A5100653404- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Renal and related cancers
- Mesenchymal stem cell research
- Animal Genetics and Reproduction
- Chemical Reactions and Isotopes
- Virus-based gene therapy research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Sperm and Testicular Function
- Connexins and lens biology
- Biofuel production and bioconversion
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Polysaccharides and Plant Cell Walls
- Selenium in Biological Systems
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Retinal Development and Disorders
Jilin University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Anhui University
2018-2021
Central South University
2019
Nankai University
2018
Sichuan University
2017
State Key Laboratory of Oral Diseases
2017
Institute of Zoology
2016
Chinese Academy of Sciences
2016
Secondary cell death via gap junctions (GJs) plays a role in the propagation of neuronal loss under number degenerative disorders. Here, we examined GJs retina, which has arguably most diverse expression CNS. Initially, induced apoptotic by injecting single retinal ganglion cells and glia with cytochrome C found that this resulted neighboring to they were coupled GJs. We next pharmacological blockade eradicated nearly all amacrine reduced ∼70% after induction either excitotoxic or ischemic...
Abstract Objectives Poor cell survival severely limits the beneficial effect of adipose‐derived stem ( ADSC )‐based therapy for disease treatment and tissue regeneration, which might be caused by attenuated level hypoxia‐inducible factor‐1 HIF ‐1) in these cells after having been cultured 21% ambient oxygen vitro weeks. In this study, we explored role pre‐incubation dimethyloxalylglycine DMOG , ‐1 activator) survivability human s a simulated ischaemic microenvironment vivo. The underlying...
5-Hydroxytryptamine (5-HT) is an inhibitory neurotransmitter widely distributed in mammalian tissues, exerting its effects through binding to various receptors. It plays a crucial role the proliferation of granulosa cells (GCs) and development follicles female animals, however, effect on porcine follicle not clear. The aim this study investigate expression 5-HT receptors parts pig ovary, as well follicular by using ELISA, quantitative real-time PCR (qPCR) EdU assays. Firstly, we examined...
The genome-wide variation of multiple epigenetic modifications in CpG islands (CGIs) and the interactions between them are great interest. Here, we optimized an entropy-based strategy to quantify explored their interaction across mouse embryonic stem cells, neural precursor cells brain. Our results showed that four (DNA methylation, H3K4me2, H3K4me3 H3K27me3) CGIs genome undergo combinatorial during neuron differentiation. DNA methylation was positively correlated with H3K27me3 negatively...
Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the of controlling hESC activity and showed that functionally important maintenance identity. expression highly enriched hESCs dramatically decreases upon differentiation. Forced promoted self‐renewal. Functional analysis mutant forms revealed both CP2‐ SAM‐like domains are indispensable to maintain undifferentiated state...
Micro/nano-topography (MNT) can promote osteogenic differentiation of stem cells, but the mechanism topographical signaling transduction remains unclear. We have confirmed MNT, as a stressor, triggers endoplasmic reticulum (ER) stress and activates unfolded protein response in rat bone marrow mesenchymal such topography-induced ER promotes differentiation. In order to reveal influence nanotube dimensions on stress, MNTs containing vertically oriented TiO2 nanotubes diameters ranging from 30...
Pluripotent stem cells (PSCs) can differentiate into three germ layers and diverse autologous cell lines. Since cattle are the most commonly used large domesticated animals, an important food source, bioreactors, great efforts have been made to establish bovine PSCs (bPSCs). bPSCs potential in breeding reproduction, modeling vitro differentiation, imitating cancer development, diseases. Currently, mainly include embryonic (bESCs), induced pluripotent (biPSCs), expanded (bEPSCs). Establishing...
Embryonic stem cells (ESCs) are progenitor that retain the ability to differentiate into various cell types and necessary for tissue repair. Improving culture conditions maintain pluripotency of ESCs in vitro is an urgent problem field regenerative medicine. Here, we reveal Spautin-1, a specific small-molecule inhibitor ubiquitin-specific protease (USP) family members USP10 USP13, promotes maintenance self-renewal mouse vitro. Functional studies only knockdown but not USP10, capable...
Abstract Purpose In the central nerve system type 2 vesicular monoamine transporters (VMAT2) regulate reuptake of monoamines into pre-synaptic vesicles, playing a critical role in assessing neuron integrity including Parkinson's disease (PD). This study examined biodistribution and dosimetry novel deuterated VMAT2 radioligand, D6-[ 18 F]FP-(+)-DTBZ, comparing it head-to-head with its non-deuterated counterpart, [ F]FP-(+)-DTBZ (AV-133). Methods Six (6) healthy volunteers received intravenous...
Spermatogonial stem cells (SSCs) possess the characteristics of self-renewal and differentiation, as well ability to generate functional sperm. Their unique stemness has broad applications in male infertility treatment species preservation. In rodents, research on SSCs been widely reported, but progress is slow large livestock such cattle pigs due long growth cycles, difficult proliferation vitro, significant differences. Previously, we showed that histone 3 (H3) lysine 9 (K9) trimethylation...
A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, evaluated as HDAC inhibitors. It was interesting find the corresponding derivative 1 with 5-position a potent inhibitor while others not. This is first time demonstrate position difference plays important role in inhibitory activities cinnamic hydroxamates.
Embryonic stem cells (ESCs) is a highly undifferentiated pluripotent cells, can differentiate into various cells. Stem cell therapy an opportunity of the human regenerative medicine, and also focus medical research. While source embryonic controversial in ethics, which indirectly promotes technology development somatic reprogramming induced (iPSCs). Although iPSCs produce healthy mature individuals, there are still some limitations, such as success rate very low problem tumorigenicity. ESCs...