A5031006826- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Sleep and related disorders
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Treatment of Major Depression
- Diet and metabolism studies
- Child Development and Digital Technology
- Parkinson's Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Electroconvulsive Therapy Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Metabolomics and Mass Spectrometry Studies
- Obsessive-Compulsive Spectrum Disorders
- Pharmacological Effects and Toxicity Studies
- Eating Disorders and Behaviors
- Circadian rhythm and melatonin
Shinshu University
2015-2024
Shinshu University Hospital
2008-2023
Ōtani University
2016-2023
National Center of Neurology and Psychiatry
2013-2022
Social Welfare Organization Saiseikai Imperial Gift Foundation
2013
Ikeda Municipal Hospital
2010
Aim: An increasing number of neuroimaging studies have been conducted to uncover the pathophysiology attention‐deficit–hyperactivity disorder (ADHD). The findings are inconsistent, however, at least partially due methodological differences. In present study voxel‐based morphometry (VBM) was used evaluate brain morphology in ADHD subjects after taking into account confounding effect oppositional defiant (ODD) and conduct (CD) comorbidity. Methods: Eighteen children with 17 age‐ gender‐matched...
The DSM-IV recognizes some subtypes of major depressive disorder (MDD). It is known that the effectiveness antidepressants differs among MDD subtypes, and thus differentiation important. However, little as to structural brain changes in with atypical features (aMDD) comparison melancholic (mMDD), which prompted us examine possible differences white matter integrity assessed diffusion tensor imaging (DTI) between these two subtypes.Subjects were 21 patients mMDD, 24 aMDD, 37 age- sex-matched...
Major depressive disorder (MDD) presumably includes heterogeneous subgroups with differing pathologies. To obtain a marker reflecting such subgroup, we analyzed the cerebrospinal fluid (CSF) levels of fibrinogen, which has been reported to be elevated in plasma patients MDD. Three fibrinogen-related proteins were measured using aptamer-based analyses and CSF samples 30 MDD controls. The numbers an excessively high level (>99 percentile controls) was significantly increased (17 23%)....
Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia well mood disorders. Some evidence suggests that this polymorphism plays role in cognitive function both patients and healthy individuals; however, precise nature remains unclear. Here we investigated possible with wide range neurocognitive functions subjects. Schizophrenia exhibited significantly poorer performance on all domains compared to controls. In patients,...
Amino acids play key roles in the function of central nervous system, and their alterations are implicated psychiatric disorders. In search for a biomarker major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino related molecules cerebrospinal fluid (CSF) 52 patients with MDD (42 depressed 10 remitted; DSM-IV) 54 matched controls. Significant differences were found four acid concentrations between After Bonferroni correction, only ethanolamine (EA)...
Cerebrospinal fluid (CSF) is virtually the only one accessible source of proteins derived from central nervous system (CNS) living humans and possibly reflects pathophysiology a variety neuropsychiatric diseases. However, little known regarding genetic basis variation in protein levels human CSF. We examined CSF 1,126 133 subjects performed genome-wide association analysis 514,227 single nucleotide polymorphisms (SNPs) to detect quantitative trait loci (pQTLs). To be conservative, Spearman's...
Abstract To examine the role of neuroplasticity in pathology psychiatric disorders, we measured cerebrospinal fluid (CSF) neuroplasticity-associated protein levels. Participants were 94 patients with schizophrenia, 68 bipolar disorder (BD), 104 major depressive (MDD), and 118 healthy controls, matched for age, sex, ethnicity (Japanese). A multiplex immunoassay (22-plex assay) was performed to measure CSF Among 22 proteins, 11 successfully assay. amyloid precursor (APP) glial cell-derived...
Abstract Several microarray-based studies have investigated gene expression profiles in major depressive disorder (MDD), yet with highly variable findings. We examined blood-based genome-wide signatures of MDD, focusing on molecular pathways and networks underlying differentially expressed genes (DEGs) behaviours hypothesis-driven, evidence-based candidate for depression. Agilent human whole-genome arrays were used to measure 14 medication-free outpatients MDD who at least moderately ill...
Aim: Accumulating evidence suggests that neural inflammation plays an important role in psychiatric disorders. We aimed to identify inflammatory cytokines involved the pathophysiology of such disorders by quantifying them cerebrospinal fluid (CSF) samples from a large sample patients with major and healthy controls. Methods: The subjects included 94 schizophrenia, 68 bipolar disorder, 104 depressive 118 controls, matched for age, sex, ethnicity (Japanese). Lumbar puncture was performed...
Article AbstractObjective: Many studies have investigated cerebrospinal fluid (CSF) monoamine metabolite levels in depressive disorders. However, their clinical significance is still unclear. We tried to determine whether CSF could be a state-dependent marker for major disorder (MDD) based on analyses stratified by variables relatively large sample.Methods: Subjects were 75 patients with MDD according DSM-IV criteria and 87 healthy controls, matched age, sex, ethnicity (Japanese). They...