A5004087890- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Head and Neck Anomalies
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Insect Resistance and Genetics
- Sarcoma Diagnosis and Treatment
- Insect and Pesticide Research
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- RNA and protein synthesis mechanisms
- Pancreatitis Pathology and Treatment
Naha City Hospital
2019-2024
Tokyo Denki University
2024
Tsuchiura Kyodo General Hospital
2020-2023
Aizawa Hospital
2011-2023
Isesaki Municipal Hospital
2023
Sanofi (United States)
2023
Isesaki Fukushima Hospital
2023
Novartis (United States)
2013-2016
Tokyo University of Agriculture
2016
Shinshu University
2000-2014
We demonstrate here that human melanocytes could be regulated by endothelin (ET) derivatives, potent vasoconstrictive peptides synthesized endothelial cells, to stimulate their proliferation and melanization via a receptor-mediated signal transduction pathway. Receptor-binding assay using [125I]ET indicated unlabeled ET-1 or ET-2 competitively inhibited each binding of labeled ETs with concentration for half-maximal inhibition (IC50) 0.7 0.9 nM, respectively. The dissociation constant (Kd)...
Human apolipoprotein B-100 (apoB-100), the ligand on low density lipoproteins that interacts with lipoprotein receptor and initiates receptor-mediated endocytosis catabolism, has been cloned, complete nucleic acid derived amino sequences have determined. ApoB-100 cDNAs were isolated from normal human liver cDNA libraries utilizing immunoscreening as well filter hybridization radiolabeled apoB-100 oligodeoxynucleotides. The mRNA is 14.1 kilobases long encoding a mature protein of 4536 acids...
Chronic moderate exercise has been reported to reduce pro-inflammatory cytokines. To analyze the molecular mechanisms by which training exerts these effects, epigenetic influences of age and on ASC gene, is responsible for IL-1β IL-18 secretion, were investigated gene methylation. Further, relationship between carcinogenesis exercise, methylation p15 tumor suppressive was also analyzed. High-intensity interval walking consisting 3 min low-intensity at 40% peak aerobic capacity followed a...
To elucidate the mechanisms that are involved in decrease of ceramide levels atopic dry skin and aged skin, we examined both activities beta-glucocerebrosidase, which is a major enzyme production, ceramidase, an essential degradation, stratum corneum skin. The specimens forearm were obtained by tape-stripping from 61 healthy volunteers 23 patients with uninvolved beta-glucocerebrosidase activity extracts was estimated using fluorescent 4-methylumbelliferyl-beta-D-glucopyranoside as...
Measurements of antithyroglobulin and antimicrosomal (antiperoxidase) antibodies have been performed widely for the clinical diagnosis autoimmune thyroid diseases. The present study was designed to compare these antibody titers with histological findings in patients diffuse goiter who were suspected having Hashimoto's thyroiditis. One hundred ten euthyroid or hypothyroid (10 males 100 females; age 48 ± 15 (SD) years old) studied measurement antiperoxidase by a hemagglutination technique...
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that defined by ETV6-NTRK3 gene fusion. There have been few case reports on the cytopathologic features of MASC to date. We examined clinicopathological and cytological seven cases RT-PCR analysis fusion gene. The occurred in three men four women aged between 39 68 years, with mean 51.6 years. In five these cases, tumor involved parotid gland. Histologically, all displayed predominantly microcystic...
Ciliated muconodular papillary tumor (CMPT) is a rare that arises in the peripheral lung fields and associated with proliferation of ciliate d goblet cells increased mucin production. We report case CMPT involving rearrangement anaplastic lymphoma kinase (ALK) gene. The patient was an 84‐year‐old Japanese female who had exhibited small nodular shadow on chest computed tomography during regular checkup 10 years ago. She underwent partial resection segment S10 right lung. cut surface surgical...
Ribosomal proteins are a major component of ribosomes and play critical roles in protein biosynthesis. Recently it has been shown that the ribosomal also function during various cellular processes independent biosynthesis therefore called extraribosomal functions. In this study we have, for first time, determined expression profile 12 (Sa, S8, S11, S12, S18, S24, L7, L13a, L18, L28, L32, L35a) normal epithelia human colorectal mucosa using immunohistochemistry (IHC) then compared their...
BACKGROUND Carcinosarcoma (malignant mixed mullerian tumor) of the female genital tract is a highly malignant neoplasm. The tumor stage and histologic grade carcinomatous component are among important prognostic indicators cited in literature for this tumor. METHODS Twenty-five patients with uterine carcinosarcoma at 4 hospitals Kyoto Nara areas Japan were studied retrospectively. clinicopathologic immunohistochemical data including p53, bcl-2, Ki-67, proliferating cell nuclear antigen...
// Mu Yang 1, * , Fangfang Liu 2, Kayoko Higuchi 3 Jinko Sawashita 4 Xiaoying Fu 5 Li Zhang 6 Lanjing 7, 8, 9, 10 2 Zhongsheng Tong Keiichi 1 Department of Aging Biology, Institute Pathogenesis and Disease Prevention, Shinshu University Graduate School Medicine, Matsumoto, Japan Breast Pathology Research Laboratory, Key Laboratory Cancer Prevention Therapy (Ministry Education), National Clinical Center for Cancer, Tianjin Medical Hospital, Tianjin, China Pathology, Aizawa Biological Sciences...
A total of 120 Bacillus thuringiensis strains was isolated from phylloplanes 35 species arboreous and herbaceous plants in an area northern Kyushu, Japan. The isolates belonged to at least 17 serotypes the group H serotype 3 predominant. Twenty were untypable by existing reference antisera 47 untestable due autoagglutination or poor motility. Of isolates, 25 produced bipyramidal parasporal inclusions others, spherical irregular-shaped. Insecticidal activity against mosquitoes (Culex pipiens...
Pseudo-acylceramides with different acyl properties were investigated for their capacity to restore diminished barrier function in essential fatty acid-deficient rats. Daily topical applications of synthetic pseudo-acylceramides containing ester-linked linoleic acid caused a dose-dependent, significant reduction transepidermal water loss (TEWL). Both other oleic or saturated alkyl chains and ordinary ceramides exhibited poor effect on recovery TEWL. Furthermore, pseudoceramide ether-linked...
Abstract Four specific monoclonal antibodies (MAbs) have been used to study distributions of fucosylated type‐2 chain polylactosamine antigens, Le x , poly y and sialylated ‐i in human lung cancer tissues the serum patients with cancers. Radioimmunoassay frequently showed abnormally high antigen levels sera 66 tested. When histological typing was performed, above 4 antigens were most observed adenocarcinoma lung; i.e. after combining results from 75% adenocardnoma positive (50% case...
The DNA, RNA, and protein of apo C-II have been analyzed in a patient with deficiency (apo C-IIHamburg). Markedly reduced levels plasma intrahepatic apolipoprotein were demonstrated by immunoblotting immunohistochemical analysis. Northern, slot blot, situ hybridization studies revealed low normal-sized mRNA. No major rearrangement the gene was detected Southern blotting. Sequence analysis genomic clones G-to-C substitution within donor splice site intron II. This base resulted formation new...
The human polyomavirus JC (JCV) replicates in the nuclei of infected cells. Here we report that JCV virions are efficiently assembled at nuclear domain 10 (ND10), which is also known as promyelocytic leukemia (PML) bodies. major capsid protein VP1, minor proteins VP2 and VP3, a regulatory called agnoprotein were coexpressed from polycistronic expression vector COS-7 We found VP1 accumulated to distinct subnuclear domains presence VP2/VP3 agnoprotein, while expressed alone was distributed...
apoB DNA, RNA, and protein from two patients with homozygous hypobetalipoproteinemia (HBL) were evaluated compared normal individuals. Southern blot analysis 10 different cDNA probes revealed a gene without major insertions, deletions, or rearrangements. Northern slot analyses of total liver mRNA HBL documented size that was present in greatly reduced quantities. ApoB detected within hepatocytes utilizing immunohistochemical techniques; however, it markedly quantity when control samples. No...
Gastric gland mucin secreted from the lower portion of gastric mucosa contains unique O-linked oligosaccharides having terminal α1,4-linked N-acetylglucosamine (αGlcNAc) residues largely attached to a MUC6 scaffold. Previously, we generated A4gnt-deficient mice, which totally lack αGlcNAc, and showed that αGlcNAc functions as tumor suppressor for cancer. Here, determine clinicopathological significance in carcinomas, examined immunohistochemical expression phenotypic markers including...
Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a risk‐stratification reporting system that was introduced in 2018. objective of this multi‐institutional study to evaluate the utility MSRSGC Japan. Methods In total, 1608 fine‐needle aspiration samples with matching histologic diagnoses were retrieved from 12 large institutions diagnostic categories assigned prospectively or retrospectively, and results compared diagnoses. Results cases classified as...
The acute activation of adrenal glucocorticoid synthesis by ACTH has long been believed to be mediated cAMP as the major second messenger, although increases in cellular concentration have not observed at low concentrations ACTH. We found that steroidogenesis bovine fasciculata-reticularis cells was activated addition arachidonic acid or its 15-lipoxygenase metabolite, 15-hydroperoxyeicosatetraenoic acid. pathway significantly 1 pM ACTH, which no increase observed. ACTH-induced stimulation...
Autoimmune pancreatitis (AIP) is a representative IgG4-related and inflammatory disease of unknown etiology. To clarify mechanisms carcinogenesis resulting from AIP, we focused on methylation abnormalities KRAS mutations in AIP.Six tumor suppressor genes (NPTX2, Cyclin D2, FOXE1, TFPI2, ppENK, p16) that exhibited hypermethylation pancreatic carcinoma were selected for quantitative SYBR green methylation-specific polymerase chain reaction 10 AIP specimens, adenocarcinoma cases without history...