A5040813020- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Blood Pressure and Hypertension Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Respiratory and Cough-Related Research
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Emergency and Acute Care Studies
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Chemotherapy-induced cardiotoxicity and mitigation
- Tuberculosis Research and Epidemiology
- Pharmacological Effects of Natural Compounds
The University of Tokyo
2016-2025
University of Tokyo Health Sciences
2015-2025
University of Tokyo Hospital
2013-2025
Weatherford College
2023
Nihon University
2021
Kitasato University
2021
Pulmonary Associates
2021
University of Indonesia
2021
Juntendo University
2021
Ministry of Health Labour and Welfare
2020
Heart failure (HF) and atrial fibrillation (AF) are growing in prevalence worldwide. Few studies have assessed to what extent stage 1 hypertension the 2017 American College of Cardiology/American Association blood pressure (BP) guidelines is associated with incident HF AF.Analyses were conducted a nationwide health claims database collected JMDC Claims Database between 2005 2018 (n=2 196 437; mean age, 44.0±10.9 years; 58.4% men). No participants taking antihypertensive medication or had...
Data on the association between body mass index (BMI) and stroke are scarce. We aimed to examine BMI incident (ischemic or hemorrhagic) clarify relationship underweight, overweight, obesity risk stratified by sex. analyzed JMDC Claims Database January 2005 April 2020 including 2,740,778 healthy individuals (Median (interquartile) age, 45 (38–53) years; 56.2% men; median BMI, 22.3 (20.2–24.8) kg/m2). None of participants had a history cardiovascular disease. Each participant was categorized...
Abstract Background There have been scarce data comparing cardiovascular outcomes between individual sodium-glucose cotransporter-2 (SGLT2) inhibitors. We aimed to compare the subsequent risk SGLT2 Methods analyzed 25,315 patients with diabetes mellitus (DM) newly taking inhibitors (empagliflozin: 5302, dapagliflozin: 4681, canagliflozin: 4411, other inhibitors: 10,921). compared risks of developing heart failure (HF), myocardial infarction (MI), angina pectoris (AP), stroke, and atrial...
Background There have been limited data examining the age‐dependent relationship of wide‐range risk factors with incidence each subtype cardiovascular disease (CVD) event. We assessed age‐related associations between modifiable and CVD. Methods Results analyzed 3 027 839 participants without a CVD history enrolled in JMDC Claims Database (mean age, 44.8±11.0 years; 57.6% men). Each participant was categorized as aged 20 to 49 years (n=2 008 559), 50 59 (n=712 273), 60 75 (n=307 007). Using...
Depression is a known risk factor for cardiovascular disease (CVD), but the potential sex differences in this association remain unclear. The aim of study was to investigate between depression and subsequent CVD events, explore differences. We conducted retrospective analysis using JMDC Claims Database 2005 2022. population included 4,125,720 individuals aged 18 75 years without history or renal failure missing data at baseline. Participants were followed up mean 1,288 days assess such as...
The prevalence and mortality of chronic obstructive pulmonary disease (COPD) in elderly patients are increasing worldwide. Low body mass index (BMI) is a well-known prognostic factor for COPD. However, the obesity paradox with COPD has not been well elucidated. We investigated association between BMI in-hospital patients.Using Diagnosis Procedure Combination database Japan, we retrospectively collected data (>65 years) who were hospitalized July 2010 March 2013. performed multivariable...
Background The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines lowered the threshold blood pressure (BP) for hypertension to 130/80 mm Hg. However, clinical significance isolated diastolic (IDH) according cutoff value ACC/AHA was uncertain. Methods and Results We analyzed claims database Japan Medical Data Center (a nationwide epidemiological database). excluded individuals who were aged <20 years, had systolic hypertension, taking antihypertensive...
Abstract Background Direct comparative effectiveness of booster doses BNT162b2 and mRNA-1273 after primary vaccination is unknown. Methods We investigated dose using data from registry systems for coronavirus disease 2019 (COVID-19) infection in a local city Japan. followed participants aged ≥16 years who completed the between 22 November 2021, 15 April 2022. collected information on age, sex, status, vaccine type, status. Age was categorized as 16–44, 45–64, 65–84, ≥85 years. Vaccine no...
Abstract Aims HDL cholesterol (HDL-C) has been thought to protect against cardiovascular disease (CVD), whereas a U-shaped association of both low and extremely high HDL-C with mortality risk increasingly reported in recent years. However, whether this is universal regardless the individual’s clinical background, including lifestyle diseases, remains unclear. We examined fasting plasma glucose modifies between level outcomes. Methods results This retrospective observational cohort study...
The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome an established factor for CVD, its association with survivors has not yet been established. This study aimed to clarify whether associated CVD patients using a nationwide epidemiological dataset.
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide. Patients with COPD frequently have systemic comorbidities that often require unscheduled hospitalization for exacerbation and deterioration physical conditions, can poor prognosis. We verified factors affecting patients' short-term mortality, using national inpatient database in Japan.We retrospectively collected data patients (age: >40 years) emergency admission between July 2010 March 2013, the Diagnosis...
Obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), have airflow limitation associated with inflammation. Using a national inpatient database in Japan, we aimed to evaluate factors affecting in-hospital mortality patients asthma, COPD or asthma-COPD overlap (ACO).We retrospectively collected data for inpatients (age >40 years) exacerbation of and/or 1073 hospitals across Japan between July 2010 May 2013. We performed multivariable logistic regression...
Cancer survivors have a greater risk of cardiovascular disease (CVD). Although Life's Simple 7 is used for CVD stratification in general population, its utility cancer remains unknown. We aimed to clarify the association with incident among survivors. Furthermore, we analyzed relationship between change and subsequent risk. This retrospective observational study was conducted using JMDC Claims Database, 53 974 patients prior history breast, colorectal, or stomach cancer, which common site...
Despite the growing recognition of importance hypertension in patients with cancer, little is known about whether high blood pressure (BP) among cancer associated incident heart failure (HF) and other cardiovascular disease (CVD) events what BP levels are linked to these events. We examined association classification on basis 2017 American College Cardiology/American Heart Association guideline risk HF CVD cancer.We studied 33,991 a history breast, colorectal, or stomach (median age, 53...
There are few data on sex differences in the association between schizophrenia and development of cardiovascular disease (CVD). We sought to clarify relationship with risk developing CVDs explore potential modification effect differences.
Abstract Background and Objective Pyrazinamide (PZA) is the standard first‐line treatment for tuberculosis (TB); however, its safety in elderly patients has not been thoroughly investigated. Methods This retrospective study used data from Japanese Diagnosis Procedure Combination inpatient database. We identified who were admitted TB between July 2010 March 2022. Patients categorized into HRE (isoniazid, rifampicin ethambutol) HREZ rifampicin, ethambutol PZA) groups. Primary outcomes included...
While machine learning approaches can enhance prediction ability, little is known about their ability to predict 30-day readmission after hospitalization for Chronic Obstructive Pulmonary Disease (COPD). We identified patients aged ≥40 years with unplanned due COPD in the Diagnosis Procedure Combination database, an administrative claims database Japan, from 2011 through 2016 (index hospitalizations). was defined by ICD-10-CM diagnostic codes, according Centers Medicare and Medicaid Services...