A5081099541- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Interprofessional Education and Collaboration
- Acute Myocardial Infarction Research
- Metabolism, Diabetes, and Cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- TGF-β signaling in diseases
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Fatty Acid Research and Health
- Complex Systems and Time Series Analysis
- Regulation of Appetite and Obesity
- Cancer-related gene regulation
- Advanced Text Analysis Techniques
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic function and diabetes
- Innovations in Medical Education
- Parathyroid Disorders and Treatments
University of Tokyo Health Sciences
2017-2025
Kameda Medical Center
2017-2025
The University of Tokyo
2021-2025
Ritsumeikan University
2025
University of Tokyo Hospital
2025
Jichi Medical University
2025
Gunma University
2015-2024
Tokyo Medical and Dental University
2019
Dokkyo Medical University
2019
Social Insurance Saitama Chuo Hospital
2019
Objective— Fatty acids (FAs) are the major substrate for energy production in heart. Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role providing sufficient FAs to myocardium. Approach Results— Both FABP4/5 were abundantly expressed endothelium heart skeletal muscle. The uptake of a FA analogue, 125I-15-( p -iodophenyl)-3-(R,S)-methyl pentadecanoic acid, was significantly reduced these tissues double-knockout (DKO) mice...
Hypoxia-inducible factor-1α (HIF-1α), a transcription factor that functions as master regulator of oxygen homeostasis, has been implicated in fibrinogenesis. Here, we explore the role HIF-1α transforming growth factor-β (TGF-β) signaling by examining effects TGF-β(1) on expression plasminogen activator inhibitor-1 (PAI-1). Immunohistochemistry lung tissue from mouse bleomycin (BLM)-induced pulmonary fibrosis model revealed and PAI-1 was predominantly induced alveolar macrophages. Real-time...
Notch is an ancient cell-signaling system that regulates the specification of cell fate. This study examined role in epithelial-mesenchymal transition (EMT) and myofibroblast differentiation cultured RLE-6TN cells (i.e., rat alveolar epithelial cells). The activation Notch, either by ectopic expression intracellular domain or co-culture with L-Jagged1 cells, induces smooth muscle α-actin (SMA) other mesenchymal marker genes (collagen I vimentin), reduces (E-cadherin, occludin, zonula...
Mismatch between the uptake and utilization of long-chain fatty acids in myocardium leads to abnormally high intracellular acid concentration, which ultimately induces myocardial dysfunction. Stearoyl-Coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that converts saturated (SFAs) monounsaturated acids. Previous studies have shown SCD1-deficinent mice are protected from insulin resistance diet-induced obesity; however, role SCD1 heart remains be determined. We examined expression...
Obstructive sleep apnea syndrome (OSAS) is frequently complicated by metabolic syndrome, including diabetes and hypertension. Both OSAS are strongly associated with obesity. Recently, adiponectin leptin, which secreted adipose tissue, have been considered to play important roles in the progression of these diseases. Thus, examine association between OSAS, we measured serum level adipocytokines same patients.Sixty-eight consecutive Japanese men, who recorded all-night polysomnography, were...
Vascular calcification is regulated in a process similar to bone formation. BMP2 (bone morphogenetic protein 2) essential for osteoblastic differentiation of mesenchymal progenitor cells and thus has been implicated the development vascular calcification. Here we examined whether Notch signaling interacts with regulate osteogenic mineralization smooth muscle (SMCs). alone scarcely induced expression alkaline phosphatase (ALP), an ectoenzyme crucially required active biomineralization, human...
Background Endothelium is a crucial blood–tissue interface controlling energy supply according to organ needs. We investigated whether peroxisome proliferator‐activated receptor‐γ ( PPAR γ) induces expression of fatty acid–binding protein 4 FABP 4) and acid translocase FAT )/ CD 36 in capillary endothelial cells EC s) promote FA transport into the heart. Methods Results Expression was induced by γ agonist pioglitazone human cardiac microvessel s HCMEC s), but not umbilical vein s. Real‐time...
Free fatty acids (FFAs), elevated in metabolic syndrome and diabetes, play a crucial role the development of atherosclerotic cardiovascular disease, eicosapentaenoic acid (EPA) counteracts many aspects FFA-induced vascular pathology. Although calcification is invariably associated with atherosclerosis, mechanisms involved are not completely elucidated. In this study, we tested hypothesis that EPA prevents osteoblastic differentiation mineralization smooth muscle cells (VSMC) induced by...
The goal of effective interprofessional education (IPE) is high-quality patient-care delivery and attaining a high level patient satisfaction in clinical settings. We aimed to examine if alumni who have studied an IPE program at pre-licensure stage maintain positive attitude toward collaborative practice (CP) the postgraduate experience. This paper presents cross-sectional descriptive study which employed modified attitudes health care teams scale (ATHCTS) relationship between exposure...
Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI 43 stable angina pectoris (sAP) for FGF21, fatty acid binding protein 4 (FABP4), secreted adipocytes in response to adrenergic lipolytic signal, total individual acids. Compared sAP patients, had higher serum levels on admission,...
The metabolism of the failing heart is characterized by an increase in glucose uptake with reduced fatty acid (FA) oxidation. We previously found that genetic deletion FA-binding protein-4 and -5 [double knockout (DKO)] induces increased myocardial reliance on decreased FA mice. However, whether this fuel switch confers functional benefit during hypertrophic response remains open to debate. To address question, we investigated contractile function metabolic profile DKO hearts subjected...
Phenotypic plasticity and the switching of vascular smooth muscle cells (SMCs) play a critical role in atherosclerosis. Although Runx2, key osteogenic transcription factor, is expressed atherosclerotic plaques, molecular mechanisms by which Runx2 regulates SMC differentiation remain unclear. Here we demonstrated that repressed induced myocardin, acts as coactivator for serum response factor (SRF). Myocardin-mediated induction gene expression was enhanced mouse embryonic fibroblasts derived...
During prolonged fasting, fatty acid (FA) released from adipose tissue is a major energy source for peripheral tissues, including the heart, skeletal muscle and liver. We recently showed that FA binding protein 4 (FABP4) FABP5, which are abundantly expressed in adipocytes macrophages, prominently capillary endothelial cells heart muscle. In addition, mice deficient both FABP4 FABP5 (FABP4/5 DKO mice) exhibited defective uptake of with compensatory up-regulation glucose consumption these...
Hypothermia is rapidly induced during cold exposure when thermoregulatory mechanisms, including fatty acid (FA) utilization, are disturbed. FA binding protein 4 (FABP4) and FABP5, which abundantly expressed in adipose tissues macrophages, have been identified as key molecules the pathogenesis of overnutrition-related diseases, such insulin resistance atherosclerosis. We recently shown that FABP4/5 prominently capillary endothelial cells heart skeletal muscle play a crucial role utilization...
Background Fatty acids constitute the critical components of cell structure and function, dysregulation fatty acid composition may exert diverging vascular effects including proliferation, migration, differentiation smooth muscle cells ( VSMC s). However, direct evidence for this hypothesis has been lacking. We investigated role elongation long‐chain member 6 (Elovl6), a rate‐limiting enzyme catalyzing saturated monounsaturated acid, in regulation phenotypic switching . Methods Results...
The energy metabolism of the failing heart is characterized by reduced fatty acid (FA) oxidation and an increase in glucose utilization. However, little known about how metabolism-function relationship relevant to pathophysiology failure. Recent study showed that genetic deletion CD36 (CD36KO), which causes reduction FA use with increased reliance on glucose, accelerates progression from compensated hypertrophy Here, we show mechanisms failure response pressure overload. CD36KO mice...
Abstract Background and Objective Pyrazinamide (PZA) is the standard first‐line treatment for tuberculosis (TB); however, its safety in elderly patients has not been thoroughly investigated. Methods This retrospective study used data from Japanese Diagnosis Procedure Combination inpatient database. We identified who were admitted TB between July 2010 March 2022. Patients categorized into HRE (isoniazid, rifampicin ethambutol) HREZ rifampicin, ethambutol PZA) groups. Primary outcomes included...
The relationship between blood lipid profile and coronary plaque tissue characteristics, differences in the characteristics acute syndrome (ACS) chronic artery disease (CCAD) are unclear. purpose of present study was to compare patients with ACS CCAD examine profile.Integrated backscatter intravascular ultrasound (IVUS) conventional IVUS were performed (n=24) (n=68) at time intervention. Percent volume cross-section area pool, fibrous tissue, dense calcification defined target lesions. pool...
Objective— TGFβ and proliferation/phenotypic switching of smooth muscle cells (SMCs) play a pivotal role in pathogenesis atherosclerotic restenotic lesions after angioplasty. We have previously shown that the protein inhibitor activated STAT (PIAS)1 activates expression SMC differentiation marker genes including (SM) α-actin by interacting with serum response factor (SRF) class I bHLH proteins. Here, we tested hypothesis SM through PIAS1. Methods Results— An siRNA specific for PIAS1 ubc9, an...
Abstract Background A reduction in mortality with the early use of tranexamic acid has been demonstrated severely injured patients who are bleeding. However, modest treatment effect no blood transfusion raised concerns. The aim present study was to estimate effectiveness regular patients. Methods This multicentre observational used retrospectively collected data from consecutive (Injury Severity Score at least 16) treated 15 Japanese academic institutions 2012. propensity score-matched...
Communication underpinning well-functioning teamwork is a key mechanism for patient safety. Undergraduate interprofessional education (IPE) provides students with basic understanding of the psychological factors contributing to teamwork. To develop IPE fostering collaborative mindset safety, attitudinal changes safety were evaluated. Changes in scores modified attitudes toward health care teams scale (ATHCTS) and questionnaire (T-TAQ) pre- post-IPE program evaluated 2017 academic year. One...