A5071231818- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Soft tissue tumors and treatment
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Oral microbiology and periodontitis research
- Dysphagia Assessment and Management
- S100 Proteins and Annexins
- Periodontal Regeneration and Treatments
- Craniofacial Disorders and Treatments
- Cancer Cells and Metastasis
- Bone and Dental Protein Studies
- Nicotinic Acetylcholine Receptors Study
- Molecular Biology Techniques and Applications
- Kruppel-like factors research
Aichi Gakuin University
2014-2024
Creative Commons
2024
Nagoya City University
2006-2012
Active Implants (United States)
2009
Kyoto University
1996
Abstract Purpose: Mucoepidermoid carcinoma is the most common primary malignancy of salivary gland. translocated gene 1-mastermind-like family (MECT1-MAML2) fusion was identified from a recurring t(11;19)(q21;p13) translocation, which often sole cytogenetic alteration in this disease. This transcript has been frequently detected mucoepidermoid and shown to be involved transformation epithelial cells. However, its clinicopathologic significance remains unclear. Experimental Design:...
Mammary analogue secretory carcinoma (MASC) is a recently described low-grade with morphologic and genetic similarity, including ETV6-NTRK3 fusion, to of the breast. ETV6 frequently involved in other epithelial nonepithelial tumors, many fusion partners have been reported. In present study, 14 Japanese MASC cases were clinicopathologically molecularly analyzed. The median age patients was 39 years, male:female ratio 6:8. All showed histopathologic findings compatible those previously for...
The purpose of this study was to determine prognostic factors for the recurrence keratocystic odontogenic tumors (KCOTs) following simple enucleation by examining clinico-pathologic and immunohistochemical findings.Following enucleation, frequency among 32 subjects diagnosed with KCOT analyzed tumor site, radiographic histologic features, immunopositivity Ki-67 p53.Keratocystic in four out (12.5%) recurred during follow-up period (median: 33 months, range: 7-114 months). Three (75.0%)...
Okumura Y, Miyabe S, Nakayama T, Fujiyoshi Hattori H, Shimozato K & Inagaki H(2011) Histopathology59, 90–97 Impact of CRTC1/3–MAML2 fusions on histological classification and prognosis mucoepidermoid carcinoma Aims: The aim study was to evaluate the impact CRTC1–MAML2 CRTC3–MAML2 (MEC) salivary glands patients. Methods results: MEC cases (n = 111) were screened for by reverse transcription polymerase chain reaction. We developed a system 'molecular Armed Forces Institute Pathology (AFIP)...
CRTC1-MAML2 and CRTC3-MAML2 fusions have been associated with favorable clinicopathological features of mucoepidermoid carcinomas. However, the significance MAML2 gene split has not fully clarified. In present study, 95 carcinomas (paraffin-embedded materials) were analyzed for by RT-PCR FISH. Quantitative transcript was performed in selected cases. MLL involvement, which reported some leukemia cases, examined FISH fusion partner-unknown detected 37 6 respectively. The 62 included all...
Abstract Immunotherapy with immune‐checkpoint therapy has recently been used to treat oral squamous cell carcinomas (OSCCs). However, improvements in current immunotherapy are expected because response rates limited. Transforming growth factor‐β (TGF‐β) creates an immunosuppressive tumor microenvironment (TME) by inducing the production of regulatory T‐cells (Tregs) and cancer‐associated fibroblasts inhibiting function cytotoxic T‐lymphocytes (CTLs) natural killer cells. TGF‐β may be...
Oral squamous cell carcinoma (OSCC) is the most frequently occurring cancer among head and neck SCC worldwide. The identification of novel effective biomarkers for early detection may greatly improve survival rate prognosis patients with OSCC. This study aimed to identify specific oral microbial profiles associated OSCC.Saliva samples were collected from leukoplakia (OLK) OSCC (N = 6 each) healthy controls (HC; N 4). Total bacterial genomic DNA was isolated 16S rRNA gene survey performed by...
Recently, the possibility that oral microbiomes is associated with squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association still unclear. Here, we comprehensively analyze microbiome profiles of saliva samples using next-generation sequencing followed by determining between OSCC.Microbiome in from patients OSCC, leukoplakia (OLK), postoperative OSCC (Post) were analyzed. Candidate OSCC-associated bacteria identified comparing bacterial...
Oral cancer may become advanced because of delay in diagnosis. In order to promote oral screening, simple and highly reliable screening methods that can be implemented at general dental clinics are required. Herein we investigated differential salivary gene expression between squamous cell carcinoma (OSCC) patients healthy volunteers (HV) identify new biomarkers for OSCC detection.Candidate genes were selected by microarrays, nuclear undecaprenyl pyrophosphate synthase 1 (NUS1)...
This study aimed to elucidate the oral hygiene status and factors associated with poor among patients schizophrenia.The relationships of (calculus index [CI], debris [DI]), mean number decayed-missing-filled teeth (mean DMFT), Revised Oral Assessment Guide (ROAG) related (hospitalization, chlorpromazine equivalents [CPZE], age, Barthel Index [BI], frequency cleaning teeth, self-oral ability) 249 hospitalized schizophrenic were investigated.The results for as follows: median (range); CI 0.5...
The OSR (oxidative-stress-resistance) gene was cloned as the which enhances resistance against oxidative stress caused by lipid hydroperoxide in Saccharomyces cerevisiae. nucleotide sequence of determined and found to be identical with zinc-resistance-conferring (ZRCI) gene, enhancing zinc cadmium. A knockout mutant showed increased sensitivity hydroperoxide. intracellular glutathione content decreased approx. 40% compared that wild-type cells, whereas it 3-fold yeast overexpressing gene....
Background: Clinicopathological studies have revealed some distinct anatomical variations in the clinical presentation of oral leukoplakia (OL). Screening shown that gingival (GL) to be more common among Japanese. Objective: A hospital-based case-control study was undertaken patients diagnosed with OL compare clinico-pathological data between GL and affecting other sites (n-GL). Methods: One hundred fifty-one subjects attending four city hospitals Japan were recruited this study. by World...
Background We performed a randomized controlled chemoprevention trial of oral leukoplakia by administrating low dose beta‐carotene and vitamin C supplements. 17% subjects in the experimental arm (4/23) demonstrated clinical remission (complete or partial response) at completion trial. The objective this study was to determine whether baseline expression p53 ki67 any differences between those responding not our intervention. A secondary elucidate relationship dietary factors responses....
The expression of programmed death ligand-1 (PD-L1) is controlled by complex mechanisms. elucidation the molecular mechanisms PD-L1 important for exploration new insights into PD-1 blockade therapy. Detailed in situ tissues oral squamous cell carcinomas (OSCCs) have not yet been clarified. We examined focusing on phosphorylation downstream molecules epidermal growth factor (EGF) and interferon gamma (IFN-γ) signaling vitro vivo immunoblotting multi-fluorescence immunohistochemistry (MF-IHC),...
Odontogenic keratocyst (OKC) is the third most common odontogenic cyst which arises from cell rests of dental lamina, and usually observed in jaws. Because OKC noted for its high rate recurrence, there are various treatment strategies. Here, we present a rare case occupied entire maxillary sinus pterygoid process sphenoid bone extending nearly to skull base. The patient was 21-year-old male underwent surgical removal using Caldwell-Luc procedure this extended approach via pterygomaxillary...
1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Tobacco smoke and involuntary smoking. International Agency for Research Cancer; 2004. Monographs Humans; vol. 83. Accessed April 22, 2022. https://www.ncbi.nlm.nih.gov/b... Google Scholar
Atherosclerosis is a major cause of mortality worldwide. The initial change in atherosclerosis intimal thickening due to muscle cell proliferation and migration. A correlation has been observed between periodontal disease atherosclerosis. Here, we investigated the migration human aortic smooth cells (HASMCs) using Porphyromonas gingivalis-derived LPS (Pg-LPS). To elucidate intracellular signaling, toll-like receptor 4 (TLR4) myeloid differentiation factor 88 (MyD88) HASMCs were knocked down,...
Aims: To evaluate proliferation and apoptosis in high‐grade sarcomas of the extremities before after preoperative radio‐hyperthermo‐chemotherapy (RHC) to determine relationship between these parameters treatment outcomes. Methods results: Pre‐ post‐RHC specimens 41 soft tissue bone tumours were immunohistochemically stained for minichromosome maintenance protein (MCM) 2 caspase 3 as markers, respectively, based on a preliminary study comparing them with conventional markers. Indices...
Polymorphous adenocarcinoma is a common intraoral minor salivary gland carcinoma in Western countries but extremely rare Japan. The current study aimed to characterize the clinicopathological features and status of molecular alterations polymorphous adenocarcinoma-associated genes, such as PRKD1/2/3, ARID1A, DDX3X, large cohort Japanese patients with adenocarcinoma.We examined cases 36 26 involving histopathological mimics. To detect gene splits, fluorescence situ hybridization was carried...
Abstract IgG4‐related sclerosing sialadenitis is currently considered as an autoimmune disease distinct from Sjogren’s syndrome (SS) and responds extremely well to steroid therapy. To further elucidate the characteristics of sialadenitis, we analysed VH fragments IgH genes their somatic hypermutation in SS ( n = 3) 3), using sialolithiasis a non‐autoimmune control. DNA was extracted affected inflammatory lesions. After PCR amplification rearranged genes, at least 50 clones per case (more...
Abstract Objective Oral leukoplakia is keratinized lesions in the buccal mucosa, tongue, and gingiva. It most common oral precancerous lesion; oxidative stresses irrelevant autophagy have been reported to be cause of oncogenesis. p62, a cytoplasmic protein induced by stress, an adaptor involved formation aggregates induction inhibition autophagy. The induces p62 overexpression promotes oncogenesis via oncogenic signaling pathway. aim present study was elucidate involvement intracellular...