A5080797760- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Mathematical and Theoretical Epidemiology and Ecology Models
- Tissue Engineering and Regenerative Medicine
- Chaos control and synchronization
- Renal and related cancers
- Mathematical Biology Tumor Growth
- Occupational and environmental lung diseases
- Nonlinear Dynamics and Pattern Formation
- Congenital heart defects research
- Bacillus and Francisella bacterial research
- Bacterial biofilms and quorum sensing
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Mathematical Dynamics and Fractals
- Evolution and Genetic Dynamics
- Advanced Differential Equations and Dynamical Systems
- bioluminescence and chemiluminescence research
- Redox biology and oxidative stress
- Fractional Differential Equations Solutions
- Axon Guidance and Neuronal Signaling
- S100 Proteins and Annexins
Gauhati University
2013-2025
Columbia University Irving Medical Center
2022-2024
Indian Institute of Science Education and Research Kolkata
2024
Columbia University
2023-2024
New York Stem Cell Foundation
2023-2024
Showa University
2023
Okinawa Institute of Science and Technology Graduate University
2020
In this work, we present a mathematical framework that captures the dynamic behavior of simultaneous propagation two strains COVID-19. We apply next-generation matrix method to compute basic reproduction ratio $\mathscr{R}_{0}$ . investigate stability model at each feasible equilibria. To validate our theoretical results, have conducted numerical simulations. It is observed if $\mathscr{R}_{0} \leq 1$ , eventually there will be no disease. However, > competition between COVID-19 occur, and...
Millions suffer from incurable lung diseases, and the donor shortage hampers organ transplants. Generating whole in conjunction with thymus is a significant milestone for transplantation because central to educate immune cells. Using lineage-tracing mice human pluripotent stem cell (PSC)-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed both mesenchyme epithelium formation. Interestingly, lineage-derived cells progressively increased occupied more...
Primary fibroblasts are a precious resource in the field of translational regenerative medicine. Dermal derived from human subject biopsies being used as donor tissues for derivation patient-specific iPSC lines, which turn disease modeling, drug screening, tissue engineering, and cell transplantation. We developed fast simple protocol to grow dermal skin biopsies. Using this protocol, we simply firmly fix biopsy piece on surface culture-treated plate allow grow. This novel method eliminates...
In the present study, we developed a modified immune-tumor-normal cell model, considering Lotka-Volterra-type competitions between populations and chemotherapy drugs. The local stability of model has been examined at each equilibrium point. Also, global tumor-free looked at, range drug administration rates found for which state is asymptotically stable globally. growth tumor cells was kept to minimum by setting up an optimal control policy how drugs are given. We that strategy helped...
Summary Various patients suffer from dry mouth due to salivary gland dysfunction. Whole generation and transplantation is a potential therapy resolve this issue. However, the lineage permissible design entire has been enigmatic. Here, we discovered Foxa2 as critical for generating via conditional blastocyst complementation (CBC). linage, but not Shh nor Pitx2, initiated label between boundary region of endodermal ectodermal oral mucosa before primordial formation, resulting in marking gland....
Abstract Pigs are evolutionarily more distant from humans than mice, but their physiological organs closest to humans. The molecular program leading a 1,000-fold increase in organ size pigs and over that of mice across evolution has not been elucidated. We generated large-scale transcriptional landscapes throughout swine lung development. Our cross-species single-cell atlas let us discover progenitor identities, stage-specific markers, core organ-size regulation (COSRP), well-conserved less...
Summary Mesothelial cells, in the outermost layer of internal organs, are essential for both organ development and homeostasis. Although parietal mesothelial cell is primary origin mesothelioma that may highjack developmental signaling, signaling pathways orchestrate developing progenitor (MPC) behaviors, such as MPC pool expansion, maturation, differentiation, poorly understood. To address it, we established a robust protocol culturing WT1 + MPCs isolated from pig mouse thorax. Quantitative...
Bacteria have been known to thrive in challenging environmental niches through diverse phenomena. Swarming is one such favourable adaptation that could help bacteria survive extreme conditions. Therefore, targeting swarming crucial for improving our understanding of bacterial motility and preventing related infections. Bacillus cereus, which causes food poisoning, has shown perform swarming, salts like NaCl can act as a preservative control growth. In order explore the possible alterations...
Summary In the animal kingdom, evolutionarily conserved mechanisms known as cell competition eliminate unfit cells during development. Interestingly, also leads to apoptosis of donor upon direct contact with host from a different species interspecies chimera formation. The underlying how recognize and transmit death signals adjacent xenogeneic human remain incompletely understood. this study, we developed an reporter system dissect competitive interactions between mouse pluripotent stem...
Mesothelial cells, in the outermost layer of internal organs, are essential for both organ development and homeostasis. Although parietal mesothelial cell is primary origin mesothelioma that may highjack developmental signaling, signaling pathways orchestrate developing progenitor (MPC) behaviors, such as MPC pool expansion, maturation, differentiation, poorly understood. To address it, we established a robust protocol culturing WT1 + MPCs isolated from pig mouse thorax. Quantitative qPCR...
Abstract Millions suffer from incurable lung diseases, and the donor shortage hampers organ transplants. Identifying crucial lineage program for organogenesis could facilitate designing whole-lung bioengineering. Using lineage-tracing mice human iPSC-derived lung-directed differentiation, we revealed that gastrulating Foxa2 contributed to both mesenchyme epithelium formation. Interestingly, lineage-derived cells in progressively increased occupied more than half of niche, including...
Inthe present paper we have considered the map ) , ( 2 x b ay y W -+ =where are parameters.The was originally proposed by Maynard Smith [17] for study of population growth.We shown how chaos creep into model.We used techniques Lyapunov exponent, time series analysis, Fourier spectra, Bifurcation diagram, correlation and embedding dimension etc. to draw our conclusions.Further, 'periodic proportional pulse' method can be control generated in system.
Abstract The multi-subunit eukaryotic CCR4-NOT complex imparts gene expression control primarily via messenger RNA (mRNA) decay. Here, we present the role of subunit CNOT9 in target mRNA decay during embryonic development. null mice appear normal by onset gastrulation (E7.0), however, exhibit growth and differentiation defects accompanied extensive cell death day 9.5 (E9.5). Sox-2 Cre conditional knockout show almost identical phenotype with brief delay progression, suggesting to be...