A5063443996- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Grouting, Rheology, and Soil Mechanics
- Asthma and respiratory diseases
- Nuclear and radioactivity studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Graphite, nuclear technology, radiation studies
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Tunneling and Rock Mechanics
- Drilling and Well Engineering
- Geotechnical Engineering and Underground Structures
- Intracranial Aneurysms: Treatment and Complications
- IL-33, ST2, and ILC Pathways
- Soil and Unsaturated Flow
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Abdominal Surgery and Complications
- COVID-19 Clinical Research Studies
- Advanced ceramic materials synthesis
- Helicobacter pylori-related gastroenterology studies
- Nuclear Materials and Properties
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
The University of Tokyo
2016-2025
Musashino University
2015-2023
University of Tokyo Health Sciences
2020
Kyushu University
2020
Fukuoka Dental College
2019-2020
Nippon Dental University Hospital
2006-2019
University of Yamanashi
2018
National Center of Neurology and Psychiatry
2018
Shimizu (Japan)
1992-2017
University Hospital of Basel
2017
Although recent epidemiological studies on the pervasive development disorders (PDD) appear to be reporting higher rates of incidence than previously believed, great variation in reported figures suggests a need for review methodology involved. As such, survey PDD was conducted and compared with data from previous examine effects screening diagnostic incidence.The developmental surveyed all children (12 589) born between January 1994 December 1996 Toyota, Japan.Incidence 1.81% ratio boys...
Nanostructured β‐SiC, with crystallite size in the range of 5–20 nm agglomerates 50–150 nm, was formed by reactive high‐energy ball milling and consolidated to a relative density 98% sintering at 1700°C without use additives. X‐ray line broadening analysis gave 25 while transmission electron microscopy observations showed be 30–50 nm. Evidence demonstrating role disorder–order transformation densification process is provided changes diffraction peak patterns integral width temperature.
Abstract TLRs recognize microbial products. Their subcellular distribution is optimized for recognition. Little known, however, about mechanisms regulating the of TLRs. LPS recognized by receptor complex consisting TLR4 and MD-2. Although MD-2, a coreceptor TLR4, enhances cell surface expression an additional mechanism has been suggested. We show here that PRAT4A, novel protein associated with regulates TLR4. PRAT4A immature form but not MD-2 or TLR2. knockdown abolished responsiveness in...
Zymosan activates phagocytes through the innate immune system and causes inflammatory responses in animals. Because of complexity active substances included preparations, simplifying moiety actually responsible for recognition is needed. One way to remove possible from commercially available preparations wash then with pyrogen-free water obtain a ZWIS (Zymosan insoluble fraction), ethanol (EtIS), or chloroform/methanol (CMIS) preparation. The effects various washed on nuclear factor (NF)-κB...
Chronic obstructive pulmonary disease (COPD) and diffuse panbronchiolitis (DPB) are both characterized by chronic airflow limitation. Although the aetiology of these diseases is under investigation, it commonly hypothesized that neutrophils have a major role in pathogenesis. The variation genes related to chemotaxis may confer risk for development COPD DPB. In present report, authors investigated association between genetic codes 416th 420th amino acid Gc-globulin, reported be associated...
The impermeability of bentonite is dependent on montmorillonite microstructures and varies with chemical alteration caused by related changes. Kozeny-Carman equation viewed as a rational hydraulic model for because it incorporates microstructure parameters such specific surface area in addition to macrostructure the void ratio. In study reported here, technique measuring compacted under constant volume conditions using X-ray diffraction was developed, conductivity various materials evaluated...
Abstract Several clinical trials have shown that the humoral response produced by anti-spike antibodies elicited coronavirus disease 2019 (COVID-19) vaccines gradually declines. The kinetics, durability and influence of epidemiological factors on cellular immunity not been fully elucidated. We analyzed immune responses BNT162b2 mRNA in 321 health care workers using whole blood interferon-gamma (IFN-γ) release assays. IFN-γ, induced CD4 + CD8 T cells stimulated with severe acute respiratory...
The purpose of this study is to demonstrate the use a deep learning model in quantitatively evaluating clinical findings typically subject uncertain evaluations by physicians, using binary test results based on routine protocols. A chest X-ray most commonly used diagnostic tool for detection wide range diseases and generally performed as part regular medical checkups. However, when it comes that can be classified within normal but are not considered disease-related, thresholds physicians’...
Abstract Attention deficit–hyperactivity disorder (ADHD) has been noted for its high rate of comorbidity. The present study is the first report in Japan evaluating proportion comorbidity ADHD cases presenting clinical setting, aiming at clarifying picture Japan. subjects consisted 68 child and adolescent meeting criteria ( Diagnostic Statistical Manual Mental Disorders , 4th edn) under treatment a psychiatry clinic (IQ > 50, mental age ≥ 4 years old). evaluated as comorbid disorders were...
The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage induced in G(1) phase. Association of both Cdt2 PCNA with chromatin was observed after UV irradiation. Here we used a micropore irradiation assay to examine accumulation at cyclobutane pyrimidine dimer-containing DNA-damaged sites the process degradation HeLa cells. Cdt2, present nucleus throughout cycle, accumulated rapidly damaged...
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor with dismal prognosis. Recently, molecular subtypes of SCLC have been defined by the expression status ASCL1, NEUROD1, YAP1, and POU2F3 transcription regulators. ASCL1 essential for differentiation expressed in majority SCLC. Although previous studies investigated target genes cells, ASCL1-mediated regulation miRNAs its relationship to remain poorly explored. Here, we performed genome-wide profiling chromatin...
Abstract Background Type 2 innate lymphoid cells (ILC2s) are one of the sources IL‐5 and IL‐13 in allergic airway inflammation. Innate immune receptors such as Toll‐like (TLRs) expressed on epithelial could contribute to ILC2 activation through IL‐33 production, but a direct effect TLRs ILC2s remains be elucidated. Objectives We hypothesized that can directly activate lung participate pathogenesis asthma. Methods After intranasal administration wild‐type (WT), TLR2KO TLR4KO female mice, were...
Adverse reactions after vaccination with COVID-19 mRNA vaccines are common; however, the association between adverse and humoral responses is uncertain. To determine whether immune BNT162b2 vaccine administration were associated local systemic reactions, we conducted a prospective observational cohort study in single tertiary referral center. Healthcare workers who received first dose of recruited. SARS-CoV-2 anti-spike IgG antibody titers measured three weeks second information about was...
Abstract Acute exacerbation of chronic obstructive pulmonary disease (COPD) is often induced by infection and has a poor prognosis. Bacterial LPS activates innate immune receptor TLR4 followed activation transcriptional factor IFN regulatory factor-3 (IRF3) as well NF-κB, resulting in upregulation various inflammatory mediators. To clarify the role IRF3 pathogenesis LPS-triggered COPD exacerbation, porcine pancreatic elastase (PPE) was administered intranasally to wild-type (WT) or IRF3−/−...
We investigate a heating phenomenon in periodically driven integrable systems that can be mapped to free-fermion models. find the high-temperature state, which is typical scenario nonintegrable systems, also appear time-periodic systems; amount of energy absorption rises drastically near frequency threshold where Floquet-Magnus expansion diverges. As driving period increases, we observe effective temperatures generalized Gibbs ensemble for conserved quantities go infinity. By use scaling...
Abstract House dust mites ( HDM s) are a common source of allergens that trigger both allergen‐specific and innate immune responses in humans. Here, we examined the effect allergen concentration involvement Toll‐like receptor 4 TLR 4) process sensitization to house mite an extract‐induced asthma mouse model. Intranasal administration extract induced immunoglobulin E response eosinophilic inflammation dose‐dependent manner from 2.5 30 μg/dose. In 4‐knockout mice, infiltration eosinophils...
Abstract The annual incidence of neuroblastoma in Japan, a common malignancy young children which has very poor prognosis progressive cases, was previouly estimated to be 8.2 cases/million under 15 years age. Based on the Japanese National Census Population for 1982, number cases this tumor is predicted 220. (Sawada et al: Med Pediatr Oncol 12:101‐103, 1984). Before mass screening program started, one‐fourth all were detected before age one by clinical symptoms and other findings. Since...