A5076347170- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Facial Trauma and Fracture Management
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Bone and Dental Protein Studies
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Dental Radiography and Imaging
- Craniofacial Disorders and Treatments
- Oral and Maxillofacial Pathology
- Dental Implant Techniques and Outcomes
- Cleft Lip and Palate Research
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Oral microbiology and periodontitis research
- Adipose Tissue and Metabolism
- Facial Nerve Paralysis Treatment and Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Image and Video Retrieval Techniques
Sichuan University
2016-2025
Huazhong University of Science and Technology
2019-2025
Tongji Hospital
2019-2025
Chinese People's Liberation Army
2007-2025
Chongqing Medical University
2024-2025
Children's Hospital of Chongqing Medical University
2024-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
First Hospital of Jilin University
2025
Jilin University
2025
Purdue University West Lafayette
1996-2025
Automated annotation of protein function is challenging. As the number sequenced genomes rapidly grows, overwhelming majority products can only be annotated computationally. If computational predictions are to relied upon, it crucial that accuracy these methods high. Here we report results from first large-scale community-based critical assessment (CAFA) experiment. Fifty-four representing state art for prediction were evaluated on a target set 866 proteins 11 organisms. Two findings stand...
In this paper, we present a method for computing the resistance of molecular wires and illustrate it with systematic theoretical study particular class organic molecules. These molecules consist one or more benzene rings thiol(-SH) group at ends. This end can attach readily to metallic surfaces, thus allowing molecule function as nanoelectronic interconnect. The conduction through these low bias occurs by tunneling, leading resistances that are typically several tens megaohms. goes up...
Abstract Background The interaction between astrocytes and microglia plays a vital role in the damage repair of brain lesions due to traumatic injury (TBI). Recent studies have shown that exosomes act as potent mediators involved intercellular communication. Methods In current study, expression inflammatory factors miR-873a-5p lesion area oedema was evaluated 15 patients with injury. Exosomes secreted by were detected immunofluorescence, Western blot electron microscopy. A mouse model TBI an...
The Qingjiang River Basin, which is 423 km long in the Hubei province, China, first large tributary of Yangtze below Three Gorges. Basin surface water area monitoring plays an important role resource management strategy and regular watershed. Hydropower cascade exploitation, started 1987, has formed three reservoirs including Geheyan reservoir, Gaobazhou Shuibuya reservoir midstream downstream Basin. They have made a great impact on changes need to be taken into account. We monitor from 1973...
Bone marrow mesenchymal stem cell-derived small extracellular vesicles (BMSC-sEVs) can be used as a potential cell-free strategy for periodontal tissue regeneration, and we aim to investigate the effect possible mechanism of BMSC-sEV in regeneration this study. The was isolated by Exosome Isolation™ reagent identified transmission electron microscopy, nanoparticle tracking analysis, Western blotting. human ligament cells (hPDLCs) were cocultured with vitro detect effects on hPDLC migration,...
Adipose tissue is an active endocrine organ that can secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition soluble proteins in adipose tissue, microRNAs (miRNAs) enriched extracellular vesicles (EVs), such as exosomes or microvesicles, could modulate intercellular communications. this study, we demonstrated exosome-like derived from (Exo-AT) were internalized by tissue-derived stem cells (ADSCs), and these, turn, induced adipogenesis. High-throughput...
A stem cell-mediated bioengineered tooth root (bio-root) has proven to be a prospective tool for the treatment of loss.As shown in our previous studies, dental follicle cells (DFCs) are suitable seeding construction bio-roots.However, DFCs which can only obtained from unerupted germ restricted.Stem human exfoliated deciduous teeth (SHEDs), harvested much more easily through minimally invasive procedure, may used as an alternative cell.In this case, we compared odontogenic characteristics and...
Abstract Poor fiber orientation and mismatched bone–ligament interface fusion have plagued the regeneration of periodontal defects by cell‐based scaffolds. A 3D bioprinted biomimetic module is designed with high architectural integrity using a methacrylate gelatin/decellularized extracellular matrix (GelMA/dECM) cell‐laden bioink. The presents favorable mechanical properties guidance high‐precision topographical cues provides biochemical environment conducive to regulating encapsulated cell...
Lipopolysaccharide (LPS) pretreatment can enhance the therapeutic effect of dental follicle stem cells-derived small extracellular vesicles (DFC-sEV) for periodontitis, and this study aimed to investigate underlying mechanisms clinical application Of LPS-preconditioned DFC-sEV in periodontitis.The protein spectrum before after LPS was determined by liquid chromatography-tandem mass spectrometry bioinformatic analysis. Their effects on inflammatory periodontal ligament cells (PDLSCs)...
Bone defect caused by trauma, neoplasia, congenital defects, or periodontal disease is a major cause of disability and physical limitation. The transplantation bone marrow mesenchymal stem cells (BMSCs) promotes repair regeneration. However, it has been shown that most BMSCs die within short period after transplantation. During apoptosis, generate large number apoptotic cell–derived extracellular vesicles (ApoEVs). This study aims to understand the potential role ApoEVs in craniofacial...
Abstract Apoptosis releases numerous apoptotic vesicles that regulate processes such as cell proliferation, immunity, and tissue regeneration repair. Now, it has also emerged an attractive candidate for biotherapeutics. However, encompass a diverse range of subtypes, remains unclear which specific subtypes play pivotal role. In this study, we successfully isolated different vesicle based on their sizes characterized them using NTA TEM techniques, respectively. We compared the functional...
Compared with long bone that arises from the mesoderm, major portion of maxillofacial bones and front skull are derived cranial neural crest cells undergo intramembranous ossification. Human skeletal stem have been identified in embryonic fetal bones. Here, we describe a single-cell atlas human mandible identify population cranio-maxillofacial (CMSSCs). These CMSSCs marked by interferon-induced transmembrane protein 5 (IFITM5) specifically located around periosteum jawbone frontal bone....