Y. Chang

ORCID: 0000-0002-9754-0825
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Cardiovascular Effects of Exercise
  • Frailty in Older Adults
  • Heart Rate Variability and Autonomic Control
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Imaging and Diagnostics
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Ischemia and Reperfusion
  • Cardiac Fibrosis and Remodeling
  • Health Systems, Economic Evaluations, Quality of Life
  • HIV/AIDS Research and Interventions
  • Nutrition and Health in Aging
  • Cancer survivorship and care
  • Exercise and Physiological Responses
  • Clinical practice guidelines implementation
  • Medical Research and Treatments
  • Adipose Tissue and Metabolism
  • Diabetes Management and Education
  • Advanced Technologies in Various Fields
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Oral health in cancer treatment
  • Advanced Glycation End Products research
  • Surgical Simulation and Training
  • Cerebrovascular and genetic disorders
  • Patient Safety and Medication Errors

Xi'an Polytechnic University
2025

Chang Gung University
2024

Chang Gung Memorial Hospital
2024

Osaka Prefectural Medical Center
2023-2024

Ming Chi University of Technology
2024

Zunyi Medical University
2024

Tianjin Third Central Hospital
2024

Tianjin Medical University
2024

Nankai University
2024

Linyi University
2023

Abstract Brain-derived neurotrophic factor (BDNF) is a myokine. However, its role in skeletal muscle has not been well elucidated. In this study, we aimed to investigate expression profile following downhill running and explore functions. Male Sprague Dawley rats were assigned sedentary groups. Tail vein blood, total mRNA protein from soleus was obtained at different time points post-exercise (1d, 3d, 5d, 7d 14d). We found significant elevation of BDNF level 5d (p<0.05), increased 1d, 14d...

10.1055/s-0043-118343 article EN International Journal of Sports Medicine 2017-10-01

Background Differences in border zone contribute to different outcomes post-infarction, such as left ventricular aneurysm (LVA) and myocardial infarction (MI). LVA usually forms within 24 h of the onset MI may cause heart rupture; however, surgery is best performed 3 months after MI. Few studies have investigated model, differences zones between MI, mechanism zone. Methods The LVA, SHAM mouse models were used. Echocardiography, Masson’s trichrome staining, immunofluorescence staining...

10.3389/fimmu.2024.1368516 article EN cc-by Frontiers in Immunology 2024-03-27

Up to now, studies of exercise-induced cardiac arrhythmia have focused primarily on the working myocardium, with few examining conduction system where rhythmic and synchronized contraction heart is initiated. To explore whether involved in injury, we performed histological analysis sinoatrial node, atrioventricular node Purkinje fibers tested level structural protein troponin T Connexin 43 Sprague Dawley rats following repeated exhaustive exercise. We found increased collagen deposition,...

10.1055/s-0034-1384545 article EN International Journal of Sports Medicine 2014-09-25

Intense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and development of MF unclear. This study aims to demonstrate is associated with cardiac damage, inflammation essential MF.Sprague-Dawley rats were submitted daily 60-minutes treadmill sessions at vigorous or moderate intensity, 8-, 12-, 16-week durations; time-matched sedentary served as controls. Enzyme-linked immunosorbent assay (ELISA) was used measure...

10.4070/kcj.2018.0084 article EN Korean Circulation Journal 2018-01-01

Abstract Background Remote ischemic periconditioning (RIPC) has demonstrated cardioprotective effects and improved clinical outcomes as an adjunct to emergent percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). However, it remains be elucidated whether RIPC affects the cardiac sympathetic nerve activity AMI. Purpose The purpose of this study is investigate effect on (CSNA) culprit non-culprit lesion respectively Methods We randomly assigned 157...

10.1093/eurheartj/ehae666.1665 article EN European Heart Journal 2024-10-01

To investigate the effect of reducing Lysyl oxidase (LOX) overexpression on retinal ganglion cells (RGCs) apoptosis in an acute ocular hypertension (AOH) rat model.

10.1080/02713683.2024.2371140 article EN Current Eye Research 2024-07-09

Abstract Background The activation of cardiac sympathetic nervous system is associated with poor prognosis in patients acute myocardial infarction (AMI). However, it remains to be determined whether regional assessment nerve activity (CSNA) the culprit and non-culprit lesion MIBG SPECT imaging could have prognostic value AMI. Purpose purpose this study investigate impact CSNA Methods We prospectively enrolled 122 AMI who visited our emergency department underwent primary percutaneous...

10.1093/eurheartj/ehae666.1530 article EN European Heart Journal 2024-10-01

Abstract Background Catheter ablation of atrial fibrillation (AF) might influence the cardiac sympathetic nervous system (CSNS). We sought to investigate impact AF with 2nd generation cryoballoon catheter (CB) and contact force sensing radiofrequency (RF) on CSNS association this effect early recurrence in patients without heart failure (HF), using iodine-123-metaiodobenzylguanidine (MIBG) scintigraphy. Methods Results One hundred sixty-five paroxysmal who were scheduled for enrolled. All...

10.1093/eurheartj/ehae666.534 article EN European Heart Journal 2024-10-01

10.1016/j.jsams.2017.01.204 article EN Journal of science and medicine in sport 2017-01-01

Type 2 Diabetes Mellitus(T2DM) is a metabolic diseases which characterized by hyperglycemia resulting from insulin secretion defects or action disorders. The hippocampus as one of the most important brain regions, really easy to be impaired T2DM. Resveratrol and exercise training have been considered useful measures for treating However, definite mechanism still unknown. PURPOSE:To investigate possible SIRT1 on effect Akt/PKB signaling pathway in T2DM rats. METHODS: 75 Male mature SD rats...

10.1249/01.mss.0000486567.30687.fd article EN Medicine & Science in Sports & Exercise 2016-05-01

10.1016/j.jss.2013.11.913 article EN Journal of Surgical Research 2014-01-07

Purpose: To determine an automatic procedure for determining the number and delineation of tumor habitats from Dynamic Contrast Enhanced (DCE) MRI data. Methods: An DCE-MRI datasets was developed as a two-part process involving: (1) statistical testing principal components dataset to detect (2) use this in unsupervised pattern recognition (PR) technique recover temporal location detected habitats. The tested on simulated with one, two, three unique patterns, corresponding well-perfused,...

10.1118/1.4955788 article EN Medical Physics 2016-06-01

PURPOSE: To study the subunit and current density of Hyperpolarization-activated cyclic nucleotide-gated channels(HCN channels)of sinoatrial node(SAN) at different time phrases after exhaustive exercise explore whether cardiac conduction system is involved in exercise-induced injury. METHODS: 180 healthy adult male SD rats were equally assigned into 9 groups,including 1 control groups, 4 groups undergoing single swimming(O group), 2-week repeated swimming(R group). The samples drawn from...

10.1249/01.mss.0000476832.03154.93 article EN Medicine & Science in Sports & Exercise 2015-05-01

Previous studies have reported that aerobic training reduces body fat content. Zinc alpha2 glycoprotein (ZAG), a lipid mobilizing factor, is negatively correlated with mass. The function of ZAG associated reduced fatty acid synthase (FAS) expression and increased hormone-sensitive lipase (HSL) in liver obese mice. We hypothesized up-regulate the ZAG, leading to reduction fat. PURPOSE: To determine underlying association between ZAG. METHODS: High-fat-diet (HFD)-induced mice were divided into...

10.1249/01.mss.0000486082.28514.8e article EN Medicine & Science in Sports & Exercise 2016-05-01

Objective To understand the quality of literature randomized controlled trials(RCTs) on oral hydration for prevention acute kidney injury after percutaneous coronary intervention published(PCI) in journals China. Methods Literature RCTs PCI published China was searched CBM, CNKI, Wan Fang data, and VIP database. And then, they were screened according to inclusion exclusion criteria. Besides, evaluated based Cochrane collaboration′s tool assessing risk bias Jadad scale. Results A...

10.3760/cma.j.issn.1674-2907.2016.22.019 article EN 2016-08-06

Objective To explore the therapeutic effect of erythropoietin (EPO)combined oral iron in patients with chronic congestive heart failure( CHF)accompanied by anemia. Methods Ninety six CHF accompanied anemia, whom were consecutively hospitalized from January 2007 to December 2009, enrolled into this study. They randomly divided treatment group accepted routine anti-heart failure therapy combined EPO and iron, control solely therapy. After 6 months follow up, changes hemoglobin ( Hb ), cardiac...

10.3760/cma.j.issn.1008-6315.2011.01.011 article EN Zhongguo zonghe linchuang 2011-01-01

Abstract Background ADIMIRE-HF risk score is a novel that combines clinical characteristics and MIBG imaging variables to predict serious arrhythmic in patients with chronic heart failure (CHF) recent studies showed highest occurrence of severe events (SAE) was seen an intermediate decrease uptake rather than the lowest values. Six-minute walk distance (6MWD) has also been shown detect high CHF. However, there no information available on long-term prognostic value these indices for...

10.1093/eurheartj/ehad655.319 article EN European Heart Journal 2023-11-01
Coming Soon ...