A5062278424- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Gastroesophageal reflux and treatments
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Pathology Studies
- Acute Lymphoblastic Leukemia research
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Dermatology and Skin Diseases
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Photodynamic Therapy Research Studies
- Pharmaceutical studies and practices
- Cancer Genomics and Diagnostics
The University of Tokyo
2013-2025
University Health Network
2022-2024
Toronto General Hospital
2022-2024
University of Toronto
2024
Health Net
2023
University of Tokyo Hospital
2013-2021
Systems Biology Institute
2016-2018
Tokyo National Hospital
2018
National Cancer Center Hospital East
2016
Abstract Next‐generation sequencing ( NGS ) has been implemented in clinical oncology to analyze multiple genes and guide therapy. In patients with advanced lung cancer, small biopsies such as computed tomography‐guided needle biopsy CTNB ), endobronchial ultrasound‐guided transbronchial aspiration EBUS ‐ TBNA TBB are less invasive preferable resection make a pathological diagnosis. However, the quality of DNA / RNA from tumor samples is unknown. Between April 2017 March 2018, 107...
Certain proteases derived from house dust mites and plants are considered to trigger initiation of allergic airway inflammation by disrupting tight junctions between epithelial cells. It is known that inhalation such as mite-derived Der p1 and/or papaya-derived papain caused eosinophilia in naïve mice even Rag-deficient lack acquired immune cells T, B NKT In contrast, little regarding the possible involvement Aspergillus species (fungal-associated proteases; FAP), which ubiquitous...
IL-17C, which is a member of the IL-17 family cytokines, preferentially produced by epithelial cells in lung, skin and colon, suggesting that IL-17C may be involved not only host defense but also inflammatory diseases those tissues. In support that, was demonstrated to contribute development T cell-dependent imiquimod-induced psoriatic dermatitis cell-independent dextran sodium sulfate-induced acute colitis using mice deficient and/or IL-17RE, component receptor for IL-17C. However, roles...
Bronchial asthma is a chronic airway disease characterized by eosinophilic inflammation. Lung fibroblasts activated IL-13 serve as important sources of chemokines, such eotaxins, contributing to persistent Src-homology 2-containing protein (CISH), belonging the suppressor cytokine signaling (SOCS) family, acts negative regulator induction. The aim this study was elucidate role CISH in production eosinophil chemotactic chemokines human lung fibroblasts.Normal were stimulated IL-13, and global...
Patient-derived xenografts (PDXs) are increasingly utilized in preclinical drug efficacy studies due to their ability retain the molecular, histological, and response characteristics of patient tumors. This study aimed investigate factors influencing successful engraftment PDXs. Lung adenocarcinoma PDXs were established using freshly resected tumor tissues obtained through surgery. Radiological data pulmonary nodules from this PDX cohort analyzed, categorizing them into solid tumors with...
Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect TJ-14 on tolerability chemotherapy CPT-11 has not been fully investigated. We Japanese Diagnosis Procedure Combination inpatient database retrospectively identify patients who had received their first admission without TJ-14. Patients did receive (N =...
Adjuvant chemotherapy with vinorelbine plus cisplatin (VNR/CDDP) is a standard regimen for treatment of postoperative stage II-IIIA non-small cell lung cancer (NSCLC). However, oral fluorouracil offers feasible alternative adjuvant chemotherapeutic regimen. We compared the prognoses patients NSCLC treated either VNR/CDDP or fluorouracil. identified who underwent surgery followed by (n = 384) 268) between July 2010 and March 2015, using national Japanese inpatient outpatient Diagnosis...
Background Inhaled corticosteroids (ICSs) are used for advanced-stage chronic obstructive pulmonary disease (COPD). The application and safety of ICS withdrawal remain controversial. This study aimed to evaluate the association between outcomes in elderly patients with COPD or without comorbid bronchial asthma, who were hospitalised exacerbation. Patients methods We conducted a retrospective cohort using Japanese Diagnosis Procedure Combination database from July 2010 March 2016 . identified...
The optimal postoperative treatment strategy for small cell lung cancer (SCLC) remains unclear, especially in patients with lymph node metastasis. We aimed to compare the outcomes of SCLC and metastasis treated adjuvant chemotherapy or chemoradiotherapy. retrospectively collected data on diagnosed N1 N2 from Diagnosis Procedure Combination database Japan, between July 2010 March 2015. extracted patient age, sex, comorbidities, TNM classification at surgery; operative procedures, drugs,...
<b><i>Background:</i></b> Recent advances in bronchoscopy utilizing endobronchial ultrasound (EBUS) as well lung cancer therapy may have driven physicians to perform diagnostic (DB) for high-risk patients. <b><i>Objectives:</i></b> The aim of this study was clarify the relationship between hospital volume (HV) and outcomes DB. <b><i>Methods:</i></b> We collected data on inpatients with who underwent DB from July 2010...
Abstract Naftopidil, an α‐1 adrenoceptor antagonist with few adverse effects, is prescribed for prostate hyperplasia. Naftopidil inhibits fibroblast proliferation; however, its effects on lung fibroblasts and fibrosis remain largely unknown. Two normal one idiopathic pulmonary human lines were cultured various naftopidil concentrations or without phenoxybenzamine, irreversible inhibitor. We examined the incorporation of 5‐bromo‐2ʹ‐deoxyuridine into DNA lactic acid dehydrogenase release by...
TSLP induces Th2 cytokine production by cells and various other types of cells, thereby contributing to Th2-type immune responses development allergic disorders. We found that house dust mite (HDM) extract induced nasal epithelial suggesting may be involved in HDM-induced rhinitis (AR). To investigate possibility greater detail, wild-type receptor-deficient (TSLPR−/−) mice on the C57BL/6J background were repeatedly treated intranasally with HDM extract. The frequency sneezing, numbers...
Brain metastasis frequently develops in non-small-cell lung cancer (NSCLC). Here, we report a patient who developed brain from ALK-positive NSCLC which mimicked abscess. He was admitted for suspected obstructive pneumonia nine months after curative resection. Head magnetic resonance imaging revealed cavitary lesion, compatible with abscess but rare metastasis. However, treatment antibiotics, the lesion increased size. Aspiration of liquid content cells. When suggestive NSCLC, aspiration may...
T cell immunoglobulin domain and mucin domain-containing molecule 3 (TIM-3), which is preferentially expressed on Th1 cells rather than Th2 cells, considered to be a negative regulator of function. This suggests that TIM-3 indirectly enhances Th2-type immune responses by suppressing function.To investigate TIM-3's possible involvement in acute chronic airway inflammation, wild-type TIM-3-deficient (TIM-3-/-) mice were sensitized challenged with house dust mite (HDM) extract. Airway...
Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) may effectively treat acute pulmonary embolisms (PEs). Here, we assessed the effectiveness of clot dissolution and safety tissue plasminogen activator (t-PA) using EBUS-TBNI in a 1-week survival study porcine PE model.Six pigs with bilateral PEs were used: 3 for t-PA (TBNI group) systemic administration (systemic group). Once created, each 25 mg (a total 50 t-PA) 100 was performed on day 1. Hemodynamic parameters,...