A5051905445- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Effects of Radiation Exposure
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer therapeutics and mechanisms
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
Memorial Sloan Kettering Cancer Center
2016-2025
Samsung (South Korea)
2013-2025
Cancer Research Center
2025
Kettering University
2016-2024
National NanoFab Center
2006-2023
Advanced Institute of Convergence Technology
2023
Radiation Oncology Associates
2023
New York Proton Center
2015-2019
University of California, Los Angeles
2007-2017
The University of Texas MD Anderson Cancer Center
2014-2017
Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived a single patient, are detected in normal and malignant human tissue, with highest levels observed late stage, castration-resistant cancer. The most studied variant (called AR-V7 or AR3) activates AR reporter genes absence of therefore, could play role castration resistance. To explore range potential ARVs, we screened additional murine models using...
Neoadjuvant chemotherapy (NAC) has proven survival benefits for patients with invasive urothelial carcinoma of the bladder, yet its role upper tract (UTUC) remains undefined. We conducted a multicenter, single-arm, phase II trial NAC gemcitabine and split-dose cisplatin (GC) high-risk UTUC before extirpative surgery to evaluate response, survival, tolerability.
Synaptopodin is the founding member of a novel class proline-rich actin-associated proteins highly expressed in telencephalic dendrites and renal podocytes. Synaptopodin-deficient (synpo–/–) mice lack dendritic spine apparatus display impaired activity-dependent long-term synaptic plasticity. In contrast, ultrastructure podocytes synpo–/– normal. Here we show that recovery from protamine sulfate–induced podocyte foot process (FP) effacement LPS-induced nephrotic syndrome. Similarly, actin...
There is increasing evidence that solid cancers contain cancer-initiating cells (CICs) are capable of regenerating a tumor has been surgically removed and/or treated with chemotherapy radiation therapy. Currently, cell surface markers, like CD133 or CD44, used to identify CICs in vitro; however, these markers cannot be and track vivo. The 26S proteasome the main regulator many processes within proliferating cell, its activity may altered depending on phenotype cell.Human glioma breast cancer...
Synaptopodin is the founding member of a novel class proline-rich actin-associated proteins highly expressed in telencephalic dendrites and renal podocytes. Synaptopodin-deficient (synpo–/–) mice lack dendritic spine apparatus display impaired activity-dependent long-term synaptic plasticity. In contrast, ultrastructure podocytes synpo–/– normal. Here we show that recovery from protamine sulfate–induced podocyte foot process (FP) effacement LPS-induced nephrotic syndrome. Similarly, actin...
The transcription factor NF-E2-related 2 (Nrf2) binds the antioxidant DNA response element (ARE) to activate important cellular cytoprotective defense systems. Recently several types of cancers have been shown overexpress Nrf2, but its role in radiation therapy has yet be fully determined. In this study, we report that single doses ionizing from 8 Gy ARE-dependent breast cancer cells a dose-dependent manner, only after delay five days. Clinically relevant daily dose fractions also increased...
Recent data indicate a hierarchical organization of many solid cancers, including breast cancer, with small number cancer initiating cells (CICs) that have the ability to self-renew and exhibit multi-lineage potency. We, others, demonstrated CICs in glioma are relatively resistant ionizing radiation if compared their non-tumorigenic counterparts. However, extent remaining self-renewing capacity after fractions is currently unknown. We hypothesized CICs, contrast counterparts, not only...
Abstract BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence differential addiction cells to anti-apoptotic BCL-2, BCL-X L or MCL-1, which correlated with respective protein expression ratio. ABT-263 (navitoclax), BCL-2/BCL-X inhibitor, prevented from sequestering activator BH3-only molecules (BH3s) BAX but not BAK. Consequently, failed kill -addicted low BH3s...
Purpose: PD-1/PD-L1 pathway inhibition is effective against advanced renal cell carcinoma, although results are variable and may depend on host factors, including the tumor microenvironment. Vascular-targeted photodynamic (VTP) therapy with photosensitizer WST11 induces a defined local immune response, we sought to determine whether this could potentiate systemic antitumor response PD-1 inhibition.Experimental Design: Using an orthotopic Renca murine model of carcinoma that develops lung...
Arctiin, isolated from Forsythia suspensa has been reported to have anti-inflammatory, anti-oxidant, antibacterial, and antiviral effects in vitro. However, there a lack of studies regarding its on immunological activity. The aim this study is investigate the anti-inflammatory potential possible mechanisms arctiin LPS-induced macrophages.We investigated mRNA protein levels proinflammatory cytokines through RT-PCR western blot analysis, followed by FACS analysis for surface molecule...
Recent development of flexible/stretchable integrated electronic sensors and stimulation systems has the potential to establish an important paradigm for implantable devices, where shapes mechanical properties are matched those biological tissues organs. Demonstrations tissue immune biocompatibility fundamental requirements application such kinds electronics long‐term use in body. Here, a comprehensive set experiments studies on four representative device platforms, selected basis their...
A vertically integrated junctionless field-effect transistor (VJ-FET), which is composed of stacked multiple silicon nanowires (SiNWs) with a gate-all-around (GAA) structure, demonstrated on bulk wafer for the first time. The proposed VJ-FET mitigates issues variability and fabrication complexity that are encountered in multi-NW FET (VM-FET) based an identical structure VM-FET, as recently reported, harnesses source drain (S/D) junction its operation thus inversion mode. Variability...
Abstract Cancers arising from the bladder urothelium often exhibit lineage plasticity with regions of urothelial carcinoma adjacent to or admixed divergent histomorphology, most commonly squamous differentiation. To define biologic basis for and clinical significance this morphologic heterogeneity, here we perform integrated genomic analyses mixed histology cancers separable We find that differentiation is a marker intratumoral immunologic heterogeneity in patients cancer biomarker intrinsic...
Indium phosphide (InP) quantum dots have enabled light-emitting diodes (LEDs) that are heavy-metal-free, narrow in emission linewidth, and physically flexible. However, ZnO/ZnMgO, the electron-transporting layer (ETL) high-performance red InP/ZnSe/ZnS LEDs, suffers from high defect densities, quenches luminescence when deposited on InP, induces performance degradation arises due to trap migration ETL InP emitting layer. We posited formation of Zn2+ traps outer ZnS shell, combined with sulfur...
Abstract Quantum dot (QD) light‐emitting diodes (QLEDs) are promising for next‐generation displays, but suffer from carrier imbalance arising lower hole injection compared to electron injection. A defect engineering strategy is reported tackle transport limitations in nickel oxide‐based inorganic hole‐injection layers (HILs) and find that able enhance high‐performance InP QLEDs using the newly designed material. Through optoelectronic simulations, how electronic properties of NiO x affect...
ABSTRACT Many strains of Pseudomonas syringae pv. produce one four classes small cyclic lipodepsinonapeptides: syringomycins, syringostatins, syringotoxins, or pseudomycins. These metabolites are phytotoxic and growth inhibitory against a broad spectrum fungi. Their production is dependent upon the expression conserved biosynthesis export genes syrB syrD , respectively. PCR oligonucleotide primers specific for 752-bp fragment were used to identify lipodepsinonapeptide-producing P. syringae....
Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, terrorist attacks is importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) regional and a major component the acute syndrome. The purpose this study was identify novel radioprotectors mitigators hematopoietic system.High-throughput screening small-molecule libraries done using viability...
Abstract Adoptive natural killer (NK) cell therapy may offer an effective treatment regimen for cancer patients whose disease is refractory to conventional therapy. NK cells can kill a wide range of tumor by patterned recognition target ligands. We hypothesized that targets sensitive lysis would drive vigorous expansion from human peripheral blood mononuclear (PBMC). Here, we provide the basis developing novel ex vivo process. By screening class I–negative or –mismatched lines identified...