A5102935808- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Renal and related cancers
- Maternal and fetal healthcare
- Organ Transplantation Techniques and Outcomes
- Medical Imaging and Pathology Studies
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Mechanical Circulatory Support Devices
- Pneumocystis jirovecii pneumonia detection and treatment
- DNA Repair Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Pluripotent Stem Cells Research
- Connective tissue disorders research
- S100 Proteins and Annexins
- Proteoglycans and glycosaminoglycans research
- Genetic factors in colorectal cancer
- Pregnancy-related medical research
- Renal Transplantation Outcomes and Treatments
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
Nagoya University
2014-2025
Okayama University
2020-2024
Columbia University Irving Medical Center
2023-2024
Okayama University Hospital
2021-2023
Akita University
2003-2023
Society of Thoracic Surgeons
2022
Aichi Gakuin University
2019-2022
Okayama Red Cross General Hospital
2020
Red Cross Hospital
2020
Akita University Hospital
2011-2020
Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) associated with increased risk for various cancers, particularly colorectal cancer endometrial (EC). Women LS account 2% to 6% of EC patients; it clinically important identify such individuals predicting and/or preventing additional LS-associated cancers. PMS2 (PMS2-LS) rarest contribution etiology among 4 MMR mutations, its...
Abstract Background Postoperative adjuvant chemotherapy using oxaliplatin in addition to 5-FU-based anticancer agents has become the standard treatment for colorectal cancer, however, there is insufficient evidence regarding efficacy and safety of combination therapy elderly patients. In this study, retrospective analysis results from CCOG-1302 study was performed confirm them. Methods The patients CAPOX continuous (8 courses CAPOX) intermittent (2 + 4 capecitabine 2 arms were divided into...
Millions suffer from incurable lung diseases, and the donor shortage hampers organ transplants. Generating whole in conjunction with thymus is a significant milestone for transplantation because central to educate immune cells. Using lineage-tracing mice human pluripotent stem cell (PSC)-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed both mesenchyme epithelium formation. Interestingly, lineage-derived cells progressively increased occupied more...
The aim of this study was to investigate neutrophil elastase (NE) in amniotic fluid as a potential marker for predicting pregnancy continuation.
Oral squamous cell carcinoma (OSCC) is the most frequently occurring cancer among head and neck SCC worldwide. The identification of novel effective biomarkers for early detection may greatly improve survival rate prognosis patients with OSCC. This study aimed to identify specific oral microbial profiles associated OSCC.Saliva samples were collected from leukoplakia (OLK) OSCC (N = 6 each) healthy controls (HC; N 4). Total bacterial genomic DNA was isolated 16S rRNA gene survey performed by...
Lung adenocarcinoma (LUAD) is the most common types among lung cancers generally arising from terminal airway and understanding of multistep carcinogenesis crucial to develop novel therapeutic strategy for LUAD. Here we used human induced pluripotent stem cells (hiPSCs) establish iHER2-hiPSCs in which doxycycline expression oncoprotein epidermal growth factor receptor 2 (HER2)/ERBB2. progenitors that differentiated iHER2-hiPSCs, expressed NKX2-1/TTF-1 known as a lineage maker, were...
Recently, the possibility that oral microbiomes is associated with squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association still unclear. Here, we comprehensively analyze microbiome profiles of saliva samples using next-generation sequencing followed by determining between OSCC.Microbiome in from patients OSCC, leukoplakia (OLK), postoperative OSCC (Post) were analyzed. Candidate OSCC-associated bacteria identified comparing bacterial...
During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers inflammatory responses. We assessed the therapeutic effect of neutralizing anti-HMGB1 monoclonal antibody (mAb) on lung IR injury. A murine hilar clamp model was used, where mice were divided into sham groups with intravenous administration anti-HMGB mAb or control mAb. analyzed against injury by assessing oxygenation, score, neutrophil...
Abstract Introduction We report herein a new method of transumbilical laparoscopic surgery using G el P ort through an umbilical zigzag skin incision. The involves collaborating with plastic surgeons to ensure the procedure was minimally invasive. Materials and Surgical Technique After marking incision in region, incised along this line. Then, double‐ring wound retractor inserted incision, which enlarged diameter fascial opening 6 cm. p latched on ring, following inflation pneumoperitoneum...
Abstract A cervical varix during pregnancy is a very rare complication. It can lead to hemorrhage and may result in significant morbidity. Furthermore, appropriate management has not yet been established. We present case of with placenta previa totalis. 30‐year‐old woman totalis also had without bleeding. At 32 weeks' gestation, massive from the occurred. vaginal pack controlled bleeding, cesarean section was subsequently carried out because uncontrollable uterine contractions. 1655 g female...
Abstract Background Large type 3 (diameter ≥ 8 cm) and 4 gastric cancers have been arbitrarily combined in Japan as a single entity. However, whether these two types are oncologically similar remain unclear. This study aimed to clarify this issue. Methods In retrospective study, we analyzed database of 3,575 patients from nine institutions who underwent gastrectomy between 2010 2014. Using propensity scores balance significant variables, compared prognoses tumor recurrences. Results Of with...
Introduction Autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) is rare compared with other forms of and characterized by cardiac conduction defects. Here, we present the case a patient diagnosed AD-EDMD during first trimester pregnancy who developed acute preeclampsia subsequently, congestive heart failure (CHF) following cesarean section. Case A 36-year-old, gravida 0 para woman was genetic testing pregnancy, she suddenly partial HELLP (hemolytic anemia, elevated liver enzymes,...
(1) Background: Lung ischemia–reperfusion (IR) injury increases the mortality and morbidity of patients undergoing lung transplantation. The objective this study was to identify key initiator IR evaluate pharmacological therapeutic approaches using a functional inhibitor against identified molecule. (2) Methods: Using mouse hilar clamp model, combination RNA sequencing histological investigations revealed that neutrophil-derived S100A8/A9 plays central role in inflammatory reactions during...
Abstract Pulmonary alveolar proteinosis (PAP) affecting transplanted lungs is not well recognized. Herein, we report two cases of PAP after lung transplantation (LTx). The first case was a 4‐year‐old boy with hereditary pulmonary fibrosis who underwent bilateral LTx and presented respiratory distress on postoperative day (POD) 23. He initially treated for acute rejection, died due to infection POD 248, diagnosed at autopsy. second involved 52‐year‐old man idiopathic LTx. On 99, chest...
Summary Various patients suffer from dry mouth due to salivary gland dysfunction. Whole generation and transplantation is a potential therapy resolve this issue. However, the lineage permissible design entire has been enigmatic. Here, we discovered Foxa2 as critical for generating via conditional blastocyst complementation (CBC). linage, but not Shh nor Pitx2, initiated label between boundary region of endodermal ectodermal oral mucosa before primordial formation, resulting in marking gland....
Abstract An extragonadal yolk sac tumor (YST) is a rare malignant germ cell that usually occurs in childhood. The pathogenesis of YST remains largely unknown, especially with regards to its origin. Herein, we report case arising the uterine round ligament. A 31‐year‐old Japanese woman, para 2, underwent partial resection left‐sided, 5‐cm, solid inguinal mass. Intraoperative findings showed enlargement ligament canal. Pathological evaluation diagnosed mass as mature teratoma (MT) component....
We report a case of cesarean section by transfundal vertical incision for placenta previa percreta attached to the anterior uterine wall in woman with previous repeated delivery. This approach is useful procedure such cases. discuss effectiveness and incision. A 33-year-old pregnant Japanese was referred our hospital perinatal management. She 28 weeks into her 7th pregnancy, having had four spontaneous miscarriages at 26, 27, 30 years age two sections 32 years. Both were performed because...