A5069646629- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Enterobacteriaceae and Cronobacter Research
- Amoebic Infections and Treatments
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- Dermatological and COVID-19 studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
Toho University
2011-2025
Japanese Foundation For Cancer Research
2014-2025
University of Tokyo Hospital
2008-2024
The University of Tokyo
1987-2022
Fujita Health University
2018-2021
Kawasaki Municipal Hospital
2021
Fujita Health University Hospital
2019
Toho University Omori Medical Center
2013
Tokyo Teishin Hospital
2011
National Institute of Infectious Diseases
2008
Although hypervirulent Klebsiella pneumoniae (hvKp) has been associated with severe community-acquired infections that occur among relatively healthy individuals, information about hvKp in health care settings remains limited. Here, we systematically analyzed the clinical and molecular characteristics of K. isolates causing bloodstream a cross-sectional study. Clinical from hospitals across Japan were by review medical records. Whole-genome sequencing causative was performed. Bacterial...
Hypervirulent Klebsiella pneumoniae strains have higher potential to cause more severe and disseminated infections than classic K. strains. While initially reported from East Asian countries, cases now been identified worldwide, sometimes in conjunction with extensive drug resistance. In this issue of the Journal Clinical Microbiology, T. A. Russo et al. (J Clin Microbiol 56:e00776-18, 2018, https://doi.org/10.1128/JCM.00776-18) validated diagnostic accuracy biomarkers that differentiate...
ABSTRACT Although KPC enzymes are most common among carbapenemases produced by Enterobacter cloacae complex globally, the epidemiology varies from one country to another. While previous studies have suggested that IMP in Japan, detailed analysis has been scarce thus far. Here, we carried out a molecular epidemiological study and plasmid of IMP-1-producing E. isolates collected three hospitals central Tokyo using whole-genome sequencing. Seventy-one were classified into several sequence types...
Abstract A patient in Japan with coronavirus disease and hypervirulent Klebsiella pneumoniae K2 sequence type 86 infection died of respiratory failure. Bacterial fungal co-infections caused by region-endemic pathogens, including K. eastern Asia, should be included the differential diagnosis patients acutely deteriorating condition.
Urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are on the increase. Although cefmetazole is stable in vitro against hydrolyzing activity of ESBLs, no clinical study has ever evaluated its role these organisms. We therefore efficacy compared to carbapenems pyelonephritis ESBL-producing Enterobacteriaceae.A retrospective chart review was conducted at a tertiary care hospital from August 2008 July 2010. Chart reviews were done for...
Abstract Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID‐19). Therefore, investigating biomarkers associated with severity important for understanding the mechanisms responsible this heterogeneity and developing novel agents to prevent critical conditions. This study aimed elucidate modulations sphingolipids glycerophospholipids, which have been shown possess potent biological properties. Methods We measured serum sphingolipid...
To evaluate the efficacy and safety of nafamostat combined with favipiravir for treatment COVID-19.We conducted a multicenter, randomized, single-blind, placebo-controlled, parallel assignment study in hospitalized patients mild-to-moderate COVID-19 pneumonia. Patients were randomly assigned to receive alone (n = 24) or 21). The outcomes included changes World Health Organization clinical progression scale score, time improvement body temperature, oxygen saturation (SpO2).There was no...
Integrating conjugative elements (ICEs) are mobile genetic that can transfer from the chromosome of a host to new through process excision, conjugation, and integration. Although SXT/R391-related ICEs, originally demonstrated in Vibrio cholerae O139 isolates, have become prevalent among V. isolates Asia, prevalence ICEs gram-negative bacteria other than spp. remains unknown. In addition, carrying genes conferring resistance extended-spectrum cephalosporins never been described. Here we...
ABSTRACT Capsule-forming Klebsiella pneumoniae K1 caused primary liver abscess in two household members of a family. The causative isolates had identical pulsed-field gel electrophoresis patterns and were determined to be sequence type 23. An additional member the family was found carry same strain without clinical manifestation.
Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are related to the mortality COVID-19.In this retrospective cross-sectional study, we measured sphingolipids and glycerophospholipids, which have been shown possess potent biological properties, using liquid chromatography-mass spectrometry in 272 urine samples collected longitudinally from 91 COVID-19...
Abstract Several clinical trials have shown that the humoral response produced by anti-spike antibodies elicited coronavirus disease 2019 (COVID-19) vaccines gradually declines. The kinetics, durability and influence of epidemiological factors on cellular immunity not been fully elucidated. We analyzed immune responses BNT162b2 mRNA in 321 health care workers using whole blood interferon-gamma (IFN-γ) release assays. IFN-γ, induced CD4 + CD8 T cells stimulated with severe acute respiratory...
Background: Effective infection prevention and control (IPC) interventions in hospitals require timely information to determine the potential transmission of antimicrobial-resistant (AMR) organisms. Objectives: We validated a successive core-genome single nucleotide polymorphism (cgSNP)-based phylogenetic analysis workflow, ′Tracking Antimicrobial Resistant Organisms Timely′ (TAROT), with Oxford Nanopore Technologies (ONT) sequencer for methicillin-resistant Staphylococcus aureus (MRSA)....
Abstract Background Corynebacterium spp. is increasingly identified due to widespread use of MALDI-TOF MS in clinical laboratories. However, accuracy identification and genetic characteristics isolates are unclear. Methods We collected 17 from cases diagnosed as infections caused by at a single center Japan. Species was performed using MALDI Biotyper with reference library BDAL v11 (Bruker). Whole-genome sequencing (WGS) also MiSeq (Illumina), the species were genetically threshold ≥ 95%...
Abstract Background Klebsiella pneumoniae (KP) infections are common in the Philippines. Local carbapenem resistance (CR) is at 11-50%. In addition to rising antimicrobial (AMR), some types of KP cause disseminated infection that can lead poor clinical outcomes. Aside from describing AMR, it also important identify virulence genes fully understand pathogenesis infections. There no local data on characterization isolates and its impact patient Methods This a cross-sectional study utilized...
Abstract Background Clinical studies on clostridial bacteremia are scarce, and the factors associated with mortality have not been well investigated. Furthermore, distribution of Clostridium species varied among studies. To investigate epidemiology mortality, we conducted a study in Japan. Methods This multicenter, retrospective, observational was four Japanese hospitals. Patients whom spp. were detected blood cultures between 2007 2021 included. Only first episode infection included culture...
ABSTRACT The genus Aeromonas is increasingly implicated in human infections. However, accurate species-level identification remains challenging, particularly clinical microbiology laboratories. This study aimed to develop a multiplex polymerase chain reaction (PCR) assay identify four species— hydrophila , caviae veronii and dhakensis— most frequently associated with infectious diseases. A total of 788 whole genome sequencing (WGS) data sets from 31 species were analyzed open reading frames...
ABSTRACT Klebsiella variicola is an emerging pathogen within the pneumoniae species complex, and its clinical microbiological characteristics remain poorly understood. This retrospective case-control study analyzed 252 patients with bloodstream infections caused by K. including 60 infection, to elucidate these characteristics. Our showed no significant differences in outcomes, such as 30-day mortality, between . However, a difference was found rate of harboring [ peg-344 , iucA rmpA ] genes,...
Non-tuberculous mycobacteria infections, including Mycobacterium avium, are increasingly recognized as a growing public health concern, even among immunocompetent individuals. These infections significant cause of chronic pulmonary disease, and they characterized by the formation foamy macrophages (FMs) that facilitate bacterial persistence. Previously, we reported apoptosis inhibitor macrophage (AIM), protein secreted macrophages, promotes lipid droplet accumulation in M. avium-infected...