cells (NSCs) is a useful tool that contributes to our understanding human brain development and allows for the therapies intractable disorders. Human NSC (hNSC) cultures, however, are not commonly used, mainly because difficulty with consistently maintaining in healthy state. In this study, we show hNSC unlike NSCs rodent origins, extremely sensitive insulin, an indispensable supplement, previously reported culturing hNSCs likely lack relationship....
The aim of this study was to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) in the endometrium individuals with without EMS during proliferative (P) secretory (S) phases menstrual cycle. Tissues were obtained from 18 control (CT; P-phase [pCT], n=8; S-phase [sCT], n=13) 23 patients (P-phase [pEMS], n=13; [sEMS], n=12). DElncRNAs DEmRNAs analyzed using total RNA-sequencing. In P-phase, expression NONHSAG019742.2 NONHSAT120701.2 significantly higher than patients,...
Aims: Dopamine receptors are associated with reward and dependence towards alcohol. The polymorphisms of dopamine D2 receptor (DRD2) genes have been reported to be involved in susceptibility alcoholism. Therefore, we investigated the association three single-nucleotide (SNPs) DRD2 ankyrin repeat kinase domain containing one (ANKK1) alcohol Korean subjects, who were classified by criteria Lesch typology. Methods: −141C (Insertion (Ins)/Deletion (Del)), exon8 (A/G) ANKK1 TaqIA (A1/A2)...
Though Internet gaming disorder (IGD) is considered to share similar genetic vulnerability with substance addictions, little has been explored about the role of variants on IGD. This pilot study was designed investigate association Taq1A polymorphism ankyrin repeat and kinase domain containing 1 (ANKK1) gene C957T - 141C dopamine D2 receptor (DRD2) IGD their personality temperament traits in among adult population.Sixty-three subjects 87 control who regularly played games were recruited....
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate effect saponin on chronic ethanol-treated diabetic rats.Long-Evans Tokushima Fatty (LETO) Otsuka Long-Evans (OLETF) rats were pair-fed a Lieber-DeCarli diet with without 5% ethanol for 12 wks. Two weeks after starting pair-feeding diet, intraperitoneal injection performed 10 To...
The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus striatum after heroin administration cynomolgus macaques different ages.Cynomolgus monkeys were divided by age as follows: 1 year (A1, n = 2); 3 4 years (A2, 6 8 (A3, older than 11 (A4, 2). After injected intramuscularly into (0.6 mg/kg), we performed large-scale transcriptome profiling (H) (S) using RNA sequencing technology. Some validated with real-time quantitative PCR.In...
Abstract Background Women are more vulnerable than men to the neurotoxicity and severe brain damage caused by chronic heavy alcohol use. In addition, due use may be associated with sex-dependent epigenetic modifications. This study aimed identify microRNAs (miRNAs) their target genes that differentially expressed in hippocampi of male female animal models response alcohol. Methods After administration (3~3.5 g/kg/day) (control, n = 10; alcohol, 12) or Sprague-Dawley rats for 6 weeks, we...
Abstract In South Korea, the average age of onset alcohol drinking is 13.3 years and half adolescents drink more than once a month; 8.45% Korean adolescent population become future high‐risk drinkers. Chronic abuse causes physical psychiatric health problems such as addiction, liver disease, stroke cognitive impairments. This study aimed to investigate effect on gene expression their function in hippocampus rats. After chronic administration male (control, n = 6; alcohol, 6) Sprague‐Dawley...
Problematic smartphone use (PSU) is growing rapidly among teens. It has similar presentations as other behavioral addictions in terms of excessive use, impulse control problems, and negative consequences. However, the underlying neurobiological mechanisms remain undiscovered. We hypothesized that structural changes striatum might serve an important link between alteration glutamate signaling development PSU.Among 88 participants, twenty (F:M, 12:8; age 16.2 ± 1.1) reported high scores...