Hiroshi Nosé

ORCID: 0000-0003-0994-1619
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About
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Research Areas
  • Thermoregulation and physiological responses
  • Cardiovascular and exercise physiology
  • Heart Rate Variability and Autonomic Control
  • Exercise and Physiological Responses
  • Infrared Thermography in Medicine
  • Physical Activity and Health
  • Sports Performance and Training
  • Magnetic properties of thin films
  • Adipose Tissue and Metabolism
  • Muscle metabolism and nutrition
  • High Altitude and Hypoxia
  • Magnetic Properties and Applications
  • Thermal Regulation in Medicine
  • Neuroendocrine regulation and behavior
  • Neuroscience of respiration and sleep
  • Balance, Gait, and Falls Prevention
  • Theoretical and Computational Physics
  • Circadian rhythm and melatonin
  • Stress Responses and Cortisol
  • Magnetic Properties of Alloys
  • Hemodynamic Monitoring and Therapy
  • Electrolyte and hormonal disorders
  • Metallic Glasses and Amorphous Alloys
  • Renal function and acid-base balance
  • Dietary Effects on Health

Shinshu University
2014-2024

Tokyo Women's College of Physical Education
2022

Osaka Sangyo University
2022

Matsumoto University
2018

University of Tsukuba
2017

Shinshu University Hospital
2017

Physiological Society
2016

University of Manchester
2016

King's College London
2016

Rotherham General Hospital
2016

Chronic moderate exercise has been reported to reduce pro-inflammatory cytokines. To analyze the molecular mechanisms by which training exerts these effects, epigenetic influences of age and on ASC gene, is responsible for IL-1β IL-18 secretion, were investigated gene methylation. Further, relationship between carcinogenesis exercise, methylation p15 tumor suppressive was also analyzed. High-intensity interval walking consisting 3 min low-intensity at 40% peak aerobic capacity followed a...

10.1055/s-0029-1246140 article EN International Journal of Sports Medicine 2010-03-03

To examine the role of cardiopulmonary (CP) mechanoreceptors in regulation arterial blood pressure during dynamic exercise humans, we measured mean (MAP), cardiac output (Q), and forearm flow (FBF) mild cycle ergometer (77 W) 14 volunteers supine position with without lower-body negative (LBNP). During exercise, MAP averaged 103 +/- 2 mmHg was not altered by LBNP (-10, -20, or -40 mmHg). Steady-state Q reduced from 10.2 0.5 to 9.2 l/min (P less than 0.05) application -10 LBNP, whereas heart...

10.1152/jappl.1988.65.4.1827 article EN Journal of Applied Physiology 1988-10-01

The excitation of spin wave resonance is investigated for various Ni films. observation possible only in the case film prepared on unheated glass substrate. It sensitive to inner crystalline structure film. exchange coupling constant A estimated be 0.75×10 -6 erg/cm and integral J 9.4×10 -14 erg. Similarly Pd- Cu-Ni alloy films are prepared. Their concentrations determined. They confirmed have nearly perfect by means electron diffraction. With increasing concentration Pd Cu, value decreases...

10.1143/jpsj.16.2475 article EN Journal of the Physical Society of Japan 1961-12-01

We assessed the effects of aerobic and/or resistance training on thermoregulatory responses in older men and analyzed results relation to changes peak oxygen consumption rate (V˙o 2 ) blood volume (BV). Twenty-three [age, 64 ± 1 (SE) yr; V˙o , 32.7 1.1 ml · kg −1 min ] were divided into three regimens for 18 wk: control (C; n = 7), (AT; 8), (RT; 8). Subjects C allowed perform walking ∼10,000 steps/day, 6–7 days/wk. AT exercised a cycle ergometer at 50–80%V˙o 60 min/day, 3 days/wk, addition...

10.1152/japplphysiol.00222.2002 article EN Journal of Applied Physiology 2002-11-01

To reveal the role of clock genes in generating circadian rhythm baroreflexes, we continuously measured mean arterial pressure and baroreflex sensitivity free-moving normal wild-type mice, Cry-deficient mice which lack a rhythm, constant darkness for 24 h. In was higher at night than during day, accompanied by significantly enhanced -13.6 +/- 0.8 compared with -9.7 0.7 beats min(-1) mmHg(-1) day (P < 0.001). On other hand, diurnal changes disappeared remarkably 0.001): -21.9 1.6 -23.1 2.1...

10.1113/jphysiol.2005.086728 article EN The Journal of Physiology 2005-04-29

Dehydration amounting to about 10% of body weight was induced in adult male rats by exposure a hot, dry environment (D.B.T., 36°C; R.H., 20%) over 6 8hr. The volumes total water (TW), extracellular fluid (ECF), and plasma (PV) were determined both on individual tissues the whole using constant as well 51Cr-EDTA 125I-RIHSA dilution methods. Total (TBW), intracellular (ICF), interstitial (ISF) calculated from these data.The loss caused decrease TBW 17% control value; 41% this ICF, 47% ISF, 12%...

10.2170/jjphysiol.33.1019 article EN The Japanese Journal of Physiology 1983-01-01

Hypothesis Whether increasing peak aerobic capacity for walking (V̇ 2peak ) by interval training (IWT) is closely linked with decreasing the indices of lifestyle-related diseases (LSDs) in middle-aged and older people were examined. Methods For 4 months from April to September 2005 or 2006, 246 males 580 females (∼65 years) performed IWT consisting ≥5 sets fast at ≥70% V̇ 3 min followed slow ≤40% ≥4 days/week. Before after IWT, we measured , body mass index (BMI), %body fat, arterial blood...

10.1136/bjsm.2009.064816 article EN British Journal of Sports Medicine 2009-10-21

The stimulus-response characteristics of cardiopulmonary baroreflex control forearm vascular resistance (FVR) were studied in five unfit [UF, maximal O2 consumption (VO2 max) = 38.5 ml X min-1 kg-1] and six fit (F, VO2 max 57.0 kg-1) subjects. We assessed the relationship between reflex stimulus, i.e., changes central venous pressure (CVP) response, FVR, during selective unloading mechanoreceptors with lower body negative (0 to -20 mmHg). linear FVR CVP, gain this baroreflex, was...

10.1152/jappl.1987.63.1.105 article EN Journal of Applied Physiology 1987-07-01

To examine whether the biased estimation of oxygen consumption rate (VO2, mL x kg(-1) min(-1)) by accelerometry during incline walking can be improved addition altitude changes as measured barometry.We VO2 respiratory gas analysis and vector magnitude (VM, G) from triaxial accelerations in 42 healthy people (mean +/- SD age = 63 7 yr) graded on a treadmill while was varied -15% to +15%. They walked at subjectively slow, moderate, fast speeds level uphill inclines and, these, their fastest...

10.1249/mss.0b013e3181a9c452 article EN Medicine & Science in Sports & Exercise 2009-11-14

We examined whether protein-carbohydrate (CHO) supplementation immediately after exercise each day during aerobic training facilitated plasma volume (PV) expansion and thermoregulatory cardiovascular adaptations in older men. Fourteen moderately active men [68 +/- 5 (SD) yr] were divided into two groups so as to have no significant differences anthropometric measures, PV, peak oxygen consumption rate (Vo(2peak)). Each group was provided with a mixture of protein CHO (3.2 kcal, 0.18 g...

10.1152/japplphysiol.91265.2008 article EN Journal of Applied Physiology 2009-07-17

Magnetic properties of TiFe x Co 1- have been measured at temperatures between 4.2 and 300 K. For the compositions 0.4≦ ≦0.8 they are interpreted in terms a weak itinerant electron ferromagnet model. The slope M 2 versus H / curves rapidly increases with decreasing iron concentration, which is good agreement result expected from electronic specific heat coefficient.

10.1143/jpsj.35.409 article EN Journal of the Physical Society of Japan 1973-08-01

Niobium thin films are prepared by evaporation in ultra-high vacuum system with an electron beam and their superconducting properties examined as a function of film thickness temperature. An inflection point appearing the temperature dependence parallel critical field H c // is explained coherence length ξ( t ). The perpendicular ⊥ varies 1- independently thickness. ξ(0) at 0°K some estimated three methods. Anomalous results that minimum occurs on angular ratio / becomes lower than 1.69...

10.1143/jpsj.26.347 article EN Journal of the Physical Society of Japan 1969-02-01

Plasma volume (PV) expansion by endurance training and/or heat acclimatization is known to increase aerobic and thermoregulatory capacities in humans. Also, higher erythrocyte (EV) fractions blood are improve these capacities. We tested the hypothesis that a hypobaric hypoxic warm environment would peak power (V˙o 2 ) forearm skin vascular conductance (FVC) response increased esophageal temperature (T es more than either alone, increasing both PV EV. Twenty men were divided into four...

10.1152/jappl.2001.91.4.1520 article EN Journal of Applied Physiology 2001-10-01

10.1016/0022-3697(78)90008-2 article EN Journal of Physics and Chemistry of Solids 1978-01-01

Plasma proteome analysis requires sufficient power to compare numerous samples and detect changes in protein modification, because the content of human varies significantly among individuals, many plasma proteins undergo bloodstream. A label-free proteomics platform developed our laboratory, termed "Two-Dimensional Image Converted Analysis Liquid chromatography mass spectrometry (2DICAL)," is capable these tasks. Here, we describe successful detection novel prolyl hydroxylation...

10.1074/jbc.m109.041749 article EN cc-by Journal of Biological Chemistry 2009-08-21

We examined whether protein and carbohydrate (CHO) supplementation during 5-day training enhanced plasma volume (PV) expansion thermoregulatory cardiovascular adaptations in young men. Eighteen men [age 23 ± 4 (SD) yr] were divided into two groups according to supplements: placebo (CNT: 0.93 kcal/kg, 0.00 g protein/kg, n = 9) CHO (Pro-CHO: 3.6 0.36 9). Subjects both performed a cycling exercise at 70% peak oxygen consumption rate (VO2peak), 30 min/day, for 5 consecutive days 30°C ambient...

10.1152/japplphysiol.00577.2010 article EN Journal of Applied Physiology 2010-08-06

This study examined whether increased plasma volume (PV) and albumin content (Alb(cont)) in for 23 h after exercise were attenuated older subjects compared with young adult subjects, if this attenuation abated by supplementation protein carbohydrate (CHO) immediately exercise. Eight moderately active (approximately 68 yr) 8 21 men performed two trials: control (CNT) Pro-CHO which consumed placebo (0.5 kcal, 0 g protein, 0.5 mg Na(+) 3.2 ml total fluid volume/kg body wt) or CHO mixture (3.2...

10.1152/japplphysiol.91264.2008 article EN Journal of Applied Physiology 2009-07-10

We examined whether enhanced cardiovascular and thermoregulatory responses during exercise after short-term aerobic training in a warm environment were reversed when plasma volume (PV) expansion was by acute isotonic hypohydration. Seven young men performed at the 70% peak oxygen consumption rate (Vo(₂peak)) 30°C atmospheric temperature 50% relative humidity, 30 min/day for 5 days. Before training, we response test while measuring esophageal (T(es)), forearm skin vascular conductance, sweat...

10.1152/japplphysiol.01193.2010 article EN Journal of Applied Physiology 2011-02-10

No long-term exercise training regimen with high adherence and effectiveness in middle-aged older people is broadly available the field. We assessed to, effects of, our program comprising an interval walking (IWT) information technology network system factors affecting adherence. Middle-aged men women [ n = 696, aged 65 ± 7(SD) yr] underwent IWT. The subjects were instructed to repeat five or more sets of fast slow for 3 min each at ≥70 40% peak aerobic capacity (V̇o 2peak ), respectively,...

10.1152/japplphysiol.00819.2014 article EN Journal of Applied Physiology 2014-12-24

Physical fitness has been reported to decrease the risk of lifestyle-related diseases. The present study evaluated genome-wide methylation under hypothesis that interval walking training (IWT) imparted beneficial effects on health, particularly by epigenetically ameliorating susceptibility inflammation. We screened DNA from peripheral blood samples via microarray for genes whose was affected IWT, paying special attention promoter regions, and identified over 40 hyper- or hypo-methylated...

10.1055/s-0035-1547221 article EN International Journal of Sports Medicine 2015-04-22

Patients with Alzheimer's disease (AD) often present apathy symptoms resembling the decreased motivation observed in depressed patients. Therefore, differentiating initial phase of AD from late life depression may be difficult some cases. Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that uses near-infrared light to measure changes hemoglobin concentration on cortical surface during activation tasks. The objective this study was investigate differences brain...

10.1186/1744-9081-10-8 article EN cc-by Behavioral and Brain Functions 2014-01-01
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