A5102790769- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Periodontal Regeneration and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease and Spinal Disorders
- Telomeres, Telomerase, and Senescence
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Sleep and related disorders
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Wound Healing and Treatments
- Protease and Inhibitor Mechanisms
- Cardiovascular Health and Disease Prevention
- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Neuroscience of respiration and sleep
- Diabetic Foot Ulcer Assessment and Management
- Advanced biosensing and bioanalysis techniques
- Biomarkers in Disease Mechanisms
- Connective Tissue Growth Factor Research
Sichuan University
2007-2025
West China Hospital of Sichuan University
2025
State Key Laboratory of Oral Diseases
2017-2024
Central South University
2021-2024
Shaoxing University
2011-2024
Second Xiangya Hospital of Central South University
2021-2024
Gunma University
2024
University of Pittsburgh Medical Center
2024
University of Miami
2024
Sanofi (United States)
2024
Adipose tissue is an active endocrine organ that can secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition soluble proteins in adipose tissue, microRNAs (miRNAs) enriched extracellular vesicles (EVs), such as exosomes or microvesicles, could modulate intercellular communications. this study, we demonstrated exosome-like derived from (Exo-AT) were internalized by tissue-derived stem cells (ADSCs), and these, turn, induced adipogenesis. High-throughput...
Bone defect caused by trauma, neoplasia, congenital defects, or periodontal disease is a major cause of disability and physical limitation. The transplantation bone marrow mesenchymal stem cells (BMSCs) promotes repair regeneration. However, it has been shown that most BMSCs die within short period after transplantation. During apoptosis, generate large number apoptotic cell–derived extracellular vesicles (ApoEVs). This study aims to understand the potential role ApoEVs in craniofacial...
Due to the declined function of bone marrow mesenchymal stem cells (BMSCs), repair defects in elderly is retarded. Elimination senescent emerges as a promising strategy for treating age-related diseases. However, whether local elimination BMSCs can promote regeneration remains elusive. To tackle above issue, we first screened out specific senolytics and confirmed their effect eliminating vitro. Treatment with quercetin, which determined best BMSCs, efficiently removed population. Moreover,...
Abstract Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition supply. The approach based on endogenous stem cells a potential strategy for pulp regeneration. However, cell sources, exogenous regenerative signals, neovascularization are major difficulties regeneration cells. Therefore, purpose our research to seek an effective cytokines delivery bioactive materials reestablish ideal microenvironment In in vitro study, we investigated effects Wnt3a,...
Abstract Objectives Poor cell survival severely limits the beneficial effect of adipose‐derived stem ( ADSC )‐based therapy for disease treatment and tissue regeneration, which might be caused by attenuated level hypoxia‐inducible factor‐1 HIF ‐1) in these cells after having been cultured 21% ambient oxygen vitro weeks. In this study, we explored role pre‐incubation dimethyloxalylglycine DMOG , ‐1 activator) survivability human s a simulated ischaemic microenvironment vivo. The underlying...
This study assesses the safety and disease control outcomes in metastatic renal cell carcinoma (mRCC) patients undergoing concurrent tyrosine kinase inhibitors (TKI), immune checkpoint (ICIs), high-dose stereotactic ablative body radiotherapy (SABR) . Between February 2020 to May 2023, 54 mRCC receiving vascular endothelial growth factor (VEGF) targeted therapy ICIs with (RT) were included. Genetic testing was performed on 25 pathology samples using Acornmed 70™ panel. Endpoints included...
Purpose: Extracellular vesicles (EVs) are membrane-encapsulated nanoparticles that function as carriers and play a role in intercellular communication. There large number of EVs the blood serve an indicator pathophysiological conditions. Studies on basics application hampered by limitations current protocols to isolate from blood. However, isolation methods difficult achieve balance between yield purity. Methods: Firstly, we use Sepharose-4B build self-made size exclusion chromatography...
Although typically cultured at an atmospheric oxygen concentration (20–21%), adipose-derived stem cells (ASCs) reside under considerable low tension (physioxia) in vivo. In the present study, we explored whether and how physioxia could be a more effective strategy for culturing ASCs transplantation. After isolation, human were (2% O2) hyperoxia (20% until assayed. WST-8, Transwell, tube formation, β-galactosidase staining, annexin V-FITC/PI assays used to evaluate cell proliferation,...
Abstract The early stage of obesity is an important in the development obesity. However, there are few studies which explored property or changes at especially involving Wnt5a. associated gene expression Wnt5a on cell regeneration and effect rat adipose‐derived stem (rASC) proliferation adipogenesis need additional study. Here, we investigated how regulates rASC regeneration, proliferation, adipogenesis. Our data revealed that measured by Lee index presented a state with impaired more...
Artificial intelligence technology has attained rapid development in recent years. The integration of artificial applications into pressure reduction mattresses, giving rise to intelligence-powered is expected provide personalised intelligent solutions, through automatic user's data-based adjustment the patient's local condition prevent injury. purpose this study was investigate effectiveness smart decompression prevention postoperative medium- and high-risk injury middle-aged elderly patients.
Adipose tissue engraftment has become a well-established therapy in plastic and reconstructive surgery used to restore age-related or injury-related soft loss. However, the unpredictable absorption rates limit its further application. Some clinicians have noted that more optimal aesthetic results are achieved when botulinum toxin A (BoNTA) is applied prior adipose grafting. In present study, we transplanted allogeneic treated with without BoNTA SD rats vivo. We subsequently evaluated...