A5044432222- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cell Adhesion Molecules Research
- Brain Metastases and Treatment
- Signaling Pathways in Disease
- Heat shock proteins research
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Foot and Ankle Surgery
- Vascular Malformations Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Tendon Structure and Treatment
- Head and Neck Cancer Studies
- Protease and Inhibitor Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- FOXO transcription factor regulation
- Lower Extremity Biomechanics and Pathologies
- Spinal Fractures and Fixation Techniques
- Radiation Therapy and Dosimetry
Yokohama City University
2002-2025
Kobe University
2000-2025
Yokohama City University Medical Center
2024
Saitama International Medical Center
2015-2024
Saitama Medical University
2015-2024
Kōchi University
2015-2024
National Center for Global Health and Medicine
2024
University of Pittsburgh
2023-2024
University of Pittsburgh Medical Center
2023-2024
National Defense Medical College
2023-2024
We examined the influence of ROS on phosphorylation and complex formation Bcl‐2 family proteins in Mn‐superoxide dis‐mutase (SOD) antisense‐transfected squamous cell carcinoma cells, OSC‐4 cells. The increase intracellular level induced by cis ‐diamminedichloroplatinum (CDDP) γ‐ray treatment was greater cells than control vector‐trans‐fected apoptosis more extensively former. Antisense‐transfected expressed high levels Bax Bak, but low Bcl‐X L when treated with CDDP, peplomycin,...
OBJECTIVE The aim of this study was to reappraise long-term treatment outcomes stereotactic radiosurgery (SRS) for vestibular schwannomas (VSs). authors used a database that included patients who underwent SRS with unique dose-planning technique, i.e., partial tumor coverage designed avoid excess irradiation the facial and cochlear nerves, focusing on control hearing preservation. Clinical factors associated post-SRS preservation were also analyzed. METHODS This institutional review...
The most abundant green tea polyphenol, epigallocatechin-3-gallate (EGCG), was found to induce differential effects between tumor cells and normal cells. Nevertheless, how epithelial respond the polyphenol at concentrations for which undergo apoptosis is undefined. current study tested exponentially growing aged primary human epidermal keratinocytes in response EGCG or a mixture of four major polyphenols. elicited cell differentiation with associated induction p57/KIP2 within 24 h...
Green tea polyphenols (GTPPs) are considered beneficial to human health, especially as chemopreventive agents. Recently, cytotoxic reactive oxygen species (ROS) were identified in tumor and certain normal cell cultures incubated with high concentrations of the most abundant GTPP, (–)-epigallocatechin-3-gallate (EGCG). If EGCG also provokes production ROS epithelial cells, it may preclude topical use at higher doses. The current study examined oxidative status epithelial, salivary gland, oral...
The prevalence of diabetes mellitus (DM) in odontogenic infections and oral candidiasis was examined, influences DM on the clinical manifestations neutrophil functions were investigated. Among 21 severe 221 mild infections. detected 5 cases each group. Of 64 symptomatic candidiasis, 8 complicated with which by blood examination during treatment. During period infection, mean fasting sugar level 16.0 ± 4.4 9.8 1.2 minol/l DM‐complicated respectively. All white counts. C‐reactive protein...
The transcriptional factor hypoxia‐inducible factor‐1 (HIF‐1) plays an important role in solid tumor cell growth and survival. Overexpression of HIF‐1α has been demonstrated many human tumors predicts a poor response to chemoradiotherapy. We examined the HIF‐1α‐induced survival pathways oral squamous carcinoma (OSCC) lines. results showed that forced expression suppressed hypoxia‐induced apoptosis OSCC lines by inhibiting cytochrome c release from mitochondria. inhibited generation reactive...
Exosomes are 30–100 nm-sized membranous vesicles, secreted from a variety of cell types into their surrounding extracellular space. Various exosome components including lipids, proteins, and nucleic acids transferred to recipient cells affect function activity. Numerous studies have showed that tumor cell-derived exosomes play important roles in growth progression. However, the effect released oral squamous carcinoma (OSCC) microenvironment remains unclear. In present study, we isolated OSCC...
Cytokine generation by tissue‐infiltrating mononuclear cells (TIMC) and keratinocytes (KC) was investigated in material obtained from the oral mucosal tissues of patients with lichen planus (OLP). Peripheral blood (PBMC) chronically inflamed noninflamed gingival KC (CIG‐KC, NOR‐KC, respectively) were used as controls. Compared to NOR‐KC CIG‐KC, OLP (OLP‐KC) produced much more interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α) granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)....
The green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) possesses promising anticancer potential. Although in vivo studies unveiled the metabolic routes and pharmacokinetics of EGCG showed no adverse effects, vitro at high concentrations demonstrated oxidative stress. causes differential environments tumor versus normal epithelial cells, but roles that EGCG, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), intracellular catalase play system are largely unknown. current study employed...
Abstract The transcription factor hypoxia‐inducible factor‐1α (HIF‐1α) is the key regulator that controls hypoxic response of mammalian cells. overexpression HIF‐1α has been demonstrated in many human tumors. However, role therapeutic efficacy chemotherapy and radiotherapy cancer cells poorly understood. In this study, we investigated influence expression on susceptibility oral squamous cell carcinoma (OSCC) to chemotherapeutic drugs ( cis ‐diamminedichloroplatinum 5‐fluorouracil) γ‐rays....
A pilot study was performed to investigate the safety and feasibility of autologous formalin‐fixed tumor vaccines (AFTV) clinical responses these by glioblastoma multiforme (GBM) patients. Twelve primary GBM patients were recruited. Eight had recurrent disease while four been treated for but retained a visible mass. AFTV prepared from and/or paraffin‐embedded tissue obtained upon surgery premixed with original adjuvant materials. The given three five‐site intradermal inoculations at weekly...
Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and vivo effects of HDACIs, valproic acid (VPA), were investigated glioma the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to at optimum concentration a dose-dependent manner. reduced vascular growth factor (VEGF) secretion cells manner under both normoxic hypoxic conditions....
Temozolomide (TMZ) may enhance antitumor immunity in patients with glioblastoma multiforme (GBM). In this paper the authors report on a prospective Phase I/IIa clinical trial of fractionated radiotherapy (FRT) concomitant TMZ therapy, followed by treatment autologous formalin-fixed tumor vaccine (AFTV) and maintenance newly diagnosed GBM.Twenty-four (age 16-75 years, Karnofsky Performance Scale score ≥ 60% before initiation FRT) GBM received total dose 60 Gy FRT daily concurrent TMZ. After...
Carmustine (BCNU) implants (Gliadel® Wafer, Eisai Inc., New Jersey, USA) for the treatment of malignant gliomas (MGs) were shown to enhance overall survival in comparison placebo controlled clinical trials United States and Europe. A prospective, multicenter phase I/II study involving Japanese patients with MGs was performed evaluate efficacy, safety, pharmacokinetics BCNU implants. The enrolled 16 newly diagnosed 8 recurrent MGs. After insertion (8 sheets maximum, 61.6 mg BCNU) into removal...