A5079280347- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Anesthesia and Sedative Agents
- Gut microbiota and health
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Cancer survivorship and care
- Gastroesophageal reflux and treatments
- Health disparities and outcomes
- Respiratory and Cough-Related Research
- Voice and Speech Disorders
- Asthma and respiratory diseases
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- Renal and related cancers
- Pleural and Pulmonary Diseases
- Dysphagia Assessment and Management
- Cardiac Arrest and Resuscitation
- Palliative Care and End-of-Life Issues
Kobe University
2018-2024
Kobe University Hospital
2020-2024
Columbia University Irving Medical Center
2023
Kobe Institute Of Computing
2020-2022
National Institute of Biomedical Innovation, Health and Nutrition
2022
Obayashi (Japan)
2020-2021
Weatherford College
2020-2021
Juntendo University
2021
Yokohama City University
2021
National Confidential Enquiry into Patient Outcome and Death
2020
Immune checkpoint inhibitors (ICI) are a novel medication for non-small cell lung cancer (NSCLC). Recent reports indicated that baseline tumor size (BTS) relates to the efficacy of ICI therapy melanoma, but no study exists NSCLC. This aimed evaluate utility BTS therapy.Data from 58 patients diagnosed with NSCLC who underwent monotherapy, were retrospectively analyzed. Patients divided into two groups according (below 101 mm, above mm). The primary endpoint was progression-free survival (PFS)...
<h3>BACKGROUND:</h3> We evaluated the efficacy of high-flow nasal cannula (HFNC) therapy, a promising respiratory support method for acute hypoxemic failure (AHRF). <h3>METHODS:</h3> conducted retrospective single-center cohort study comparing periods before (June 2010 to May 2012) and after 2012 2014) HFNC introduction (pre- post-HFNC periods). During these periods, we retrieved cases AHRF treated with any (invasive ventilation, noninvasive ventilation [NIV], HFNC) compared in-hospital...
Abstract Objective evaluations of cough frequency are considered important for assessing the clinical state patients with respiratory diseases. However, monitors audio recordings rarely used in settings. Issues regarding privacy and background noise barriers to wide use these monitors; solve problems, we developed a novel automatic monitoring system combining triaxial accelerator stretchable strain sensor. Eleven healthy adult volunteers 10 were enrolled. The participants wore two devices 30...
Millions suffer from incurable lung diseases, and the donor shortage hampers organ transplants. Generating whole in conjunction with thymus is a significant milestone for transplantation because central to educate immune cells. Using lineage-tracing mice human pluripotent stem cell (PSC)-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed both mesenchyme epithelium formation. Interestingly, lineage-derived cells progressively increased occupied more...
Objectives : Several studies have reported that oropharyngeal myofunctional therapy (OMT) reduces the severity of obstructive sleep apnea (OSA). However, because OMT protocols are often complicated, they take time and effort to implement. The aim this study was determine therapeutic effect 8 weeks simple tongue strength training with a device.
The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of several diseases, including cancer. In this study, we examined relationship between lung cancer progression.Female never-smokers diagnosed with adenocarcinoma were consecutively enrolled May 2018 August 2019, fecal samples collected. Principal coordinate analyses performed using Bray-Curtis distance matrices to investigate effects clinical variables (age, body mass index,...
In this study, we aimed to examine the clinical value of pleural effusion (PE) biomarkers, soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (CYFRA 21–1) and carcinoembryonic antigen (CEA), utility combining chest computed tomography (CT) findings with these in diagnosing malignant mesothelioma (MPM). We conducted a retrospective cohort study single center. Consecutive patients undiagnosed effusions who underwent PE analysis between September 2014 August 2016 were reviewed....
Objective Non-HIV patients with pneumocystis pneumonia (PCP) have a poor prognosis. We aimed to evaluate the prognostic factors for in-hospital mortality in terms of clinical findings, including results bronchoalveolar lavage fluid (BALF)-analyses, non-HIV PCP patients. Methods retrospectively reviewed diagnosed using between April 2006 and July 2012. For respiratory status, noninvasive positive pressure ventilation (NPPV) was used during (BAL) procedure. Data regarding demographics,...
Data on prognosis and predictors of overall survival in advanced lung cancer patients diagnosed following emergency admission (DFEA) are currently lacking. We retrospectively analysed data from 771 with nonsmall cell between April 2004 2012. Of the patients, 103 (13%) were DFEA. DFEA was not an independent predictor by multivariate Cox proportional hazard models, whereas good performance status (PS), epidermal growth factor receptor gene mutation, stage IIIB, adenocarcinoma chemotherapy...
Patients frequently experience great discomfort during a bronchoscopy for the diagnosis of lung neoplasms. Sedation is generally recommended bronchoscopy; however, few studies have evaluated and tolerability patients to with regard administration procedures. The aim present study was evaluate undergoing using different sedation procedures midazolam. retrospective survey involved comparison two periods: January‑March 2012 (first period) July‑September (second period). A numerical rating...
Background/Aim: Previous reviews of Social determinants health in lung cancer patients have not examined essential factors such as social isolation and loneliness. This study aimed to explore the affecting loneliness among patients. Patients Methods: A cross-sectional was conducted. isolation, loneliness, presence dementia were measured using Japanese adaptations Lubben Network Scale, UCLA Loneliness Life Function Evaluation for Care Provision, respectively. Results: From March 2019 2020,...
The aim of this study was to identify factors affecting the final diagnosis cough.This recruited 463 consecutive patients who visited five Japanese general hospitals due cough from October 2006 September 2007. Of these, 418 (90%) completed a questionnaire designed acquire data regarding clinical manifestations were included.Most with bronchial asthma had seasonal variation and wheezing. Patients gastro esophageal reflux disease suffered heartburn without daily or variation. Cough associated...
Socioeconomic factors with an influence on human health are known as social determinants of (SDH). There some SDH studies in patients lung cancer, but important exposures such isolation and loneliness have not been adequately investigated. This study will assess the SDH, particularly loneliness, advanced cancer Japan.The inclusion criteria for this prospective cohort be follows: a diagnosis cancer; unsuitability curative surgery; willingness to participate. The primary outcome initial choice...
Background Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) useful diagnose peripheral lesions. The data of numbers obtained two different sizes GSs limited. We conducted this study investigate utility large GS kit obtain many cells in patients NSCLC. Methods Patients lesion and suspected NSCLC were prospectively enrolled. They underwent TBB...
Abstract Background Bronchoscopy can be a distress for the patient. There have been few studies on combination of sedatives and opioids. The aim this study was to demonstrate usefulness safety administration midazolam pethidine during bronchoscopy. Methods In prospective randomized single (patient)-blind study, we randomly assigned 100 patients who were scheduled undergo bronchoscopy biopsy receive treatment with either midazolam/pethidine (combination group) or alone (midazolam...
Aim: The aim of the present study was to assess prognostic utility pretreatment blood neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein-to-albumin (CAR) in patients with inoperable malignant pleural mesothelioma (MPM). Materials Methods: medical records consecutive histologically confirmed MPM from our hospital between January 2007 August 2017 were retrospectively reviewed. primary outcome overall survival (OS). Univariate multivariate analyses for factors performed using a Cox...