A5002327424- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Cancer Genomics and Diagnostics
- Pregnancy and preeclampsia studies
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Gestational Diabetes Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- interferon and immune responses
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Congenital Heart Disease Studies
University of Alabama at Birmingham
2023-2025
Saitama Medical University
2017-2024
Social Insurance Saitama Chuo Hospital
2017-2024
The University of Tokyo
2024
Kobe City Medical Center General Hospital
2012-2024
Saitama Prefecture
2022-2023
International University of Health and Welfare
2023
National Cancer Center Hospital East
2021-2023
Chiba Cancer Center
2021-2023
Tohoku University
2013-2023
Anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancers can be effectively treated with an ALK tyrosine inhibitor (TKI) such as crizotinib, but the response magnitude and duration are heterogeneous. Several variants have been identified, few studies focused on effects of different efficacy crizotinib.Among 55 patients crizotinib initial ALK-TKI between January 2007 December 2014, we identified 35 tumor specimens that could evaluated for by reverse transcription...
BACKGROUND The secondary epidermal growth factor receptor (EGFR) mutation Thr790Met (T790M) accounts for approximately half of acquired resistances to EGFR‐tyrosine kinase inhibitor (TKI). Recent reports have demonstrated that the emergence T790M predicts a favorable prognosis and indolent progression. However, rebiopsy confirm status can be challenging due limited tissue availability procedural feasibility, little is known regarding differences among patients with or without mutation....
Mild exposure to ultraviolet (UV) radiation is also harmful and hazardous the skin often causes a photosensitivity disorder accompanied by sunburn. To understand action of UV on we performed microarray analysis isolate UV-sensitive genes. We show here that irradiation promoted sunburn downregulated filaggrin (Flg); fucoxanthin (FX) exerted protective effect. In vitro showed human dermal fibroblasts caused production intracellular reactive oxygen species (ROS) without cellular toxicity. ROS...
Tumor heterogeneity underlies resistance to tyrosine kinase inhibitors (TKI) in lung cancers harboring EGFR mutations. Previous evidence suggested that subsets of preexisting resistant cells are selected by EGFR-TKI treatment, or alternatively, diverse acquired mechanisms emerge from drug-tolerant persister (DTP) cells. Many studies have used bulk tumor specimens subcloned cell lines identify mechanism. However, intratumoral can result divergent responses therapies, requiring additional...
BACKGROUND Lung adenocarcinoma in the young is a rare entity, and oncogenic genetic alterations (GAs) clinical characteristics associated with this disease are poorly understood. Conversely, it has been demonstrated that age at diagnosis defines unique biology other cancers. For report, effects of on lung reported. METHODS The authors retrospectively screened 1746 consecutive patients who were diagnosed stage I through IV between 2009 2015 identified 81 aged 40 years or younger diagnosis....
Abstract Background Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such supraphysiologic oxygen, remain unclear. Results We show oxygen exposure neonatal mice, or direct intestinal organoids suppresses expression AMPs and alters composition. Oral supplementation prototypical AMP lysozyme hyperoxia-exposed mice reduced...
The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity prematurity. While microbiota significantly influences neonatal health, relationship between intestinal microbiome, particularly micro-eukaryotic members such as fungi and yeast, injury severity in newborns remains unknown. Here, we show fungal modulates hyperoxia-induced low birth weight premature...
A well-validated instrument that is simple to use needed assess health-related quality of life in patients with interstitial lung disease (ILD). The COPD assessment test (CAT) a recently introduced, short and questionnaire for patients, which shows good valid measurement properties. This study was conducted evaluate the validity CAT ILD.Patients ILD (n = 55) completed St. George's Respiratory Questionnaire (SGRQ). These also Medical Research Council (MRC) dyspnoea scale, Leicester Cough...
Abstract Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment Children’s Study, a large-scale epidemiological investigation, to elucidate possible link between SHS HDP risk. Data were obtained all-birth fixed datasets included information 104,062 fetuses their parents....
Radiotherapy (RT) plus immunotherapy is a promising modality; however, the therapeutic effects are insufficient, and molecular mechanism requires clarification to further develop combination therapies. Here, we found that RNA virus sensor pathway dominantly regulates cellular immune response in NSCLC ESCC cell lines. Notably, transposable elements (TEs), especially long terminal repeats (LTRs), functioned as key ligands for RIG-I, mTOR-LTR-RIG-I axis induced dendritic macrophage infiltration...
Fucoxanthin (FX) is a xanthophyll that contained abundantly in marine plants. The biological action of FX includes its antioxidant and anti-lipogenic activities, while the precise mechanisms on skin cells has not yet been clarified. current study examined effect comparison with tacrolimus (TAC) NC/Nga mice, which are an atopic dermatitis (AD) model. topical treatment dramatically ameliorated itching behavior over TAC treatment, was insufficient for improvement AD symptoms. In Nc/Nga or...
ABSTRACT The influenza virus neuraminidase H274Y substitution is a highly prevalent amino acid associated with resistance to the most heavily used drug, oseltamivir. Previous structural studies suggest that group specific 252 residue (Y252 in 1 and T252 2) might be key factor underlying resistance. However, has only been reported N1 subtypes, which indicates there must additional residues determine Furthermore, we found members of NA serotype N3 also possess Y252, raising question as whether...