A5052833357- Bladder and Urothelial Cancer Treatments
- Advanced Battery Materials and Technologies
- Urinary and Genital Oncology Studies
- Advancements in Battery Materials
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Renal and related cancers
- Supercapacitor Materials and Fabrication
- Cancer Genomics and Diagnostics
- Advanced battery technologies research
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- MXene and MAX Phase Materials
- Radiomics and Machine Learning in Medical Imaging
- Advanced Battery Technologies Research
- Inflammatory Biomarkers in Disease Prognosis
- Poisoning and overdose treatments
- Graphene research and applications
- Ferroptosis and cancer prognosis
- Infectious Disease Case Reports and Treatments
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- ZnO doping and properties
- Colorectal Cancer Treatments and Studies
Peking University First Hospital
2014-2025
Peking University
2014-2025
Beijing Chest Hospital
2018-2025
Zhengzhou University
2019-2024
Hebei University of Science and Technology
2023-2024
China Medical University Hospital
2013-2024
China Medical University
2013-2024
China Tobacco
2024
Sichuan University of Science and Engineering
2024
Sungkyunkwan University
2021-2023
To evaluate the prognostic significance of novel index combining preoperative hemoglobin and albumin levels lymphocyte platelet counts (HALP) in renal cell carcinoma (RCC) patients.We enrolled 1360 patients who underwent nephrectomy our institution from 2001 to 2010. The cutoff values for HALP, neutrophil-to-lymphocyte ratio platelet-to-lymphocyte were defined by using X-tile software. Survival was analyzed Kaplan-Meier method, with differences log-rank test. Multivariate Cox...
BackgroundCholesteryl ester (CE) accumulation in intracellular lipid droplets (LDs) is an essential signature of clear cell renal carcinoma (ccRCC), but its molecular mechanism and pathological significance remain elusive.MethodsEnabled by the label-free Raman spectromicroscopy, which integrated stimulated scattering microscopy with confocal spectroscopy on same platform, we quantitatively analyzed LD distribution composition at single level intact ccRCC tissue specimens situ without any...
665 Background: This single-arm phase II trial was conducted to evaluate the efficacy and safety of neoadjuvent disitamab vedotin (DV, a HER2-targetted monoclonal antibody conjugated with monomethyl auristatin E) plus perioperative toripalimab (an anti-PD-1 inhibitor) in MIBC patients (pts) HER2 expression. The preliminary results showed promising acceptable neoadjuvant treatment DV pts HER2-expressing (Sheng, et al. ASCO Annual meeting 2024). Methods: Key eligibility criteria included...
Pyrite (FeS2) has been regarded as one of the most promising electrode materials for sodium ion batteries owing to high theoretical capacity and low cost. However, short cycle life FeS2 in storage hampers its further development. Although some researchers focused on mechanism fading Na/FeS2 battery, such irreversible crystal transform, terrible volume change, so on, whether how shuttling effect exists half-cell or full-cell systems still remain far. In this work, with is investigated...
Abstract Layered transition metal (TM) oxides of the stoichiometry Na x MO 2 (M = TM) have shown great promise in sodium‐ion batteries (SIBs); however, they are extremely sensitive to moisture. To date, most reported titanium‐based layered anodes exhibit a P2‐type structure. In contrast, O3‐type compounds rarely investigated and their synthesis is challenging due higher percentage unstable Ti 3+ than P2 type. Here, pure phase highly crystalline 0.73 Li 0.36 O with high performance...
Abstract Background Different genomic characterization in urothelial carcinoma (UC) by site of origin may imply contrasting therapeutic opportunities and pathogenetic mechanisms. The aim this study was to investigate whether differences between upper tract UC (UTUC) the bladder (UCB) result from intrinsic biological diversity. Materials Methods We prospectively sequenced 118 tumors matched blood DNA Chinese patients with using next-generation sequencing techniques, including 45 UTUC 73 UCB....
4566 Background: Disitamab vedotin has shown promising data across a spectrum of HER2 expression in patients with locally advanced or metastatic urothelial carcinoma (la/mUC) who progressed on chemotherapy. This study was conducted to evaluate the safety and efficacy disitamab plus anti-PD-1 antibody carcinoma. Methods: is an open-label, multicenter, phase 1b/2 trial activity RC48-ADC combined toripalimab, humanized immunoglobin G 4 monoclonal against PD-1 mUC. Patients received at 1.5 2...
529 Background: Metastatic RCC is a deadly disease and TKI in combination with IO has become standard therapy for most patients. But some of the pts may present oligo-metastasis meta site related symptoms. SABR (Stereotactic Ablative Body Radiotherapy) been proved to be highly effective studies potential immune-enhancing ability. The purpose investigate efficacy safety mRCC. Methods: This an ambispective cohort study including receiving at same time. primary endpoint was PFS. Secondary...
Abstract Background Tyrosine kinase inhibitors (TKIs) and immune checkpoint (ICIs) were recognized to cause endocrine adverse reactions (EARs). However, combination therapy-associated EARs are still unclear. Methods This was a retrospective study based on FDA Adverse Event Reporting System. We identified 938,464 cases of all events related three types treatments. A total 22,275 divided into TKIs (n=9,181), ICIs (n=11,363) TKIs+ICIs group (n=1,731). Results The incidence the highest in...
We present the nanoengineering of Sb particles assisted by a conductive and stress-relieving network carbon quantum dots (CQDs) poly(3,4-ethylene dioxythiophene) poly(styrenesulfonate) (PEDOT:PSS), in proper design anode materials with high specific capacity excellent stability for potassium-ion batteries (KIBs). The nanosized are prepared CQDs as functional tuners morphology surface, which tune size to nanolevel provide fast ionic channels soft matrix relieve volume changes. As additional...
Potassium–sulfur batteries have potential for low-cost and high-energy density energy storage. However, it is a challenge to find suitable electrolytes affording liquid environment intermediate sulfur species convert at high voltages. In this study, series of ether/potassium salt systems were systematically studied investigate the electrochemical stability function in electrochemistry by using situ ultraviolet–visible Fourier-transform infrared spectroscopies. Interactions soluble...
We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Using methylation-sensitive PCR, we examined ten genes in 687 UTUC A methylated of three predict higher tumor stage (T3 T4), five grade (G3) one pN+ were certified study. Nine factors significantly associated with poor cancer-specific survival. Six considered as develop bladder recurrence after surgery. Methylation occurs commonly UTUCs, may...
Objective: Previous research has demonstrated that patients with a history of organophosphate poisoning tend to have higher risk neurological disorder. However, on the rate seizure development in after is lacking. This study examined whether individuals an increased seizures through several years follow-up. Patients and Methods: We conducted retrospective cohort 45,060 (9012 36,048 controls) selected from Taiwan National Health Insurance Research Database. The were observed for maximum 12...
Potassium-sulfur batteries have attracted significant research attention owing to the naturally abundant resources of potassium and sulfur, promising applications in large-scale energy storage systems. However, sluggish reaction kinetics K+ , low activity sulfur species, shuttling effect polysulfides, large volume change impede development these batteries. Moreover, conventional electrode fabrication method with binders current collectors renders it difficult improve areal loading density....
4568 Background: Disitamab vedotin (DV) is a novel humanized anti-HER2 antibody-drug conjugate. DV plus toripalimab (a recombinant anti-PD-1 monoclonal antibody) showed promising antitumor activity in metastatic urothelial carcinoma (ASCO 2023). This study aimed to evaluate the safety and efficacy of as neoadjuvant therapy MIBC patients with HER2 expression. Methods: prospective multicenter phase 2 trial which planned enroll 40 pts. Primary endpoint pathological CR (pCR) rate; secondary...