A5101515207- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Trophoblastic Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Prenatal Screening and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Hippo pathway signaling and YAP/TAZ
- Neuropeptides and Animal Physiology
- Kruppel-like factors research
- Reproductive Physiology in Livestock
- Disaster Response and Management
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Herpesvirus Infections and Treatments
- Pregnancy and Medication Impact
- Wnt/β-catenin signaling in development and cancer
- Gestational Diabetes Research and Management
- Pregnancy-related medical research
Sichuan University
2013-2025
West China Second University Hospital of Sichuan University
2011-2025
Capital Medical University
2023-2025
Beijing Tongren Hospital
2023-2025
University of Science and Technology of China
2024
Bengbu Medical College
2024
Xiangya Hospital Central South University
2019-2024
Central South University
2019-2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Compared with long bone that arises from the mesoderm, major portion of maxillofacial bones and front skull are derived cranial neural crest cells undergo intramembranous ossification. Human skeletal stem have been identified in embryonic fetal bones. Here, we describe a single-cell atlas human mandible identify population cranio-maxillofacial (CMSSCs). These CMSSCs marked by interferon-induced transmembrane protein 5 (IFITM5) specifically located around periosteum jawbone frontal bone....
The imbalance in cell proliferation and apoptosis is considered an important role the pathogenesis of endometriosis, but exact mechanisms remains unclear. A newly established signaling pathway–Hippo/Yes-associated protein (YAP) pathway plays a critical processes. However, studies focusing on Hippo/YAP endometriosis are lacking.The objective was to explore function endometriosis.The expression YAP first investigated endometrium women with or without endometriosis. identified by transfection...
Do microRNAs (miRNAs) contribute to aberrant progesterone receptor (PGR) expression in the eutopic endometrium of women with endometriosis? miR-196a upregulates MEK/ERK signalling, mediating a downregulation PGR minimal or mild endometriosis. Implantation failure is strongly suggested as an underlying cause for observed infertility Progesterone resistance, which mainly caused by aberrantly expressed endometrium, considered key factor decreased endometrial receptivity; thus far, epigenetics,...
Abstract Background Window of implantation (WOI) displacement is one the endometrial origins embryo failure, especially repeated failure (RIF). An accurate prediction tool for receptivity (ER) extraordinarily needed to precisely guide successful implantation. We aimed establish an RNA-Seq-based test (rsERT) using transcriptomic biomarkers and evaluate benefit personalized transfer (pET) guided by this in patients with RIF. Methods This was a two-phase strategy comprising establishment...
Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis intrauterine adhesion (IUA). The stem cell theory diseases has been given hotspot, that human cells have isolated from the endometrium. Three transcription factors key roles maintaining pluripotency and self-renewal are sex-determining region Y-box2 (SOX2), Nanog homebox (NANOG), octamer-binding protein (OCT4), which may be responsible for damage or repair process uterine We aim...
To investigate the changes in cerebral hemispheric functional connections patients with acute acquired concomitant esotropia (AACE) and their relationship clinical manifestations, utilizing voxel-mirrored homotopic connectivity (VMHC). A prospective, observational study was conducted involving 32 AACE 31 age-, sex-, education-matched healthy controls (HC). The resting-state magnetic resonance imaging (rs-fMRI) signals, binocular vision function, psychometric scale scores were collected...
The precise etiology of endometriosis is not fully understood; the involvement stem cells theory a new hypothesis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play role in endometriosis. We aimed to analyze transcription factors sex-determining region Y-box 2 (SOX2), Nanog homeobox (NANOG), octamer-binding protein 4 (OCT4) endometrium reproductive-age women with without ovarian recruited 26 laparoscopy-diagnosed (endometriosis group) 16 disease-free...
To compare the therapeutic efficacy of clomiphene citrate (CC) and letrozole (LE) on ovulation, pregnancy, live birth in women with polycystic ovary syndrome (PCOS); to ensure if LE can replace CC as first-line therapy for ovulation induction these women. This is a prospectively, randomized, controlled trial tertiary hospital. Two-hundred sixty-eight anovulatory PCOS patients were treated by or plus metformin three continuous cycles conception; their rates, pregnancy rates calculated...
Abstract Background There is much value in identifying non-invasive ways of measuring endometrial receptivity, as it has the potential to improve outcomes following vitro fertilization (IVF). It been suggested that echogenicity on day hCG administration was a good marker receptivity. In daily practice, we notice patients with non-homogeneous hyperechoic endometrium embryo transfer usually have lower pregnancy rates. We therefore extended research onward transformation echo pattern after...
IL-6 has a dual role in bone remodelling. The ERK1/2 pathway partially upregulated secretion osteocyte-like MLO-Y4 cells exposed to CCF. We have now investigated the possible of phosphatidylinositol 3-kinase (PI3K)/Akt signalling CCF-induced expression. were treated with CCF 2,000 µstrain, 2 Hz, or 10, 30 min, 1, 3 and 6 h. expression, Akt PI3K/Akt phosphorylation determined by RT-PCR, ELISA Western blotting. Inhibition LY294002 PD98059 significantly attenuated upregulation, expression was...
The aims of the present study were to evaluate effectiveness transvaginal sonography (TVS) in detection endometrial polyps (EPs), and assess pregnancy outcome infertile women following hysteroscopic polypectomy. A total 145 diagnosed with primary or secondary infertility intrauterine disorders by TVS hysterosalpingography (HSG) included current study. All subjects divided into three groups based on findings, including EP, adhesion normal groups. EPs removed for biopsy adhesions treated....
Displaced window of implantation (WOI) is one the endometrial origins that accounts for failure, especially patients with recurrent failure (RIF), yet no standard diagnostic tool has been recognized. The study consists two parts, aiming to compare concordance and efficacy tools, newly developed RNA-seq based receptivity test (rsERT) conventional pinopode, in diagnosing WOI guiding personalized embryo transfer (pET). With same group RIF patients, rsERT diagnosed 32 (65.31%) normal WOIs, most...
Approximately half of the unexplained recurrent spontaneous abortions remain (URSAs). We aimed to provide novel insights into biological characteristics and related pathways differentially expressed genes (DE-genes), DE-methylated genes, DE-miRNAs in URSA, construct a molecular miRNAs-mRNAs network. Four data sets (GSE22490, GSE121950, GSE73025, GSE43256) were gained from GEO sets. identified DE-genes, using LIMMA package R software. Function enrichment analyses conducted DAVID. A...
Based on microRNA (miR) microarray analysis, we previously found that miR22-5p expression is decreased in the mid-luteal endometrium of women with minimal/mild endometriosis. Bioinformatics analysis predicted targets ten-eleven translocation (TET2) 3'-untranslated region. This study aimed to determine regulation and roles pathogenesis endometriosis-associated infertility. MiR22-5p TET2 from or without endometriosis was analyzed. After transfection mimics inhibitor, analyzed by quantitative...
Embryo implantation in a receptive endometrium is crucial for successful pregnancy. Endometrial receptivity (ER) prediction tools based on endometrial transcriptome biomarkers by biopsy have been used to guide embryo vitro fertilization (IVF) patients. However, no reliable noninvasive ER method has established, and one greatly needed. We aimed identify from uterine fluid transcriptomic sequencing data establishing tool evaluate its clinical application potential patients undergoing IVF.The...