A5012443552- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Dental Radiography and Imaging
- Head and Neck Surgical Oncology
- Temporomandibular Joint Disorders
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Bone health and treatments
- Bone Tumor Diagnosis and Treatments
- Oral health in cancer treatment
- Bone and Joint Diseases
- Dental Implant Techniques and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Tumors and Oncological Cases
- Ear and Head Tumors
- Traumatic Ocular and Foreign Body Injuries
- Oral and gingival health research
- Cancer-related Molecular Pathways
- Bone Tissue Engineering Materials
- Orthodontics and Dentofacial Orthopedics
- Cleft Lip and Palate Research
- Facial Nerve Paralysis Treatment and Research
Nara Medical University
2016-2025
Japan Cancer Society
2023-2024
Nara Medical University Hospital
1999-2023
Rakuwakai Otowa Hospital
2023
National Medical Research Center of Dentistry and Maxillofacial Surgery
2001-2021
Japanese Society of Medical Oncology
2021
National Archives and Records Administration
2013-2020
Creative Commons
2019
Shinshu University
2017
American Society of Clinical Oncology
2012
ABSTRACT Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit treatment primary disease and remarkably influence patient's quality life. The methods for MRONJ, nonsurgical surgical, are controversial, with no agreement as to which method provides best outcome should therefore be recommended. This multicenter retrospective study aimed investigate in a large number patients MRONJ Japan, utilizing propensity score matching analysis. A total 361 at eight...
MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain (EGFL7). However, the role miR-126 in cancer controversial.We examined function oral squamous cell carcinoma (OSCC) cells. Furthermore, a series 118 cases with OSCC were evaluated for expression levels miR-126.MicroRNA-126 was associated and regulation vascular endothelial factor-A activity, demethylation treatment increased EGFL7 A significant association found...
Abstract Background: The incidence of delayed neck metastasis (DNM) in patients with squamous cell carcinoma (SCC) the tongue is reported to be 20% 50%. Although clinically negative cervical lymph nodes (N0) are associated a good outcome, prognosis poor DNM. aim this study was evaluate clinicopathological and immunohistochemical parameters DNM stage I/II SCC. Methods: Fifty nine patients, previously untreated carcinoma, underwent examination A linear discriminant analysis used analyze...
Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from host immune system response. Here, we attempted elucidate role programmed death ligand 1 (PD-L1), microenvironment, and mechanisms that allow malignant transformation oral precancerous lesions. Patients with lesions managed at Nara Medical University Hospital, Japan, (n = 120) were enrolled in this study. Epithelial dysplasias graded by experienced pathologists, subepithelial...
The purpose of this study was to investigate the biomechanical behavior immediately loaded implants in an edentulous mandible according "All-on-Four" concept.A 3D-finite element model constructed. Four were placed between bilateral mental foramen concept. A framework made titanium or acrylic resin first molars modeled. Immediate loading and a delayed protocol simulated. vertical load 200N applied at cantilever on abutments region distal implants, simulating absence cantilever.The peak...
Abstract A multi‐institutional study was undertaken to determine whether mandibular canal ( MC ) invasion and medullary bone are independent factors in lower gingival squamous cell carcinoma SCC ). total of 345 patients with were retrospectively reviewed. Mandibular categorized into three types; no invasion; through cortical (medullary); invasion. The overall survival rate affecting local, regional, distant failures assessed by Cox proportional hazards regression analysis Kaplan–Meier...
Lower third molar extraction is the most common surgical treatment among routine dental and oral procedures. while procedures for lower are well established, difficulty of tooth frequency postoperative complications differ depending on patient’s background. To establish a management protocol molars, prevalence risk factors after were investigated in large number Japanese patients multicenter prospective study. During 6 consecutive months 2020, 1826 extractions performed at 20 participating...
Abstract Bisphosphonate-related osteonecrosis of the jaw (BRONJ), characterized by persistent bone exposure, is believed to result from inhibition remodeling and wound healing, often associated with potent intravenous bisphosphonates such as zoledronic acid (ZA). These are known significantly impact healing soft tissues due their anti-angiogenic properties. Our study aimed explore whether applying basic fibroblast growth factor (bFGF), for its ability promote angiogenesis remodeling, over...
Melanoma inhibitory activity (MIA) is an 11-kDa secretory protein isolated from malignant melanoma cells that correlated with invasion and metastasis in various human malignancies. We examined MIA expression 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. was significantly associated nodal (P = 0.00018). also of high mobility group box-1 (HMGB1) < 0.0001) lymph vessel density 0.0001). Expression levels MIA, HMGB1, nuclear factor kB (NFkB) p65 HMGB1-NFkB binding were higher a...
Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role function of Prox1 FOXC2 in cancer remains controversial. In present study, we examined expression proteins specimens from 163 cases with oral squamous cell carcinoma (OSCC). Furthermore, growth invasion was evaluated cultured OSCC cells. significantly associated local progression tumor (P = 0.0023), clinical stage (P<0.0001), lymphovessel density (LVD) nodal...
The expression of glucocorticoid receptors (GRs) was investigated immunohistochemically in two different lineages oligodendrocytes, using carbonic anhydrase (CA) II and neuron glial antigen (NG) 2 as markers mature oligodendrocytes oligodendrocyte progenitors, respectively. We focused on the gray matter regions, including CA1, CA3 dentate gyrus hippocampus, primary somatosensory cortex barrel field basolateral amygdala, white corpus callosum, external capsule fimbria hippocampus. More than...
Purpose: This study investigated the effects of bone density and crestal cortical thickness at implant-placement site on micromotion (relative displacement between implant bone) peri-implant strain distribution under immediate-loading conditions.Methods: A three-dimensional finite element model posterior mandible with an was constructed.Various parameters were simulated, including low or high cancellous density, thicknesses ranging from 0.5 to 2.5 mm.Delayed-and conditions simulated.A...
Objective The effect of direct oral anticoagulants (DOACs) on the risk bleeding after tooth extraction remains unclear. This study aimed to evaluate incidence postextraction among patients who received DOAC and vitamin K antagonists (VKAs), such as warfarin. Design was a retrospective cohort analysis. Incidence rates propensity score-matched regression models were used compare risks extractions involving DOACs VKAs. Setting took place in single university hospital Japan. Participants Between...